576 Result(s)

Article

Nuclear pseudogenes of mitochondrial DNA as a variable part of the human genome

Novel pseudogenes homologous to the mitochondrial (mt) 16S rRNA gene were detected via different approaches. Eight pseudogenes were sequenced. Copy number polymorphism of the mtDNA pseudogenes was observed amo...

** Duo YUAN, ** **u SHI, Guang Xun MENG, Li Guo AN, Geng ** HU in Cell Research (1999)

Article

Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocelular carcinoma

Using a combination of hybridization of PAC to a cDNA library and RACE technique, we isolated a novel cDNA, designated as C17orf25 (Chromosome 17 open reading frame 25, previously named it HC71A), from the del...

Wen **n QIN, Da Fang WAN, Fen Yong SUN, ** ** ZHANG, Li Wei HAN… in Cell Research (2001)

Article

Isolation of a choline monooxygenase cDNA clone from Amaranthus tricolor and its expressions under stress conditions

Plants synthesize the osmoprotectant glycine betaine (GB) via choline→ betaine aldehyde→glycine betaine¹. Two enzymes are involved in the pathway, choline monooxygenase (CMO) and betaine aldehyde dehydrogenase (B...

Yu Ling MENG, Yu Mei WANG, Da Bing ZHANG, Naosuke NII in Cell Research (2001)

Article

The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells

AIM The existence and properties of alpha-fetoprotein (AFP) receptor on the surface of NIH 3T3 cells and the effects of AFP on cellular signal transduction pathway were investigated. METHODS The effect of AFP ...

Meng Sen LI, ** Feng LI, Fei Yi YANG, Shi Peng HE, Guo Guang DU, Gang LI in Cell Research (2002)

Article

A novel link between the proteasome pathway and the signal transduction pathway of the Bone Morphogenetic Proteins (BMPs)

The intracellular signaling events of the Bone Morphogenetic Proteins (BMPs) involve the R-Smad family members Smad1, Smad5, Smad8 and the Co-Smad, Smad4. Smads are currently considered to be DNA-binding trans...

Yin Lin, Jennifer Martin, Cornelia Gruendler, Jennifer Farley… in BMC Cell Biology (2002)

Article

Negative regulation of TGF-β signaling in development

The TGF-β superfamily members have important roles in controlling patterning and tissue formation in both invertebrates and vertebrates. Two types of signal transducers, receptors and Smads, mediate the signal...

Ye Guang CHEN, An Ming MENG in Cell Research (2004)

Article

A novel in vitro system for gamete fusion in maize

Various systems by using electric pulse, calcium, or polyethylene glycol have been developed in the past decade for the in vitro fusion of plant gametes. These in vitro systems provide a new way to study the fert...

**ong Bo PENG, Meng **ang SUN, Hong Yuan YANG in Cell Research (2005)

Article

Induction of the LRP16 gene by estrogen promotes the invasive growth of Ishikawa human endometrial cancer cells through the downregulation of E-cadherin

LRP16 was previously identified as an estrogen-induced gene in breast cancer cells. The responsiveness of LRP16 to estrogen and its functional effects in endometrial cancer (EC) cells are still unclear. Here, we ...

Yuan Guang Meng, Wei Dong Han, Ya Li Zhao, Ke Huang, Yi Ling Si… in Cell Research (2007)

Article

Oncoprotein p28^GANK binds to RelA and retains NF-κB in the cytoplasm through nuclear export

p28^GANK (also known as PSMD10, p28 and gankyrin) is an ankyrin repeat anti-apoptotic oncoprotein that is commonly overexpressed in hepatocellular carcinomas and increases the degradation of p53 and Rb. NF-κB (nuc...

Yao Chen, Hong Hai Li, **g Fu, Xue Feng Wang, Yi Bin Ren, Li Wei Dong… in Cell Research (2007)

Article

The Arabidopsis MutS homolog AtMSH5 is required for normal meiosis

MSH5, a member of the MutS homolog DNA mismatch repair protein family, has been shown to be required for proper homologous chromosome recombination in diverse organisms such as mouse, budding yeast and Caenorhabd...

**aoduo Lu, **aolin Liu, Lizhe An, Wei Zhang, Jian Sun, Huijuan Pei… in Cell Research (2008)

Article

An EAL domain protein and cyclic AMP contribute to the interaction between the two quorum sensing systems in Escherichia coli

Quorum sensing (QS) is a bacterial cell-cell communication process by which bacteria communicate using extracellular signals called autoinducers. Two QS systems have been identified in Escherichia coli K-12, incl...

**anxuan Zhou, **aoming Meng, Baolin Sun in Cell Research (2008)

Article

RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer

Protein ubiquitination by E3 ubiquitin ligases plays an important role in cancer development. In this study, we provide experimental evidence that a RING-finger-containing protein RNF13 is an ER/Golgi membrane...

Qiang Zhang, Yunxiao Meng, Lei Zhang, Jie Chen, Dahai Zhu in Cell Research (2009)

Article

Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells

Human pluripotent stem cells represent a potentially unlimited source of functional pancreatic endocrine lineage cells. Here we report a highly efficient approach to induce human embryonic stem (ES) cells and ...

Donghui Zhang, Wei Jiang, Meng Liu, **n Sui, **aolei Yin, Song Chen… in Cell Research (2009)

Article

The TAK1-JNK cascade is required for IRF3 function in the innate immune response

Interferon regulatory factor (IRF)3 is critical for the transcriptional induction of chemokines and cytokines during viral or bacterial invasion. The kinases Tank binding kinase (TBK)1 and Ikappa B kinase (IKK...

Bianhong Zhang, Meng Li, Liang Chen, Kai Yang, Yufei Shan, Lianhui Zhu… in Cell Research (2009)

Article

Ag nanoparticles sensitize IR-induced killing of cancer cells

Ruizhi Xu, Jun Ma, **nchen Sun, Zhong** Chen, **aoli Jiang, Zhirui Guo… in Cell Research (2009)

Article

Erratum: Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans

Nature Cell Biol. 11, 934–942 (2009) In the version of this article initially published online and in print, the labelling of Fig 1e was incorrect. The correct version of this figure is shown below. This error...

Carolyn M. Phillips, **angdong Meng, Lei Zhang… in Nature Cell Biology (2009)

Article

Keratin 18 attenuates estrogen receptor α-mediated signaling by sequestering LRP16 in cytoplasm

Oncogenesis in breast cancer is often associated with excess estrogen receptor α(ERα) activation and overexpression of its coactivators. LRP16 is both an ERα target gene and an ERα coactivator, and plays a cru...

Yuanguang Meng, Zhiqiang Wu, **aoyun Yin, Yali Zhao, Meixia Chen… in BMC Cell Biology (2009)

Article

Ubiquitin B: an essential mediator of trichostatin A-induced tumor-selective killing in human cancer cells

Although histone deacetylase inhibitors (HDACis) are emerging as a new class of anticancer agents, the mechanism of tumor-selective killing by HDACi is not well understood. We used suppression of mortality by ...

P Wu, Y Tian, G Chen, B Wang, L Gui, L **, X Ma, Y Fang… in Cell Death & Differentiation (2010)

Article

Nuclear entry of active caspase-3 is facilitated by its p3-recognition-based specific cleavage activity

As a critical apoptosis executioner, caspase-3 becomes activated and then enters into the nucleus to exert its function. However, the molecular mechanism of this nuclear entry of active caspase-3 is still unkn...

Min Luo, Zhiyong Lu, He Sun, Kehu Yuan, Quancang Zhang, Sha Meng… in Cell Research (2010)

Article

Sua5p is required for telomere recombination in Saccharomyces cerevisiae

Fei-Long Meng, **ao-Fen Chen, Yan Hu, Hong-Bo Tang, Wei Dang, **-Qiu Zhou in Cell Research (2010)