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Article
Erythema nodosum and giardia intestinalis
We present the first report of erythema nodosum occurring in a woman with an intestinal infection due to giardia lamblia, an association not previously described. The authors suggest the possible role of giard...
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Bf polymorphism and juvenile rheumatoid arthritis
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Evaluation of the renal injury from gold salts and nonsteroidal anti-inflammatory drugs in patients with rheumatoid arthritis
The urinary excretion of proteins, N-acetil-3-glucosaminidase and leucine aminopeptidase, was measured in 50 patients with rheumatoid arthritis (RA), of whom 20 subjects were on nonsteroidal anti-inflammatory ...
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Article
Peptide opioids and morphine effects on inflammatory process
Morphine was found to inhibit human granulocyte aggregation and ATP, thromboxane B2 (TxB2), and leukotriene B4 (LTB4) secretion during cell aggregation. None of the opioid peptides tested [(d-Ala2,d-Leu5)-enkepha...
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Article
Systemic sclerosis following anti-androgenic treatment for prostatic adenocarcinoma
We describe a male patient who developed systemic sclerosis following orchiectomy, radiotherapy and anti-androgenic treatment for prostatic adenocarcinoma. This case appears interesting as it further supports ...
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Article
Involvement of atlanto-axial joint in rheumatoid arthritis: Rare or frequent?
The authors studied the incidence of atlanto-axial joint involvement by conventional radiography and CT in 183 patients with classical or definite rheumatoid arthritis (RA). In determining lesions the signific...
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Article
Lymphoedema of the limbs in rheumatoid arthritis
The lymphoedema of the extremities is a rare complication of rheumatoid arthritis (RA); it does not appear to be correlated with positivity for rheumatoid factor nor with the clinical activity of the disease. ...
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Article
Hladistribution in Italian patients with fibromyalgia
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Preface
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Article
HLA-B27 positive ankylosing spondylitis and polyarteritis nodosa: a case report
A35-year-old man, with positive HBV and HCV markers, showed clinical and histopathological features of polyarteritis nodosa (PAN), in the course of HLA-B27 positive ankylosing spondylitis (AS). The possible oc...
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Article
Small Acoustic Neuromas: Monitoring the Growth Rate by MRI
In a proportion of small acoustic neuroma patients, monitoring with magnetic resonance imaging shows no volumetric increase of tumour size over the years. The object of the study was to identify some indicati...
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Article
Capillaroscopic Findings in Erosive and Nodal Osteoarthritis of the Hands
Osteoarthritis of the hands is a very common disease that can present a large number of different clinic pictures, such as nodal (NOA) and erosive (EOA) forms. EOA in particular is a rare subset of hand osteo...
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Article
Structure and mechanical properties of low stress tetrahedral amorphous carbon films prepared by pulsed laser deposition
Tetrahedral amorphous carbon films have been produced by pulsed laser deposition, at a wavelength of 248 nm, ablating highly oriented pyrolytic graphite at room temperature, in a 10-2 Pa vacuum, at fluences rangi...
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Article
Bobble-head doll syndrome due to a suprasellar arachnoid cyst: endoscopic treatment in two cases
We report two cases of bobble-head doll syndrome associated with a large suprasellar arachnoid cyst successfully treated with a minimally invasive endoscopic approach.
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Article
Open AccessFluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells
The new combination between the nucleoside analogue gemcitabine and the cholesterol-lowering drug fluvastatin was investigated in vitro and in vivo on the human pancreatic tumour cell line MIAPaCa-2. The present ...
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Article
Open AccessA pharmacokinetic and pharmacodynamic study on metronomic irinotecan in metastatic colorectal cancer patients
The pharmacokinetics (PK) and pharmacodynamics (PD) of metronomic irinotecan have not been studied in cancer patients. The aim of the study is to investigate the PK/PD profile of irinotecan/SN-38 administered ...
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Open AccessAntiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib
Metronomic chemotherapy refers to the administration of chemotherapy at low, nontoxic doses on a frequent schedule with no prolonged breaks. The aim of the study is to rationally develop a CPT-11 metronomic re...
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Open AccessAurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer
AZD1152, the prodrug for AZD1152-hydroxyquinazoline pyrazol anilide (HQPA), is a selective inhibitor of Aurora B kinase activity. Preclinical evaluation of AZD1152 has been reported in several human cancer mod...
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Article
Open AccessPharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancer
The identification of molecular and genetic markers to predict or monitor the efficacy of bevacizumab (BV) represents a key issue in the treatment of metastatic colorectal cancer (mCRC).
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Open AccessSerum amyloid A circulating levels and disease activity in patients with juvenile idiopathic arthritis