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Article
Open AccessExploring the oncogenic potential of circSOD2 in clear cell renal cell carcinoma: a novel positive feedback loop
Existing studies have found that circular RNAs (circRNAs) act as sponges for micro RNAs (miRNAs) to control downstream genes. However, the specific functionalities and mechanisms of circRNAs in human clear cel...
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Article
Molecular docking-aided AIEgen design: concept, synthesis and applications
Aggregate-induced emission luminogens (AIEgens) have been widely used in biological imaging, chemical sensing, and disease treatments. The rational design and construction of AIEgens have received considerable...
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Article
Open AccessDNA methylation variations underlie lettuce domestication and divergence
Lettuce (Lactuca sativa L.) is an economically important vegetable crop worldwide. Lettuce is believed to be domesticated from a single wild ancestor Lactuca serriola and subsequently diverged into two major morp...
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Article
Multidimensional hollow SiO2/C nanofibers modified by magnetic nanocrystals for electromagnetic energy conversion and lithium battery storage
Multifunctional materials are powerful tools to support the advancement of energy conversion devices. Materials with prominent electromagnetic and electrochemical properties can realize the conversion of elect...
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Article
Open AccessBright X/ \(\gamma\) -ray emission and lepton pair production by strong laser fields: a review
The advent of high-power ultra-short laser pulses opens up new frontiers of relativistic non-linear optics, high energy density physics and laboratory astrophysics. As the laser electric field in the particle ...
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Article
MYPT1SMKO Mice Function as a Novel Spontaneous Age- and Hypertension-Dependent Animal Model of CSVD
Cerebral small vessel disease (CSVD) is the most common progressive vascular disease that causes vascular dementia. Aging and hypertension are major contributors to CSVD, but the pathophysiological mechanism r...
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Article
Open AccessImperceptible augmentation of living systems with organic bioelectronic fibres
The functional and sensory augmentation of living structures, such as human skin and plant epidermis, with electronics can be used to create platforms for health management and environmental monitoring. Ideall...
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Article
Open AccessDevelopment and validation of a nomogram to predict postoperative delirium in older patients after major abdominal surgery: a retrospective case-control study
Postoperative delirium is a common complication in older patients, with poor long-term outcomes. This study aimed to investigate risk factors and develop a predictive model for postoperative delirium in older ...
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Article
Open AccessAnalysis of nearly 3000 archaeal genomes from terrestrial geothermal springs sheds light on interconnected biogeochemical processes
Terrestrial geothermal springs are physicochemically diverse and host abundant populations of Archaea. However, the diversity, functionality, and geological influences of these Archaea are not well understood....
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Article
Open AccessBiosynthetic production of anticoagulant heparin polysaccharides through metabolic and sulfotransferases engineering strategies
Heparin is an important anticoagulant drug, and microbial heparin biosynthesis is a potential alternative to animal-derived heparin production. However, effectively using heparin synthesis enzymes faces challe...
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Article
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis
Colorectal cancer (CRC) is a prevalent form of gastrointestinal malignancy with challenges in chemotherapy resistance and side effects. Effective and low toxic drugs for CRC treatment are urgently needed. Ferr...
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Article
Open AccessPurines enrich root-associated Pseudomonas and improve wild soybean growth under salt stress
The root-associated microbiota plays an important role in the response to environmental stress. However, the underlying mechanisms controlling the interaction between salt-stressed plants and microbiota are po...
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Article
Integrated Biofilm Modification and Transcriptional Analysis for Improving Fengycin Production in Bacillus amyloliquefaciens
Although fengycin exhibits broad-spectrum antifungal properties, its application is hindered due to its low biosynthesis level and the co-existence of iturin A and surfactin in Bacillus amyloliquefaciens HM618, a...
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Article
Cloning of CAT genes in Satsuma mandarin and their expression characteristics in response to environmental stress and arbuscular mycorrhizal fungi
CitCAT1 and CitCAT2 were cloned and highly expressed in mature leaves. High temperatures up-regulated CitCAT1 expression, while low temperatures and Diversispora versiformis up-regulated CitCAT2 expression, maint...
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Article
Topological Kerr effects in two-dimensional magnets with broken inversion symmetry
The whorls of localized moments in chiral magnetic structures, such as skyrmions, lead to a quantized topological charge, which may make them useful as next-generation information bits. So far, the most reliab...
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Article
Modulated noble metal/2D MOF heterostructures for improved hydrogen storage of MgH2
The conjugation of external species with two-dimensional (2D) materials has broad application prospects. In this study, we have explored the potential of noble metal/2D MOF heterostructures in hydrogen storage...
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Article
Open AccessCryo-EM structures of Banna virus in multiple states reveal stepwise detachment of viral spikes
Banna virus (BAV) is the prototype Seadornavirus, a class of reoviruses for which there has been little structural study. Here, we report atomic cryo-EM structures of three states of BAV virions—surrounded by 120...
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Article
Open AccessPMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness
Host survival depends on the elimination of virus and mitigation of tissue damage. Herein, we report the modulation of D-mannose flux rewires the virus-triggered immunometabolic response cascade and reduces ti...
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Article
Open AccessLncRNA LUESCC promotes esophageal squamous cell carcinoma by targeting the miR-6785-5p/NRSN2 axis
Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent gastrointestinal malignancies with high mortality worldwide. Emerging evidence indicates that long noncoding RNAs (lncRNAs) are involved i...
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Article
Open AccessCircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma
The oncogenic role of circRNA in cancers including esophageal cancer (EC) has been well studied. However, whether and how circRNAs are involved in cancer cell metabolic processes remains largely unknown. Here,...
