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Article
Open AccessRole of hepatitis B surface antigen in the development of hepatocellular carcinoma: regulation of lymphoid enhancer-binding factor 1
There are around 350 million of hepatitis B surface antigen (HBsAg) carriers worldwide, and among them, high risk of develo** hepatocellular carcinoma (HCC) has been identified by epidemiological studies. To...
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Article
pp5644 Interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1
The human novel gene pp5644 (GeneBank Accession No. AF289559) coding for 124 amino acids was recently cloned. Overexpression of pp5644 in Hela cells significantly inhibited the growth and colony formation. The pp...
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Article
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120
CT120, a novel membrane-associated gene implicated in lung carcinogenesis, was previously identified from chromosome 17p13.3 locus, a hot mutation spot involved in human malignancies. In the present study, we ...
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Article
Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein
We have identified IC53-2, a human homologue of the rat C53 gene from a human placenta cDNA library (GeneBank Accession No.AF217982). IC53-2 can bind to the CDK5 activator p35 by in vitro association assay. IC...
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Article
The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1 (RNMTL1) gene, a newly discovered 17p13.3 gene
The human RNA methyltransferase like 1 gene (RNMTL1) is one of thirteen newly discovered genes within a 116 Kb segment of the chromosome 17p13.3 that suffers from a high frequent loss of heterozygosity in huma...
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Article
Cloning and characterization of a novel gene (C17orf25) from the deletion region on chromosome 17p13.3 in hepatocelular carcinoma
Using a combination of hybridization of PAC to a cDNA library and RACE technique, we isolated a novel cDNA, designated as C17orf25 (Chromosome 17 open reading frame 25, previously named it HC71A), from the del...
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Article
A novel gene delivery system targeting cells expressing VEGF receptors
Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or pro...
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Article
Differential expression of a cDNA clone in human liver versus hepatic cancer highly homologous to aryl-dialkylphosphatase
We applied the technique of mRNA differential display to normal liver tissue and hepatoma cell line Hep3B. One of the isolated cDNA clones was expressed in human normal liver tissue but not in the human hepato...
