-
Article
Comparing neoadjuvant therapy followed by local excision to total mesorectal excision in the treatment of early stage rectal cancer: a systematic review and meta-analysis of randomised clinical trials
Total mesorectal excision (TME) is the standard-of-care in early, clinical stage (cT2-3 N0 M0) rectal cancer. Local excision (LE) may be an alternative after adequate response to neoadjuvant therapy (NAT), wit...
-
Article
Open AccessThe Impact of Bariatric Surgery on the Incidence of Colorectal Cancer in Patients with Obesity—a Systematic Review and Meta-analysis of Registry Data
Cancer and obesity represent two of the most significant global health concerns. The risk of malignancy, including colorectal cancer (CRC), increases with obesity. The aim of this study was to perform a system...
-
Article
Open AccessComparing surgical outcomes of approaches to adrenalectomy — a systematic review and network meta-analysis of randomised clinical trials
No randomised clinical trials (RCTs) have simultaneously compared the safety of open (OA), transperitoneal laparoscopic (TLA), posterior retroperitoneal (PRA), and robotic adrenalectomy (RA) for resecting adre...
-
Article
The snapshot audit methodology: design, implementation and analysis of prospective observational cohort studies in surgery
For some surgical conditionns and scientific questions, the “real world” effectiveness of surgical patient care may be better explored using a multi-institutional time-bound observational cohort assessment app...
-
Article
Open AccessClinical practice selectively follows acute appendicitis guidelines
Acute appendicitis is a common surgical emergency, and the standard approach to diagnosis and management has been codified in several practice guidelines. Adherence to these guidelines provides insight into in...
-
Article
Open AccessEvaluating utility and feasibility of mismatch repair testing of colorectal cancer patients in a low-middle-income country
Molecular pathology services for colorectal cancer (CRC) in Sudan represent a significant unmet clinical need. In a retrospective cohort study involving 50 patients diagnosed with CRC at three major medical se...
-
Article
Endoscopic management versus transanal surgery for early primary or early locally recurrent rectal neoplasms—a systematic review and meta-analysis
Both endoscopic techniques and transanal surgery are viable options that allow organ preservation for early rectal neoplasms. Whilst endoscopic approaches are less invasive and carry less morbidity, it is uncl...
-
Article
Defining clinicopathological and radiological features of breast cancer in women under the age of 35: an epidemiological study
Breast cancer is the most commonly diagnosed female cancer. Diagnosis in younger women (under 35 years) is different to their older counterparts, and mammography is not considered as sensitive in this cohort. ...
-
Article
The histopathological and molecular features of breast carcinoma with tumour budding—a systematic review and meta-analysis
Tumour budding (TB) is an adverse histological feature in many epithelial cancers. It is thought to represent epithelial–mesenchymal transition, a key step in the metastatic process. The significance of TB in ...
-
Article
Admission of patients with acute urinary retention leads to a definitive management decision
Acute urinary retention (AUR) is a common urologic emergency. However, its management is not standardized due to lack of clinical guidelines.
-
Article
Systematic review and meta-analysis comparing primary resection and anastomosis versus Hartmann’s procedure for the management of acute perforated diverticulitis with generalised peritonitis
Surgical strategies for acute perforated diverticulitis with generalised peritonitis remain controversial. This study aimed to meta-analyse trials comparing primary resection and anastomosis (PRA) to Hartmann’...
-
Article
Strictureplasty versus bowel resection for the surgical management of fibrostenotic Crohn’s disease: a systematic review and meta-analysis
Strictureplasty (SPX) conserves bowel length and minimizes the risk of develo** short bowel syndrome in patients undergoing surgery for Crohn’s disease (CD). However, SPX may be associated with a higher risk...
-
Article
Meta-analysis of early bowel resection versus initial medical therapy in patient's with ileocolonic Crohn's disease
Early bowel resection (EBR) in ileocolonic Crohn’s disease (CD) may be associated with more durable remission compared with initial medical therapy (IMT) even when biologic therapy is included.
-
Article
Systemic inflammatory response predicts oncological outcomes in patients undergoing elective surgery for mismatch repair-deficient colorectal cancer
A variety of inflammatory scoring systems and their prognostic value have been reported in many solid organ cancers. This study aimed to examine the association between the systemic and local inflammatory resp...
-
Article
The prevalence of venous thromboembolism in rectal surgery: a systematic review and meta-analysis
Venous thromboembolism (VTE) following rectal surgery is a significant and preventable cause of morbidity and mortality, yet the true prevalence is not well established. This systematic review and meta-analysi...
