90 Result(s)

Article

Discovery of Loureirin analogues with colorectal cancer suppressive activity via regulating cell cycle and Fas death receptor

Chalcones and dihydrochalcones (DHCs) are important bioactive natural products (BNPs) isolated from traditional Chinese medicine. In this study, 13 chalcones were designed with the inspiration of Loureirin, a ...

Peng Li, **angjuan Tian, Die Zhang, Hui** Ou… in BMC Pharmacology and Toxicology (2024)

Article

Lysine acetyltransferase 14 mediates TGF-β-induced fibrosis in ovarian endometrioma via co-operation with serum response factor

Fibrogenesis within ovarian endometrioma (endometrioma), mainly induced by transforming growth factor-β (TGF-β), is characterized by myofibroblast over-activation and excessive extracellular matrix (ECM) depos...

Yi Gong, Mian Liu, Qianqian Zhang, ****g Li… in Journal of Translational Medicine (2024)

Article

Screening and diagnosis of cardiovascular disease using artificial intelligence-enabled cardiac magnetic resonance imaging

Cardiac magnetic resonance imaging (CMR) is the gold standard for cardiac function assessment and plays a crucial role in diagnosing cardiovascular disease (CVD). However, its widespread application has been l...

Yan-Ran (Joyce) Wang, Kai Yang, Yi Wen, Pengcheng Wang, Yuepeng Hu… in Nature Medicine (2024)

Article

A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway

Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer with high aggressive phenotype and poor prognosis. Accumulating evidence suggests that circRNAs have been identified as pivotal media...

Bo Huang, Junwu Ren, Qiang Ma, Feifei Yang, **aojuan Pan, Yuying Zhang… in Molecular Cancer (2024)

Article

Co-transfer of IncFII/IncFIB and IncFII plasmids mediated by IS26 facilitates the transmission of mcr-8.1 and tmexCD1-toprJ1

This study aimed to characterise the whole-genome structure of two clinical Klebsiella pneumoniae strains co-harbouring mcr-8.1 and tmexCD1-toprJ1, both resistant to colistin and tigecycline.

Qian Wang, Meng Zhang, Yue Liu, **mei Li… in Annals of Clinical Microbiology and Antimi… (2024)

Article

A deep learning system for predicting time to progression of diabetic retinopathy

Diabetic retinopathy (DR) is the leading cause of preventable blindness worldwide. The risk of DR progression is highly variable among different individuals, making it difficult to predict risk and personalize...

Ling Dai, Bin Sheng, Tingli Chen, Qiang Wu, Ruhan Liu, Chun Cai… in Nature Medicine (2024)

Article

A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK

Inhibiting MerTK on macrophages is a promising therapeutic strategy for augmenting anti-tumor immunity. However, blocking MerTK on retinal pigment epithelial cells (RPEs) results in retinal toxicity. Bispecifi...

Ran Li, Edward Dere, Mandy Kwong, Mingjian Fei, Rutwij Dave… in The AAPS Journal (2024)

Article

Voluntary running wheel exercise induces cognitive improvement post traumatic brain injury in mouse model through redressing aberrant excitation regulated by voltage-gated sodium channels 1.1, 1.3, and 1.6

Traumatic brain injury (TBI) leads to disturbed brain discharge rhythm, elevated excitability, anxiety-like behaviors, and decreased learning and memory capabilities. Cognitive dysfunctions severely affect the...

Dan Wang, Hui-**ang Zhang, Guo-Ji Yan, Hao-Ran Zhao… in Experimental Brain Research (2024)

Article

Analysis of myosin genes in HNSCC and identify MYL1 as a specific poor prognostic biomarker, promotes tumor metastasis and correlates with tumor immune infiltration in HNSCC

Head neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors which ranks the sixth incidence in the world. Although treatments for HNSCC have improved significantly in recent years, its...

Ce Li, Rui Guan, Wenming Li, Dongmin Wei, Shengda Cao, Fen Chang, Qun Wei… in BMC Cancer (2023)

Article

Multiple Immune Defects in Two Patients with Novel DOCK2 Mutations Result in Recurrent Multiple Infection Including Live Attenuated Virus Vaccine

The dedicator of cytokinesis 2(DOCK2) protein, an atypical guanine nucleotide exchange factor (GEFs), is a member of the DOCKA protein subfamily. DOCK2 protein deficiency is characterized by early-onset lympho...

Wenhui Li, Yuting Sun, Lang Yu, Ran Chen, Rui Gan… in Journal of Clinical Immunology (2023)

Article

Correction: Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway

Ruo-Nan Duan, Chun-Lin Yang, Tong Du, Ai Liu, An-Ran Wang… in Journal of Neuroinflammation (2023)

Article

Glycyrrhiza polysaccharides inhibits PRRSV replication

Glycyrrhiza polysaccharide (GCP) is a natural plant active polysaccharide extracted from traditional Chinese medicine licorice. In this research, we studied the antiviral activity of glycyrrhiza polysaccharide...

Youbing Yang, Yongjian Liu, Ran Lou, Ying Lei, Gan Li, Zhiqian Xu… in Virology Journal (2023)

Article

Botulinum neurotoxin A ameliorates depressive-like behavior in a reserpine-induced Parkinson’s disease mouse model via suppressing hippocampal microglial engulfment and neuroinflammation

Depression is one of the common non-motor symptoms of Parkinson’s disease (PD). In the clinic, botulinum neurotoxin A (BoNT/A) has been used to treat depression. In this study, we investigated the mechanisms u...

Yang Li, Qiao Yin, Qi Li, An-ran Huo, Ting-ting Shen… in Acta Pharmacologica Sinica (2023)

Article

High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis

PTPRF interacting protein alpha 1 (PPFIA1) is reportedly related to the occurrence and progression of several kinds of malignancies. However, its role in esophageal squamous cell carcinoma (ESCC) is unclear. T...

Yongyin Gao, Lizhao Guan, Ran Jia, Wanyi **ao, Youming Han, Yue Li, Peng Tang… in BMC Cancer (2023)

Article

Microfat exerts an anti-fibrotic effect on human hypertrophic scar via fetuin-A/ETV4 axis

Hypertrophic scar is a fibrotic disease following wound healing and is characterized by excessive extracellular matrix deposition. Autologous microfat grafting proves an effective strategy for the treatment th...

Qian Yu, Qiang Dai, Zonglin Huang, Chen Li, Li Yan… in Journal of Translational Medicine (2023)

Article

A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis

Metastasis is the leading cause of mortality in patients with breast cancer (BC). Studies demonstrate that circular RNAs (circRNAs) were involved in BC progression, while the molecular mechanisms remain largel...

Ran Hao, Lei Zhang, Yangming Si, Peng Zhang, Yipeng Wang… in Cancer Cell International (2023)

Article

Increased retinoic acid signaling decreases lung metastasis in salivary adenoid cystic carcinoma by inhibiting the noncanonical Notch1 pathway

MYB-NFIB fusion and NOTCH1 mutation are common hallmark genetic events in salivary gland adenoid cystic carcinoma (SACC). However, abnormal expression of MYB and NOTCH1 is also observed in patients without MYB-NF...

Meng-jiao Zhou, Jia-jie Yang, Ting-yao Ma… in Experimental & Molecular Medicine (2023)

Article

Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer

Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could aff...

Ao-ran Liu, Zhi Lv, Zi-wei Yan, … in Journal of Translational Medicine (2023)

Article

Concurrent definitive chemoradiation incorporating intensity-modulated radiotherapy followed by adjuvant chemotherapy in high risk locally advanced cervical squamous cancer: a phase II study

Although the prognosis of locally advanced cervical cancer has improved dramatically, survival for those with stage IIIB-IVA disease or lymph nodes metastasis remains poor. It is believed that the incorporatio...

Gong-yi Zhang, Rong Zhang, ** Bai, Shu-min Li, Yuan-yuan Zhang, Yi-ran Chen… in BMC Cancer (2022)

Article

Tubular epithelial cells-derived small extracellular vesicle-VEGF-A promotes peritubular capillary repair in ischemic kidney injury

Peritubular capillaries (PTCs) are closely related to renal tubules in structure and function, and both are pivotal regulators in the development and progression of acute kidney injury (AKI). However, the mech...

**n Zhong, Tao-Tao Tang, An-Ran Shen, **g-Yuan Cao, **g **g… in npj Regenerative Medicine (2022)