28 Result(s)
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Biomedicine
Immunology
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Article
Molecular cloning and characterization of cDNA encoding a novel cytosolic glutathione transferase from Clonorchis sinensis
Glutathione transferases (GSTs) are a group of multifunction isoenzymes coded by many genes. A cDNA encoding a novel cytosolic GST enzyme was cloned from a Clonorchis sinensis (Cs) adult worm cDNA library by larg...
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Clonorchis sinensis: molecular cloning and functional expression of a novel cytosolic glutathione transferase
Glutathione transferases (GSTs) represent a large family of enzymes. In the high throughput sequencing of the cDNA library constructed from the adult stage of Clonorchis sinensis (Cs), we isolate another cDNA clo...
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Open AccessComparative analysis of the alveolar macrophage proteome in ALI/ARDS patients between the exudative phase and recovery phase
Despite decades of extensive studies, the morbidity and mortality for acute lung injury/acute respiratory distress syndrome (ALI/ARDS) remained high. Particularly, biomarkers essential for its early diagnosis ...
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Open AccessThe synergistic effect of homocysteine and lipopolysaccharide on the differentiation and conversion of raw264.7 macrophages
Macrophages play pivotal roles in the progression of atherosclerosis (AS) and their heterogeneous differentiation patterns have been studied extensively. The classical subtype of activated macrophage, M1, prom...
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Open AccessMolecular profile of cochlear immunity in the resident cells of the organ of Corti
The cochlea is the sensory organ of hearing. In the cochlea, the organ of Corti houses sensory cells that are susceptible to pathological insults. While the organ of Corti lacks immune cells, it does have the ...
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Article
Correction: Corrigendum: TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
Nat. Immunol. 15, 676–686 (2014); published online 8 June 2014; corrected after print 21 August 2014 In the version of this article initially published, the labels along the horizontal axes of the graphs Figur...
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Open AccessLack of neuroinflammation in the HIV-1 transgenic rat: an [18F]-DPA714 PET imaging study
HIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive disorders (HAND). In this study, we used micropositron emission tomography (PE...
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Open AccessMicroRNA-106b is involved in transforming growth factor β1–induced cell migration by targeting disabled homolog 2 in cervical carcinoma
MicroRNA-106b (miR-106b) was recently identified as an oncogene participating in cancer progression. Transforming growth factor β1(TGF-β1) is an indispensable cytokine regulating the local microenvironment, th...
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Open AccessInhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer
Prostate cancer (PCa) remains a challenge worldwide. Due to the development of castration-resistance, traditional first-line androgen deprivation therapy (ADT) became powerlessness. Epidermal growth factor rec...
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Open AccessThe effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer
Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and re...
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Open AccessInhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide
Androgen receptor (AR) is expressed in approximately 70% of breast tumors. Recent studies increasingly support AR as a potential therapeutic target of AR-positive breast cancer. We have previously reported tha...
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Open AccessLncRNA HOTAIR-mediated MTHFR methylation inhibits 5-fluorouracil sensitivity in esophageal cancer cells
Esophageal cancer (EC) represents one of the most aggressive digestive neoplasms globally, with marked geographical variations in morbidity and mortality. Chemoprevention is a promising approach for cancer the...
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Open AccessZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis
Among the common preventable cancers of women, cervical cancer has the highest morbidity. It is curable if detected at an early stage. However, reliable diagnostic and prognostic markers, which relate to physi...
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Open AccessRelB upregulates PD-L1 and exacerbates prostate cancer immune evasion
The interaction between programmed death receptor (PD-1) and its ligand (PD-L1) is essential for suppressing activated T-lymphocytes. However, the precise mechanisms underlying PD-L1 overexpression in tumours ...
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Open AccessZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancer due to its highly aggressive phenotype and lack of effective biomarkers or treatment strategies. ZMAT1 belongs to the C2H2 type zinc finge...
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Open AccessIRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation
Reactive astrogliosis usually bears some properties of neural progenitors. How injury triggers astrocyte dedifferentiation remains largely unclear. Here, we report that ischemia induces rapid up-regulation of ...
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Open AccessElesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy
Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past, elesclomol was recognized as an inducer of oxidative stress, but now it has also been found to suppress cancer by inducing c...
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Open AccessTregs dysfunction aggravates postoperative cognitive impairment in aged mice
Enhanced neuroinflammation is an important mechanism underlying perioperative neurocognitive disorders. Regulatory T cells (Tregs) play a crucial role in regulating systemic immune responses. The present study...
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Open AccessMolecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition
Despite progress in develo** wound care strategies, there is currently no treatment that promotes the self-tissue repair capabilities. H2 has been shown to effectively protect cells and tissues from oxidative a...
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Open AccessCombination of RUNX1 inhibitor and gemcitabine mitigates chemo‐resistance in pancreatic ductal adenocarcinoma by modulating BiP/PERK/eIF2α-axis-mediated endoplasmic reticulum stress
Gemcitabine (GEM)-based chemotherapy is the first-line option for pancreatic ductal adenocarcinoma (PDAC). However, the development of drug resistance limits its efficacy, and the specific mechanisms remain la...
