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Life Sciences
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Article
Open AccessCorrection: Comparative analysis of chloroplast genomes of Pulsatilla species reveals evolutionary and taxonomic status of newly discovered endangered species Pulsatilla saxatilis
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Open AccessALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration
N6-methyladenosine (m6A) methylation is a prevalent RNA modification implicated in various diseases. However, its role in intervertebral disc degeneration (IDD), a common cause of low back pain, remains unclear.
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Open AccessSuper-resolution imaging of T lymphocyte activation reveals chromatin decondensation and disrupted nuclear envelope
T lymphocyte activation plays a pivotal role in adaptive immune response and alters the spatial organization of nuclear architecture that subsequently impacts transcription activities. Here, using stochastic o...
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Application of Repetitive Sequences in Fish Cell Depletion as a Target for the CRISPR/Cas9 System
Specific cell depletion is a common means to study the physiological function of cell lineages and tissue regeneration. However, 100% depletion is difficult to achieve with existing cell depletion strategies. ...
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Abandoned, lost, and otherwise discarded fishing gear in world’s inland fisheries
Abandoned, lost, and discarded fishing gear (ALDFG) is a problem that is increasingly of concern to global fisheries resources and the aquatic environment. Nearly 2% of all fishing gear used in marine fisherie...
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Transcriptome Analysis of Different Aquaculture Substrates on the Immune Response of Babylonia areolata
To assess the impact of different substrates in a recirculating water system on the immune response and antioxidant capacity of Babylonia areolata, we conducted a comparative analysis of the transcriptomes and an...
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Computational study on the binding mechanism of allosteric drug TNO155 inhibiting SHP2E76A
E76A mutations of SHP2 have been reported to associate with genetic developmental diseases and cancers, and TNO155 is one of the effective inhibitors targeted to the allosteric site 1, which has already entered t...
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The conversion of monolignans to sesquilignans and dilignans is closely correlated to the regulation of Arctium lappa seed germination
The secondary metabolic conversion of monolignans to sesquilignans/dilignans was closely related to seed germination and seedling establishment in Arctium lappa.
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Open AccessSqualene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB
While de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular mechanism remains poorly understood.
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Open AccessThe NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif
PTENα/β, two variants of PTEN, play a key role in promoting tumor growth by interacting with WDR5 through their N-terminal extensions (NTEs). This interaction facilitates the recruitment of the SET1/MLL methyl...
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Open AccessAn electrophoretic mobility shift assay using the protein isolated from host plants
The electrophoretic mobility shift assay (EMSA) is a common technology to detect DNA-protein interactions. However, in most cases, the protein used in EMSA is obtained via prokaryotic expression, and rarely fr...
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Open AccessMSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism
MiRNAs in mesenchymal stem cells (MSCs)-derived exosome (MSCs-exo) play an important role in the treatment of sepsis. We explored the mechanism through which MSCs-exo influences cognitive impairment in sepsis-...
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Gene-knockout by iSTOP enables rapid reproductive disease modeling and phenoty** in germ cells of the founder generation
Cytosine base editing achieves C•G-to-T•A substitutions and can convert four codons (CAA/CAG/CGA/TGG) into STOP-codons (induction of STOP-codons, iSTOP) to knock out genes with reduced mosaicism. iSTOP enables...
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Open AccessTwo putative calcium-dependent protein kinases are involved in the regulation of sugarcane defense genes
Sugarcane is a primary sugar crop and an important source of bioenergy. Pathogens are the major factors affecting sugarcane yield and sugar content. However, the mechanisms of sugarcane defense regulation rema...
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Open AccessTIP aquaporins in Cyperus esculentus: genome-wide identification, expression profiles, subcellular localizations, and interaction patterns
Tonoplast intrinsic proteins (TIPs), which typically mediate water transport across vacuolar membranes, play an essential role in plant growth, development, and stress responses. However, their characterizatio...
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Open AccessComparative analysis of chloroplast genomes of Pulsatilla species reveals evolutionary and taxonomic status of newly discovered endangered species Pulsatilla saxatilis
Pulsatilla saxatilis, a new species of the genus Pulsatilla has been discovered. The morphological information of this species has been well described, but its chloroplast genome characteristics and comparison wi...
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Open AccessEpiberberine: a potential rumen microbial urease inhibitor to reduce ammonia release screened by targeting UreG
Rumen microbial urease inhibitors have been proposed for regulating nitrogen emission and improving nitrogen utilization efficiency in ruminant livestock industry. However, studies on plant-derived natural inh...
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Nitrogen deposition mediates more stochastic processes in structuring plant community than soil microbial community in the Eurasian steppe
Anthropogenic environmental changes may affect community assembly through mediating both deterministic (e.g., competitive exclusion and environmental filtering) and stochastic processes (e.g., birth/death and ...
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Effect of calcium ions on the interaction of alkaline minerals with dissolved organic matter: Implications for organic carbon sequestration in bauxite residue
The interaction of minerals and organic matter significantly affects the stability of organic carbon, which is key to the rehabilitation of bauxite residue. However, due to the microscopic structure of mineral...
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Organic amendments enhanced the humification degree in soil formation of bauxite residue
Revegetation of bauxite residue disposal areas is an effective disposal strategy for large-scale in-situ disposal and reduction of environmental risk. The application of organic amendments is an effective meth...
