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Article
Comparing neoadjuvant therapy followed by local excision to total mesorectal excision in the treatment of early stage rectal cancer: a systematic review and meta-analysis of randomised clinical trials
Total mesorectal excision (TME) is the standard-of-care in early, clinical stage (cT2-3 N0 M0) rectal cancer. Local excision (LE) may be an alternative after adequate response to neoadjuvant therapy (NAT), wit...
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Article
Open AccessEvaluating the oncological safety of neoadjuvant chemotherapy in locally advanced colon carcinoma: a systematic review and meta-analysis of randomised clinical trials and propensity-matched studies
Use of neoadjuvant chemotherapy (NAC) for locally advanced colon cancer (LACC) remains controversial. An integrated analysis of data from high-quality studies may inform the long-term safety of NAC for this co...
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Article
Impact of model misspecification on model-based tests in PK studies with parallel design: real case and simulation studies
This article evaluates the performance of pharmacokinetic (PK) equivalence testing between two formulations of a drug through the Two-One Sided Tests (TOST) by a model-based approach (MB-TOST), as an alternati...
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Chapter and Conference Paper
Choosing the Most Suitable Classifier for Supporting Assistive Technology Adoption in People with Parkinson’s Disease: A Fuzzy Multi-criteria Approach
Parkinson’s disease (PD) is the second most common neurodegenerative disorder which requires a long-term, interdisciplinary disease management. While there remains no cure for Parkinson’s disease, treatments a...
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Article
Open AccessIndoor localisation through object detection within multiple environments utilising a single wearable camera
The recent growth in the wearable sensor market has stimulated new opportunities within the domain of Ambient Assisted Living, providing unique methods of collecting occupant information. This approach leverag...
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Chapter and Conference Paper
Indoor Localisation Through Object Detection on Real-Time Video Implementing a Single Wearable Camera
This paper presents an accurate indoor localisation approach to provide context aware support for Activities of Daily Living. This paper explores the use of contemporary wearable technology (Google Glass) to f...
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Article
Gene selection and cloning approaches for co-expression and production of recombinant protein–protein complexes
Multiprotein complexes play essential roles in all cells and X-ray crystallography can provide unparalleled insight into their structure and function. Many of these complexes are believed to be sufficiently s...
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Chapter and Conference Paper
Mining for Patterns of Behaviour in Children with Autism Through Smartphone Technology
A requirement to maintain detailed recording of child behaviour is commonplace for families engaged in home-based autism intervention therapy. Periodically, a Behaviour Analyst reviews this data to formulate n...
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Chapter and Conference Paper
From User Requirements to Data: An XML Standard for Structuring Events in Monitored Environments
This paper describes the development and evaluation of a data model to store events that occur within monitored environments. The overall aim is to standardize the transfer of environment events, captured from...
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Chapter and Conference Paper
EasiSocial: An Innovative Way of Increasing Adoption of Social Media in Older People
Online Social Networking has become one of the biggest successes of the Internet. Facebook is the most popular service with over 1.23 billion users. Online Social Networks have the potential to combat feelings...
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Chapter
Using Ontologies for Managing User Profiles in Personalised Mobile Service Delivery
We are now living in a technological world where the adoption of pervasive technologies is becoming more prevalent. This has sparked growth in the development of services for delivery in pervasive environments...
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Chapter and Conference Paper
A Framework for Situation Awareness Based upon Dynamic Situation Modeling
This paper proposes a framework to model dynamically changing situations in real world environments. In the real world, situations naturally vary in how they occur. Understanding these variations is essential ...
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Chapter and Conference Paper
Predicting Technology Adoption in People with Dementia; Initial Results from the TAUT Project
The acceptance of technology is a crucial factor in successfully deploying technology solutions in healthcare. Our previous research has highlighted the potential of modelling user adoption from a range of env...
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Chapter and Conference Paper
Wearable Computing to Support Activities of Daily Living
This paper proposes an approach to determining an occupant’s indoor location through the use of machine vision techniques combined with wearable computing. Based on “off-the-shelf” machine vision tools a syste...
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Chapter and Conference Paper
Investigating Methods for Increasing the Adoption of Social Media amongst Carers for the Elderly
Social Media has become one of the biggest successes on the World Wide Web. The Online Social Network (OSN) Facebook is by far the most popular with over 1 billion users. OSNs have the potential to minimise th...
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Chapter and Conference Paper
Learning Behaviour for Service Personalisation and Adaptation
Context-aware applications within pervasive environments are increasingly being developed as services and deployed in the cloud. As such these services are increasingly required to be adaptive to individual us...
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Chapter
Sixties Britain
This chapter provides a critical survey of recent historical accounts of Sixties Britain, particularly those texts that intersect with wider memory discourses about the Sixties as being a ‘decade of protest’.1 It...
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Chapter
Opportunities and Challenges for Supporting People with Vascular Dementia Through the Use of Common Web 2.0 Services
The aim of this chapter is to present how Web 2.0 technologies can be adapted for Healthcare (Health 2.0). Specifically this will involve explaining the technology and real world scenarios of how this technolo...
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Article
Stakeholder involvement guidelines to improve the design process of assistive technology: lesson from the development of the MPVS system
The Mobile Phone-based Video Streaming (MPVS) system has continually been improved following interaction and evaluation with the relevant stakeholders, primarily lay users, trial managers and developers. Follo...
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Article
The impact of solutions for chronic disease prevention and management
