83 Result(s)

Article

Next-generation sequencing indicates false-positive MRD results and better predicts prognosis after SCT in patients with childhood ALL

Minimal residual disease (MRD) monitoring via quantitative PCR (qPCR) detection of Ag receptor gene rearrangements has been the most sensitive method for predicting prognosis and making post-transplant treatme...

M Kotrova, V H J van der Velden, J J M van Dongen… in Bone Marrow Transplantation (2017)

Article

Outcome of relapsed infant acute lymphoblastic leukemia treated on the interfant-99 protocol

E M C Driessen, P de Lorenzo, M Campbell, M Felice, A Ferster, I Hann, A Vora… in Leukemia (2016)

Article

miR-139-5p controls translation in myeloid leukemia through EIF4G2

MicroRNAs (miRNAs) are crucial components of homeostatic and developmental gene regulation. In turn, dysregulation of miRNA expression is a common feature of different types of cancer, which can be harnessed t...

S Emmrich, F Engeland, M El-Khatib, K Henke, A Obulkasim, J Schöning… in Oncogene (2016)

Article

Additional treatment with 2-Chloro-2-Deoxyadenosine during consolidation in children with high-risk acute myeloid leukemia does not improve survival

U Creutzig, M N Dworzak, M Zimmermann, J-P Bourquin, B Gruhn, G Fleischhack… in Leukemia (2015)

Article

Unique BHLHB3 overexpression in pediatric acute myeloid leukemia with t(6;11)(q27;q23)

E A Coenen, C M Zwaan, J Stary, A Baruchel, V de Haas, R W Stam, D Reinhardt… in Leukemia (2014)

Article

miR-9 is a tumor suppressor in pediatric AML with t(8;21)

MicroRNAs (miRNAs) play a pivotal role in the regulation of hematopoiesis and development of leukemia. Great interest emerged in modulating miRNA expression for therapeutic purposes. In order to identify miRNA...

S Emmrich, J E Katsman-Kuipers, K Henke, M E Khatib, R Jammal, F Engeland… in Leukemia (2014)

Article

CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage

Switches from the lymphoid to myeloid lineage during B-cell precursor acute lymphoblastic leukemia (BCP-ALL) treatment are considered rare and thus far have been detected in MLL-rearranged leukemia. Here, we d...

L Slamova, J Starkova, E Fronkova, M Zaliova, L Reznickova, F W van Delft… in Leukemia (2014)

Article

The clinical relevance of minor paroxysmal nocturnal hemoglobinuria clones in refractory cytopenia of childhood: a prospective study by EWOG-MDS

A M Aalbers, V H J van der Velden, A Yoshimi, A Fischer, P Noellke, C M Zwaan… in Leukemia (2014)

Article

Applicability of a reproducible flow cytometry scoring system in the diagnosis of refractory cytopenia of childhood

A M Aalbers, M M van den Heuvel-Eibrink, V de Haas, J G te Marvelde… in Leukemia (2013)

Article

Evaluation of WT1 expression in bone marrow vs peripheral blood samples of children with acute myeloid leukemia—impact on minimal residual disease detection

K Kramarzova, L Boublikova, J Stary, J Trka in Leukemia (2013)

Article

The clinical relevance of BAALC and ERG expression levels in pediatric AML

M C H Hermkens, M M van den Heuvel-Eibrink, S T C J M Arentsen-Peters… in Leukemia (2013)

Chapter and Conference Paper

Parallel Solvers for Numerical Upscaling

This contribution deals with numerical upscaling of the elastic material behaviour, namely of geocomposites, from microscale to macroscale through finite element analysis. This computationally demanding task r...

R. Blaheta, O. Jakl, J. Starý, Erhan Turan in Applied Parallel and Scientific Computing (2013)

Article

Real-time PCR quantification of major Wilms’ tumor gene 1 (WT1) isoforms in acute myeloid leukemia, their characteristic expression patterns and possible functional consequences

Wilms’ tumor gene 1 (WT1) functions including some contradictory effects may be explained by the presence and interactions of its isoforms, however, their evaluation has been so far complicated by several technic...

K Kramarzova, J Stuchly, A Willasch, B Gruhn, J Schwarz, J Cermak… in Leukemia (2012)

Article

Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report

Infants <1 year of age have a high prevalence of prognostically unfavorable leukemias and a presumed susceptibility to treatment-related toxicities. A total of 125 infants with acute myeloid leukemia (AML) wer...

U Creutzig, M Zimmermann, J-P Bourquin, M N Dworzak, B Kremens, T Lehrnbecher… in Leukemia (2012)

Article

History of treatment and long-term outcome in children with acute lymphoblastic leukemia in the Czech Republic

PURPOSE: Treatment of childhood acute lymphoblastic leukemia (ALL) was unified in the year 1986 in the Czech Republic using BFM protocols. PATIENTS AND METHODS: Children were treated in 10 and later on in 8 ce...

J. Starý, V. Mihál, P. Smíšek, B. Blažek… in memo - Magazine of European Medical Oncolo… (2011)

Article

Signature profiles of CMV-specific T-cells in patients with CMV reactivation after hematopoietic SCT

Depletion of cellular immunity as a consequence of conditioning before allogeneic hematopoietic SCT (HSCT) frequently results in CMV reactivation, which may in turn lead to life-threatening infections and requ...

L Król, J Stuchlý, P Hubáček, P Keslová, P Sedláček, J Starý… in Bone Marrow Transplantation (2011)

Article

Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in children: results of the EWOG-MDS 98 study

We report on the outcome of children with advanced primary myelodysplastic syndrome (MDS) transplanted from an HLA-matched sibling (MSD) or an unrelated donor (UD) following a preparative regimen with busulfan...

B Strahm, P Nöllke, M Zecca, E T Korthof, M Bierings, I Furlan, P Sedlacek… in Leukemia (2011)