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Article
Multi-scale detector optimized for small target
The effectiveness of deep learning networks in detecting small objects is limited, thereby posing challenges in addressing practical object detection tasks. In this research, we propose a small object detectio...
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Article
Open AccessIntegration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN,...
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Article
Discovery of novel and potent InhA direct inhibitors by ensemble docking-based virtual screening and biological assays
Multidrug-resistant tuberculosis (MDR-TB) continues to spread worldwide and remains one of the leading causes of death among infectious diseases. The enoyl-acyl carrier protein reductase (InhA) belongs to FAS-...
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Article
Effect of Alumina Replacing Calcium Oxide on Vitrification of Molybdenum in Borosilicate Glass
Borosilicate glasses are the most potential matrices to vitrify high-level nuclear wastes. However, the low solubility of Mo, which is usually one of the main elements in HLWs coming from the nuclear power sta...
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Article
Open AccessChromatin organizer SATB1 controls the cell identity of CD4+ CD8+ double-positive thymocytes by regulating the activity of super-enhancers
CD4+ and CD8+ double-positive (DP) thymocytes play a crucial role in T cell development in the thymus. DP cells rearrange the T cell receptor gene Tcra to generate T cell receptors with TCRβ. DP cells differentia...
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Article
A Construction of Representations of Loop Group and Affine Lie Algebra of \(\frak {sl}_{n}\)
We construct a family of representations of a central extension of loop group and affine Lie algebra for ...
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Article
Open AccessPhase separation of Epstein-Barr virus EBNA2 protein reorganizes chromatin topology for epigenetic regulation
Epstein-Barr virus nuclear antigen 2 (EBNA2) is a transactivator of viral and cellular gene expression, which plays a critical role in the Epstein-Barr virus-associated diseases. It was reported that EBNA2 reg...
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Article
Open AccessDownregulation by CNNM2 of ATP5MD expression in the 10q24.32 schizophrenia-associated locus involved in impaired ATP production and neurodevelopment
Genome-wide association studies (GWAS) have accelerated the discovery of numerous genetic variants associated with schizophrenia. However, most risk variants show a small effect size (odds ratio (OR) <1.2), su...
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Article
Discovery of small molecules binding to the normal conformation of prion by combining virtual screening and multiple biological activity evaluation methods
Conformational conversion of the normal cellular prion protein, PrPC, into the misfolded isoform, PrPSc, is considered to be a central event in the development of fatal neurodegenerative diseases. Stabilization o...
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Article
Studies on high-temperature thermal transformation and dielectric property of aluminum–chromium phosphates
High-temperature thermal transformation of aluminum–chromium phosphates has been investigated by means of DSC–TG, IR, and XRD analysis. The relative dielectric constant and thermal decomposition were measured ...
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Article
Global vertex operators on Riemann surfaces
We develop an approach towards construction of conformal field theory starting from the basic axioms of vertex operator algebras.
