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Article
Investigation of the parallel gradation method based on response of ballast penetration into subgrade soil by discrete element method
Treating ballast and subgrade soil as an integrated unit for sampling and loading has proven to be an effective method for investigating the interaction between ballast and subgrade soil. Given that direct tes...
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Article
Open AccessLiver fibrosis as a predictor of liver failure and outcome following ALPPS among patients with primary liver cancer
The influence of liver fibrosis on the rate of liver regeneration and complications following ALPPS has yet to be fully understood. This study aimed to scrutinize the effects of liver fibrosis on the postopera...
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Article
Recent advances and perspectives in MXene-based cathodes for aqueous zinc-ion batteries
Aqueous zinc-ion batteries (AZIBs) show great potential for applications in grid-scale energy storage, given their intrinsic safety, cost effectiveness, environmental friendliness, and impressive electrochemic...
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Article
High-Temperature Fatigue Behavior of Inertia Friction Welded Joints of GH4065A Ni-Based Superalloy
In this work, the novel Ni-based superalloy GH4065A inertia friction welding (IFW) joints were subjected to the post-welding heat treatments (PWHT) at 730 ℃ for 5 h or 760 ℃ for 5 h, and the differences in mic...
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Article
Open AccessStructural basis for hyperpolarization-dependent opening of human HCN1 channel
Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the automaticity of action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage...
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Article
Open AccessDevelo** an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies
Early detection of colorectal neoplasms can reduce the colorectal cancer (CRC) burden by timely intervention for high-risk individuals. However, effective risk prediction models are lacking for personalized CR...
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Article
Open AccessCoHIT: a one-pot ultrasensitive ERA-CRISPR system for detecting multiple same-site indels
Genetic testing is crucial for precision cancer medicine. However, detecting multiple same-site insertions or deletions (indels) is challenging. Here, we introduce CoHIT (Cas12a-based One-for-all High-speed Is...
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Article
Open AccessIFI16 promotes the progression of clear cell renal cell carcinoma through the IL6/PI3K/AKT axis
Clear cell renal cell carcinoma (ccRCC) is a common disease in the urinary system, with a high incidence and poor prognosis in advanced stages. Although γ-interferon-inducible protein 16 (IFI16) has been repor...
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Article
Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
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Article
CT radiomics including lesion-surrounding regions for distinguishing pulmonary cryptococcosis from lung cancer
Pulmonary cryptococcosis (PC) is a fungal lung disease, and nodule/mass-type PC can exhibit imaging findings similar to lung cancer (LC). This study aimed to develop and externally test a new radiomics model b...
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Article
Redifferentiation of genetically modified dedifferentiated chondrocytes in a microcavitary hydrogel
We genetically modified dedifferentiated chondrocytes (DCs) using lentiviral vectors and adenoviral vectors encoding TGF-β3 (referred to as transgenic groups below) and encapsulated these DCs in the microcavit...
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Article
Improving Tensile Properties of Dissimilar TLP Bonding Joints of IN718 Nickel-Based Superalloy/316LN Austenitic Steel by Long-Term Post-bonded Homogenization Treatment
The presence of boride precipitates has a detrimental impact on the mechanical properties of TLP bonding joints. This study investigated the effectiveness of the long-term post-bonded homogenization treatment ...
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Article
Open AccessEstablishment and application of a rapid visual diagnostic method for Streptococcus agalactiae based on recombinase polymerase amplification and lateral flow strips
This study aims to establish a rapid diagnostic method for Streptococcus agalactiae (GBS) based on recombinase polymerase amplification (RPA) and lateral flow strips (LFS). The best primer pairs designed by SIP g...
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Article
Improving creep strength of the fine-grained heat-affected zone of novel 9Cr martensitic heat-resistant steel via modified thermo-mechanical treatment
The infamous type IV failure within the fine-grained heat-affected zone (FGHAZ) in G115 steel weldments seriously threatens the safe operation of ultra-supercritical (USC) power plants. In this work, the tradi...
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Article
Open AccessSwine acute diarrhea syndrome coronavirus Nsp1 suppresses IFN-λ1 production by degrading IRF1 via ubiquitin–proteasome pathway
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel porcine enteric coronavirus that causes acute watery diarrhea, vomiting, and dehydration in newborn piglets. The type III interferon (IFN-λ) resp...
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Article
Multi-scale detector optimized for small target
The effectiveness of deep learning networks in detecting small objects is limited, thereby posing challenges in addressing practical object detection tasks. In this research, we propose a small object detectio...
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Article
Synergistic effect of Gd and Sr on the microstructure and mechanical properties of Al–Si–Mg alloy
Al–Si–Mg alloys have received widespread application in communication, transportation and other fields on account of their attractive properties, e.g. superior castability, high ductility and excellent corrosi...
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Article
Open AccessExercise intervention in middle-aged and elderly individuals with insomnia improves sleep and restores connectivity in the motor network
Exercise is a potential treatment to improve sleep quality in middle-aged and elderly individuals. Understanding exercise-induced changes in functional plasticity of brain circuits that underlie improvements i...
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Article
Clinical risk prediction model and external validation of positive surgical margin in laparoscopic radical prostatectomy based on MRI lesion location
To clarify the composition of lesions in different magnetic resonance imaging (MRI) partitions of positive surgical margins (PSM) after laparoscopic radical prostatectomy, explore the influence of lesion locat...
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Article
Open AccessClinical evidence for efficacy of pembrolizumab in MSI-H and TMB-H advanced solid tumor: results from three cancer centers in China
Pembrolizumab has been indicated in the treatment of solid tumors with high frequency microsatellite instability (MSI-H) or high tumor mutational burden (TMB-H); however, real-world data on the effectiveness o...
