22 Result(s)

Article

Correction: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2024)

Article

BZW2 promotes malignant progression in lung adenocarcinoma through enhancing the ubiquitination and degradation of GSK3β

The role of Basic leucine zipper and W2 domains 2 (BZW2) in the advancement of different types of tumors is noteworthy, but its involvement and molecular mechanisms in lung adenocarcinoma (LUAD) remain uncerta...

Kai **, Yongmeng Li, Ruyuan Wei, Yanfei Liu, Shuai Wang, Hui Tian in Cell Death Discovery (2024)

Article

Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1

Circular RNAs (circRNAs) have been documented to play crucial roles in the biology of various cancers. However, their investigation in melanoma is still at an early stage, particularly as a broader mechanism b...

Yang Yang, Jianrui Li, Chuanyuan Wei, Lu Wang, Zixu Gao… in Cell Biology and Toxicology (2024)

Article

Decoding the metastatic potential and optimal postoperative adjuvant therapy of melanoma based on metastasis score

Metastasis is a formidable challenge in the prognosis of melanoma. Accurately predicting the metastatic potential of non-metastatic melanoma (NMM) and determining effective postoperative adjuvant treatments fo...

Kangjie Shen, Wenyu Song, Hongye Wang, Lu Wang, Yang Yang… in Cell Death Discovery (2023)

Article

Exosome-derived circKIF20B suppresses gefitinib resistance and cell proliferation in non-small cell lung cancer

The gefitinib resistance mechanism in non-small cell lung cancer (NSCLC) remains unclear, albeit exosomal circular RNA (circRNA) is known to possibly play a vital role in it.

Si-Liang Wei, **g-**g Ye, Li Sun, Lei Hu, Yuan-Yuan Wei… in Cancer Cell International (2023)

Article

Loss of 5-hydroxymethylcytosine induces chemotherapy resistance in hepatocellular carcinoma via the 5-hmC/PCAF/AKT axis

Multidrug resistance is a major challenge in treating advanced hepatocellular carcinoma (HCC). Although recent studies have reported that the multidrug resistance phenotype is associated with abnormal DNA meth...

**ao-Jun Guo, **ao-Yong Huang, Xuan Yang, Jia-Cheng Lu… in Cell Death & Disease (2023)

Article

Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2

Originally discovered in the circulation of pregnant women as a protein secreted by placental trophoblasts, the metalloprotease pregnancy-associated plasma protein A (PAPP-A) is also widely expressed by many o...

Qihang Zhong, Honglei Chu, Guopeng Wang, Cheng Zhang, Rong Li… in Cell Discovery (2022)

Article

c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses

B cells secreting IL-10 functionally are recognized as functional regulatory B (B_reg) cells; however, direct evidence concerning the phenotype, regulation, and functional and clinical relevance of IL-10-secreting...

Xu-Yan Wang, Yuan Wei, Bo Hu, Yuan Liao… in Signal Transduction and Targeted Therapy (2022)

Article

PSMC2 knockdown suppressed tumor progression of skin cutaneous melanoma

Skin cutaneous melanoma (SKCM) is the most lethal tumor among three of the major malignant cancers of the skin. The mechanism underlying the malignant biological behaviors of SKCM is not fully clear. Our study...

Yanwen Yang, Fazhi Qi, Chuanyuan Wei, Jiaqi Liu, Yong Zhang… in Cell Death Discovery (2021)

Article

Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution

Proper development of fetal germ cells (FGCs) is vital for the precise transmission of genetic and epigenetic information through generations. The transcriptional landscapes of human FGC development have been ...

Li Li, Lin Li, Qingqing Li, **xi Liu, **nyi Ma, Jun Yong, Shuai Gao… in Cell Research (2021)

Article

Selective degradation of IKKα by autophagy is essential for arsenite-induced cancer cell apoptosis

Two catalytic subunits of the IKK complex, IKKα and IKKβ, trigger NF-κB activation as well as NF-κB-independent signaling events under both physiological and pathological conditions. Here we identified the NF-...

Qixing Tan, Shuxian Zou, Rui **, Yongliang Hu, Huan Xu… in Cell Death & Disease (2020)

Article

CCL14 serves as a novel prognostic factor and tumor suppressor of HCC by modulating cell cycle and promoting apoptosis

CCL14 is a member of CC chemokines and its role in hepatocellular carcinoma (HCC) is still unknown. In this study, CCL14 expression were analyzed by tissue microarray (TMA) including 171 paired tumor and perit...

Mengxuan Zhu, Weiyue Xu, Chuanyuan Wei, **g Huang, Jietian Xu… in Cell Death & Disease (2019)

Article

Cholecystokinin type B receptor-mediated inhibition of A-type K⁺ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway

Cholecystokinin (CCK) is implicated in the regulation of nociceptive sensitivity of primary afferent neurons. Nevertheless, the underlying cellular and molecular mechanisms remain unknown.

Shumin Yu, Yuan Zhang, **anyang Zhao, Zhigang Chang… in Cell Communication and Signaling (2019)

Article

Bioinformatics-based analysis reveals elevated MFSD12 as a key promoter of cell proliferation and a potential therapeutic target in melanoma

Although recent therapeutic advances based on our understanding of molecular phenomena have prolonged the survival of melanoma patients, the prognosis of melanoma remains dismal and further understanding of th...

Chuan-Yuan Wei, Meng-Xuan Zhu, Nan-Hang Lu, Rui Peng, Xuan Yang, Peng-Fei Zhang… in Oncogene (2019)

Article

Publisher Correction: Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing

In the PDF version of this Resource originally published, on the author list the superscript number 9 to indicate Rui Wang was an equally contributing author was missing owing to a technical error. This has no...

Shuai Gao, Liying Yan, Rui Wang, **gyun Li, Jun Yong, **n Zhou… in Nature Cell Biology (2018)

Article

Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis

The cellular complexity of human brain development has been intensively investigated, although a regional characterization of the entire human cerebral cortex based on single-cell transcriptome analysis has no...

**aoying Fan, Ji Dong, Suijuan Zhong, Yuan Wei, Qian Wu, Liying Yan… in Cell Research (2018)

Article

DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells

Chromatin remodeling is important for the epigenetic reprogramming of human primordial germ cells. However, the comprehensive chromatin state has not yet been analyzed for human fetal germ cells (FGCs). Here w...

Hongshan Guo, Boqiang Hu, Liying Yan, Jun Yong, Yan Wu, Yun Gao, Fan Guo… in Cell Research (2017)

Article

Apigenin, a dietary flavonoid, inhibits proliferation of human bladder cancer T-24 cells via blocking cell cycle progression and inducing apoptosis

Apigenin is a nontoxic dietary flavonoid, and it may have chemopreventive and therapeutic potential as an anti-inflammatory, antioxidant, and anti-cancer agent. However, its role in bladder cancer remains poor...

Ming-Der Shi, Cheng-Kai Shiao, Yi-Chieh Lee, Yuan-Wei Shih in Cancer Cell International (2015)

Article

Galangin, a novel dietary flavonoid, attenuates metastatic feature via PKC/ERK signaling pathway in TPA-treated liver cancer HepG2 cells

Galangin (3,5,7-trihydroxyflavone) is a flavonoid compound found in high concentration in lesser galangal. The objective of this study was to investigate the ability of galangin to inhibit 12-O-tetradecanoylph...

Shang-Tao Chien, Ming-Der Shi, Yi-Chieh Lee, Chou-Chia Te… in Cancer Cell International (2015)

Article

Pinocembrin suppresses TGF-β1-induced epithelial-mesenchymal transition and metastasis of human Y-79 retinoblastoma cells through inactivating αvβ3 integrin/FAK/p38α signaling pathway

Pinocembrin is the most abundant flavonoid in propolis. In this study, we investigated the antimetastatic effect of pinocembrin on TGF-β1-induced epithelial-mesenchymal transition (EMT) and metastasis of human...

Kun-Shiang Chen, Ming-Der Shi, Chi-Sheng Chien, Yuan-Wei Shih in Cell & Bioscience (2014)