15 Result(s)

Article

Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation

Hematopoietic stem and progenitor cells (HSPCs) that have impaired differentiation can transform into leukemic blasts. However, the mechanism that controls differentiation remains elusive. Here, we show that t...

Huan Liu, Lu Sun, Hongfei Zhao, Zihan Zhao, Shiyue Zhang… in Cell Death & Differentiation (2024)

Article

The OGT–c-Myc–PDK2 axis rewires the TCA cycle and promotes colorectal tumor growth

Deregulated glucose metabolism termed the “Warburg effect” is a fundamental feature of cancers, including the colorectal cancer. This is typically characterized with an increased rate of glycolysis, and a conc...

Huijuan Wang, Jie Sun, Haofan Sun, Yifei Wang, Bingyi Lin… in Cell Death & Differentiation (2024)

Article

CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that affects social interaction and behavior. Mutations in the gene encoding chromodomain helicase DNA-binding protein 8 (CHD8) lead to ...

Bang Li, Hui Zhao, Zhuchi Tu, Weili Yang, Rui Han, Lu Wang, **aopeng Luo… in Cell Discovery (2023)

Article

Correction to: M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway

Hang Yin, Lin Chen, Shiqi Piao, Yiru Wang, Zhange Li… in Cell Death & Differentiation (2023)

Article

AXDND1, a novel testis-enriched gene, is required for spermiogenesis and male fertility

Spermiogenesis is a complex process depending on the sophisticated coordination of a myriad of testis-enriched gene regulations. The regulatory pathways that coordinate this process are not well understood, an...

Qian Ma, Congcong Cao, Changshui Zhuang, **aomin Luo, **aofeng Li… in Cell Death Discovery (2021)

Article

NLRP3 associated with chronic kidney disease progression after ischemia/reperfusion-induced acute kidney injury

Nod-like receptor protein 3 (NLRP3), as an inflammatory regulator, has been implicated in acute kidney injury (AKI). Failed recovery after AKI can lead to chronic kidney disease (CKD). However, the role of NLR...

Zhihuang Zheng, Kexin Xu, Chuanlei Li, Chenyang Qi, Yili Fang… in Cell Death Discovery (2021)

Article

Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation

Tuberous sclerosis complex (TSC) is characterized by hamartomatous lesions in multiple organs, with most patients develo** polycystic kidney disease and leading to a decline of renal function. TSC is caused ...

Yili Fang, Fang Li, Chenyang Qi, **ng Mao, Feng Wang, Zhonghua Zhao… in Cell Death Discovery (2020)

Article

Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection

Pulmonary edema is a fatal complication of EV71-associated hand, foot, and mouth disease (HFMD). The pathogenesis of EV71-induced pulmonary edema remains largely unclear. In this study, we aimed to explore the...

Nan Wang, **aofan Yang, Jiandong Sun, Zhixiao Sun, Qiyun Ma… in Cell Death Discovery (2019)

Article

Identification of small non-coding RNAs as sperm quality biomarkers for in vitro fertilization

Minmin Hua, Wei Liu, Ying Chen, Fengjuan Zhang, Beiying Xu, Suying Liu… in Cell Discovery (2019)

Article

Author Correction: CRISPR–Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development

In Fig. 2a of this Technical Report originally published, the authors inadvertently used the same set of images for the 4B2N1 and 4B2N3 cells when preparing the figure. The three images (bright field, Oct4-EGF...

Qing Li, Yan**g Li, Suming Yang, Shuo Huang, Meng Yan, Yifu Ding… in Nature Cell Biology (2019)