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Article
Open AccessIncidence, course, and outcome of Clostridium difficile infection in children with hematological malignancies or undergoing hematopoietic stem cell transplantation
Clostridium difficile infection (CDI) is one of the most common causes of nosocomial infectious diarrhea in children during anticancer therapy or undergoing hematopoietic stem cell transplantation (HSCT) in Europ...
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Article
More chronic GvHD and non-relapse mortality after peripheral blood stem cell compared with bone marrow in hematopoietic transplantation for paediatric acute lymphoblastic leukemia: a retrospective study on behalf of the EBMT Paediatric Diseases Working Party
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Chapter
First-Line Immunosuppressive Treatment in Children with Aplastic Anemia: Rabbit Antithymocyte Globulin
Immunosuppressive therapy is the treatment of choice in children with acquired severe aplastic anemia (AA) and no HLA-matched family donor. The paper presents results of a multicenter study of 63 children with...
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Article
Adoptive therapy with donor lymphocyte infusion after allogenic hematopoietic SCT in pediatric patients
The aim of this study was to analyse the experience of Polish Pediatric Group for Hematopoietic Stem Cell Transplantation in respect to donor lymphocyte infusion procedure. The study included 51 pediatric pati...
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Article
Consolidation of first-line therapy with busulphan and melphalan, and autologous stem cell rescue in children with Ewing’s sarcoma
According to the published report on current practice of hematopoietic SCT in Europe, high-dose therapy (HDT) with autologous stem cell support is a standard of care in paediatric patients with high risk (HR) ...
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Article
Treosulfan-based preparative regimens for allo-HSCT in childhood hematological malignancies: a retrospective study on behalf of the EBMT pediatric diseases working party
This retrospective analysis evaluated 51 children (0.7–17 years; median eight) with high-risk or advanced hematological malignancies, including 18 (35%) patients undergoing second/third hematopoietic SCT (allo...
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Article
Long-term results in children with standard risk acute lymphoblastic leukaemia treated with 5.0 g/m2 versus 3.0 g/m2 methotrexate i.v. according to the modified ALL-BFM 90 protocol. The report of Polish paediatric Leukemia/lymphoma study group
PURPOSE: A non objective randomised, retrospective study was performed to assess and compare the efficacy of two different high doses of methotrexate (HD-MTX) in combination with intrathecal therapy in childre...
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Article
Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in children: results of the EWOG-MDS 98 study
We report on the outcome of children with advanced primary myelodysplastic syndrome (MDS) transplanted from an HLA-matched sibling (MSD) or an unrelated donor (UD) following a preparative regimen with busulfan...
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Article
Quality of life and ethical and legal dilemmas in children during and after hematopoietic SCT procedure
There is not any doubt that the SCT procedure involves important ethical and legal aspects. The expectations of patients concerning the quality of life and the new way of treatment are certainly an important m...
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Article
Haematopoietic stem cell transplantation in children in eastern European countries 1985–2004: development, recent activity and role of the EBMT/ESH Outreach Programme
The paediatric population of 19 eastern European countries amounts to approximately 80 million children. Between 1985 and 2004, the number of centres performing haematopoietic stem cell transplantation (HSCT) ...
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Article
Twenty years of Polish experience with three consecutive protocols for treatment of childhood acute myelogenous leukemia
Until 1983, results of treatment of acute myelogenous leukemia (AML) in Poland with different regimens were very poor. In 1983, the Polish Pediatric Leukemia/Lymphoma Study Group introduced a unified treatment...
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Article
Prompt initiation of immunotherapy in children with an increasing number of autologous cells after allogeneic HCT can induce complete donor-type chimerism: a report of 14 children
Immunotherapy consisting of withdrawal of immunosuppression and/or donor lymphocyte infusions was initiated in 14 children (10 acute lymphoblastic leukemia, three acute myeloblastic leukemia and one myelodyspl...
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Chapter and Conference Paper
Results of Stem Cell Transplantation in Children with CML in Comparison with Treatment with Cytostatics alone or with Interferon alfa. Report of the Polish Children’s Leukemia/ Lymphoma Study Group
Philadelphia positive chronic myeloid leukemia (CML Ph+) is a malignant clonal hematological disease of pluripotent stem cell representing 2–5% of all childhood leukemias [2]. The incidence of CML increases with ...
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Chapter and Conference Paper
The Role of Apoptosis in the Course of Acute Leukemia in Children
Apoptosis is the process of programmed cell death. Its disturbances are important part of cancer development. This study aimed at examining clinical and prognostic significance of spontaneous apoptosis level i...
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Chapter
Erythropoietin Use in Therapy of Anemia Associated with Bone Marrow Transplantation in Children
Erythropoietin (EPO) is a hematopoietic growth factor that plays a vital role in erythropoiesis regulating the red blood cell synthesis. EPO is a hormone-like glycoprotein (molecular weight 24 000 daltons) tha...
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Chapter and Conference Paper
ICAM-1 Levels Correlations with Cytokine (IL-1, IL-6 and TNF) Production During the Course of Acute Lymphoblastic Leukemia (ALL) in Children
This study was undertaken to establish the role of ICAM -1 levels and their correlation with cytokines (IL-1, IL-6 and TNF) production in the pathogenesis and in the clinical course of childhood ALL. A total n...
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Chapter and Conference Paper
Experience with BFM 1990 Protocol Treatment of Recurrent Childhood Lymphoblastic Leukemia. Report of the Polish Children’s Leukemia/Lymphoma Study Group
Between 1993 and 1996,54 children aged from 6 mths-18 years (16 girls and 38 boys) with first relapse of acute lymphoblastic leukemia were included to the study. The children were treated according to the BFM ...
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Chapter and Conference Paper
Interleukins (IL-1, IL-2, IL-4, IL6) and TNF Production in Children with Acute Lymphoblastic Leukemia
This study was undertaken to establish the role of cytokines (IL-1, IL-2, IL-4, IL-6, and TNF) in the pathogenesis and the clinical course of childhood ALL. A total of 150 children with ALL (88 boys and 62 gir...
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Chapter and Conference Paper
The Experience of Polish Children’s Leukemia Lymphoma Study Group on G-CSF and GM-CSF Interventional Use in Neutropenia Associated with Chemotherapy of Childhood Acute Lymphoblastic Leukemia (ALL)
The aim of this study was to determine a clinical efficacy and tolerance of G and GM-CSF in children with neutropenia and infectious complications, associated with chemotherapy of ALL. Total number of 38 cours...
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Chapter and Conference Paper
Six Years’ Experience with Treatment of Recurrent Childhood Lymphoblastic Leukemia. Report of the Polish Children’s Leukemia/Lymphoma Study Group
Between June 1987 and April 1993, 147 children aged from 2–18 years (47 girls and 100 boys) with first relapse of acute lymphoblastic leukemia were included to the study. The children were treated according to...
