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Article
Open AccessLiver fibrosis as a predictor of liver failure and outcome following ALPPS among patients with primary liver cancer
The influence of liver fibrosis on the rate of liver regeneration and complications following ALPPS has yet to be fully understood. This study aimed to scrutinize the effects of liver fibrosis on the postopera...
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Article
Open AccessStructural basis for hyperpolarization-dependent opening of human HCN1 channel
Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the automaticity of action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage...
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Article
Open AccessDevelo** an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies
Early detection of colorectal neoplasms can reduce the colorectal cancer (CRC) burden by timely intervention for high-risk individuals. However, effective risk prediction models are lacking for personalized CR...
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Article
Open AccessCoHIT: a one-pot ultrasensitive ERA-CRISPR system for detecting multiple same-site indels
Genetic testing is crucial for precision cancer medicine. However, detecting multiple same-site insertions or deletions (indels) is challenging. Here, we introduce CoHIT (Cas12a-based One-for-all High-speed Is...
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Article
Open AccessIFI16 promotes the progression of clear cell renal cell carcinoma through the IL6/PI3K/AKT axis
Clear cell renal cell carcinoma (ccRCC) is a common disease in the urinary system, with a high incidence and poor prognosis in advanced stages. Although γ-interferon-inducible protein 16 (IFI16) has been repor...
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Article
Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
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Article
Open AccessEstablishment and application of a rapid visual diagnostic method for Streptococcus agalactiae based on recombinase polymerase amplification and lateral flow strips
This study aims to establish a rapid diagnostic method for Streptococcus agalactiae (GBS) based on recombinase polymerase amplification (RPA) and lateral flow strips (LFS). The best primer pairs designed by SIP g...
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Article
Open AccessSwine acute diarrhea syndrome coronavirus Nsp1 suppresses IFN-λ1 production by degrading IRF1 via ubiquitin–proteasome pathway
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel porcine enteric coronavirus that causes acute watery diarrhea, vomiting, and dehydration in newborn piglets. The type III interferon (IFN-λ) resp...
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Article
Open AccessExercise intervention in middle-aged and elderly individuals with insomnia improves sleep and restores connectivity in the motor network
Exercise is a potential treatment to improve sleep quality in middle-aged and elderly individuals. Understanding exercise-induced changes in functional plasticity of brain circuits that underlie improvements i...
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Article
Open AccessClinical evidence for efficacy of pembrolizumab in MSI-H and TMB-H advanced solid tumor: results from three cancer centers in China
Pembrolizumab has been indicated in the treatment of solid tumors with high frequency microsatellite instability (MSI-H) or high tumor mutational burden (TMB-H); however, real-world data on the effectiveness o...
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Article
Open AccessDevelopment of a CRISPR-Cas12a based assay for the detection of swine enteric coronaviruses in pig herds in China
Porcine epidemic diarrhea virus (PEDV), Transmissible gastroenteritis virus (TGEV), Porcine deltacoronavirus (PDCoV) and Swine acute diarrhea syndrome coronavirus (SADS-CoV) rank among the most frequently enco...
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Article
Open AccessIn situ copper faceting enables efficient CO2/CO electrolysis
The copper (Cu)-catalyzed electrochemical CO2 reduction provides a route for the synthesis of multicarbon (C2+) products. However, the thermodynamically favorable Cu surface (i.e. Cu(111)) energetically favors si...
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Article
Open AccessUnraveling the causality between chronic obstructive pulmonary disease and its common comorbidities using bidirectional Mendelian randomization
Chronic obstructive pulmonary disease (COPD) frequently coexists with various diseases, yet the causal relationship between COPD and these comorbidities remains ambiguous. As a result, the aim of our study is ...
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Article
Open AccessLeCaSiM: Learning Causal Structure via Inverse of M-Matrices with Adjustable Coefficients
The objective of causal discovery is to uncover the causal relationships among natural phenomena or human behaviors, thus establishing the basis for subsequent prediction and inference. Traditional ways to rev...
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Article
Open AccessDesign Strategies for Aqueous Zinc Metal Batteries with High Zinc Utilization: From Metal Anodes to Anode-Free Structures
Representative methods for calculating the depth of discharge of different Zn anodes are introduced.
Recent advances of aque...
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Chapter and Conference Paper
A Machine-Vision-Based Hub Location Detection Technique for Installing Wind Turbines
A position detection approach based on machine vision is developed to address the issue that the traditional wind turbine hub lifting procedure relies on the location of engineers and cannot provide quick feed...
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Chapter and Conference Paper
Rigid-Flexible Coupling Dynamics Analysis of Boom-Hoisting System of Wind Power Crane
Based on the slenderness of wind power crane boom and the complexity of working environment, a mathematical model of rigid-flexible coupling dynamics including wind load and vibration characteristic analysis i...
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Article
Open AccessIntegration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN,...
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Article
Open AccessStructural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8
The C-C motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has appeared to be an attractive ...
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Article
Open AccessPhase patterning of metallic glasses through superfast quenching of ion irradiation-induced thermal spikes
Amorphous metallic glasses (MGs) convert to crystalline solids upon annealing at a high temperature. Such a phase change, however, does not occur with the local melting caused by damage cascades introduced by ...
