4,026 Result(s)
-
Article
Open AccessCarbon-ion radiotherapy alone vs. standard dose photon radiation with carbon-ion radiotherapy boost for high-grade gliomas: a retrospective study
This study aimed to compare the survival outcome and side effects in patients with primary high-grade glioma (HGG) who received carbon ion radiotherapy (CIRT) alone or as a boost strategy after photon radiatio...
-
Article
Open AccessPegylated recombinant human granulocyte colony-stimulating factor for primary prophylaxis of neutropenia in patients with cervical cancer receiving concurrent chemoradiotherapy: a prospective study
This study aimed to investigate the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) for primary prophylaxis of neutropenia in patients with cervical cance...
-
Article
Open AccessNomogram for predicting the probability of rectal anastomotic re-leakage after stoma closure: a retrospective study
In this study, we aimed to identify the risk factors in patients with rectal anastomotic re-leakage and develop a prediction model to predict the probability of rectal anastomotic re-leakage after stoma closure.
-
Article
Open AccessAn analysis of the role of GAB2 in pan-cancer from a multidimensional perspective
To explore the role of GAB2 in pan-cancer based on bioinformatics analysis.
-
Article
Open AccesseHSP90α in front-line therapy in EGFR exon 19 deletion and 21 Leu858Arg mutations in advanced lung adenocarcinoma
Extracellular heat shock protein 90 AA1(eHSP90α) is intricately linked to tumor progression and prognosis. This study aimed to investigate the difference in the value of eHSP90α in post-treatment response asse...
-
Article
Open AccessCorrection: Apatinib combined with temozolomide in diffuse midline glioma: a novel and effective therapy
-
Article
Open AccessSurvival of advanced/recurrent gastrointestinal stromal tumors treated with tyrosine kinase inhibitors in Taiwan: a nationwide registry study
Most gastrointestinal stromal tumors (GISTs) harbor c-KIT or PDGFRA mutations. Administration of tyrosine kinase inhibitors (TKIs) has significantly improved the survival of patients with GISTs. We aimed to evalu...
-
Article
Open AccessNovel associations between MTDH gene polymorphisms and invasive ductal breast cancer: a case–control study
To reveal the contributing effects of MTDH gene SNPs in the risk of invasive ductal breast cancer (IDC).
-
Article
Open AccessInvestigation of prognostic values of immune infiltration and LGMN expression in the microenvironment of osteosarcoma
Osteosarcoma (OS), the most common primary malignant bone tumor, predominantly affects children and young adults and is characterized by high invasiveness and poor prognosis. Despite therapeutic advancements, ...
-
Article
Open AccessDevelopment and validation of a neoadjuvant chemotherapy pathological complete remission model based on Reg IV expression in breast cancer tissues: a clinical retrospective study
To develop and authenticate a neoadjuvant chemotherapy (NACT) pathological complete remission (pCR) model based on the expression of Reg IV within breast cancer tissues with the objective to provide clinical g...
-
Article
Breast-conserving surgery versus modified radical mastectomy in T1-2N3M0 stage breast cancer: a propensity score matching analysis
Breast-conserving surgery (BCS) plus radiotherapy and mastectomy exhibit highly comparable prognoses for early-stage breast cancer; however, the safety of BCS for T1-2N3M0 breast cancer remains unclear. This s...
-
Article
Open AccessSelective anti-tumor activity of glutathione-responsive abasic site trap** agent in anaplastic thyroid carcinoma
Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive thyroid cancer with poor prognosis. Killing cancer cells by inducing DNA damage or blockage of DNA repair is a promising strategy for chemothe...
-
Article
Open AccessPrognostic and clinicopathological significance of tertiary lymphoid structure in non-small cell lung cancer: a systematic review and meta-analysis
Non-small cell lung cancer (NSCLC) is the primary reason for cancer-related deaths globally. Tertiary lymphoid structure (TLS) is an organized collection of immune cells acquired in non-physiological, non-lymp...
-
Article
Open AccessKK-LC-1, a biomarker for prognosis of immunotherapy for primary liver cancer
There is mounting evidence that patients with liver cancer can benefit from Immune checkpoint inhibitors. However, due to the high cost and low efficacy, we aimed to explore new biomarkers for predicting the e...
-
Article
Open AccessEstablishment and characterization of a novel multidrug-resistant pancreatic ductal adenocarcinoma cell line, PDAC-X1
Drug resistance remains a significant challenge in the treatment of pancreatic cancer. The development of drug-resistant cell lines is crucial to understanding the underlying mechanisms of resistance and devel...
-
Article
Open AccessEstablishment of a nomogram to predict the overall survival of patients with collecting duct renal cell carcinoma
Collecting duct carcinoma (CDC) is a rare histological type of renal cell carcinoma that lacks a prognostic prediction model. In this study, we developed a nomogram to predict the prognosis of CDC patients.
-
Article
Antibody–drug conjugates in gastric cancer: from molecular landscape to clinical strategies
Antibody–drug conjugates (ADCs) represent a crucial component of targeted therapies in gastric cancer, potentially altering traditional treatment paradigms. Many ADCs have entered rigorous clinical trials base...
-
Article
Open AccessPANoptosis-based molecular subtype and prognostic model predict survival and immune landscape in esophageal cancer
To establish a prognostic model to predict the survival of patients with esophageal cancer (EC).
-
Article
Open AccessPromoter profiles in plasma CfDNA exhibits a potential utility of predicting the efficacy of neoadjuvant chemotherapy in breast cancer patients
Gene expression profiles in breast tissue biopsies contain information related to chemotherapy efficacy. The promoter profiles in cell-free DNA (cfDNA) carrying gene expression information of the original tiss...
-
Article
Open AccessAndrogen receptor-mediated pharmacogenomic expression quantitative trait loci: implications for breast cancer response to AR-targeting therapy
Endocrine therapy is the most important treatment modality of breast cancer patients whose tumors express the estrogen receptor α (ERα). The androgen receptor (AR) is also expressed in the vast majority (80–90...
