8 Result(s)
within
**nyuan Ren
Life Sciences
Cell Biology
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Article
Open AccessTudor-SN promotes cardiomyocyte proliferation and neonatal heart regeneration through regulating the phosphorylation of YAP
The neonatal mammalian heart exhibits considerable regenerative potential following injury through cardiomyocyte proliferation, whereas mature cardiomyocytes withdraw from the cell cycle and lose regenerative ...
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Article
Open AccessVascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia
Vascular smooth muscle cell (VSMC) proliferation is the leading cause of vascular stenosis or restenosis. Therefore, investigating the molecular mechanisms and pivotal regulators of the proliferative VSMC phen...
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Article
Open AccessA novel c-Met/TRK inhibitor 1D228 efficiently inhibits tumor growth by targeting angiogenesis and tumor cell proliferation
Multiple tumors are synergistically promoted by c-Met and TRK, and blocking their cross-signalling pathway may give better effects. In this study, we developed a tyrosine kinase inhibitor 1D228, which exhibite...
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Article
Open AccessArginase: shedding light on the mechanisms and opportunities in cardiovascular diseases
Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform significant roles in the regulation o...
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Article
Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress
Herein, Tudor-SN was identified as a DNA damage response (DDR)-related protein that plays important roles in the early stage of DDR. X-ray or laser irradiation could evoke the accumulation of Tudor-SN to DNA d...
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Chapter
Epigenetic Regulation of Plant Heat Shock Protein (HSP) Gene Expression
Heat shock proteins (HSPs) are the key components of plants’ adaptive mechanism to maintain protein homeostasis. HSPs play critical roles not only in response to unfavorable environmental conditions, but also ...
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Article
Differential profiling analysis of miRNAs reveals a regulatory role in low N stress response of Populus
Nitrogen (N) is an essential mineral element for plant growth processes, and its availability severely affects the productivity of plants, especially trees. MicroRNAs (miRNAs) are a class of non-coding RNAs ap...
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Article
Identification of novel and conserved Populus tomentosa microRNA as components of a response to water stress
MicroRNAs (miRNAs) are a class of small, non-coding RNAs that play important downregulation roles in plants growth, development, and stress responses. To better identify Populus tomentosa miRNAs and understand th...
