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Article
Open AccessAn analysis of the role of GAB2 in pan-cancer from a multidimensional perspective
To explore the role of GAB2 in pan-cancer based on bioinformatics analysis.
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Article
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates
α-Synuclein (α-Syn) aggregation is closely associated with Parkinson’s disease neuropathology. Physiologically, α-Syn promotes synaptic vesicle (SV) clustering and soluble N-ethylmaleimide-sensitive factor attach...
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Article
Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging
Autophagy is a lysosome-dependent degradation pathway essential for cellular homeostasis, which decreases with age. However, it is unclear how aging induces autophagy decline. Here we show the role of protein S-p...
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Article
Crustal Electrical Structure of the Wuwei Basin, Lower Yangtze Region of China, and Its Geological Implications
The Wuwei Basin is one of the most important oil- and gas-bearing basins in the Meso-Cenozoic basin groups in the Lower Yangtze River region. It has great shale gas resource prospects. The formation mechanism ...
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Article
Tunable multicolor luminescence in vanadates from yttrium to indium with enhanced luminous efficiency and stability for its application in WLEDs and indoor photovoltaics
The preparation of high-efficiency phosphor is the key to the construction of white light-emitting diode (WLED) devices and their application in indoor photovoltaics. Compared with YVO4, InVO4 is not suitable as ...
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Article
Tailored ZnF2/ZnS-rich interphase for reversible aqueous Zn batteries
The urgent need for highly safe and sustainable large-scale energy storage systems for residential buildings has led to research into aqueous zinc ion batteries. However, when zinc is used in aqueous zinc ion ...
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Article
Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies
TDP-43 proteinopathy is linked to neurodegenerative diseases that feature synaptic loss in the cortex and hippocampus, although it remains unclear how TDP-43 regulates mature synapses. We report that, in adult...
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Article
Open AccessBenchmarking commonly used software suites and analysis workflows for DIA proteomics and phosphoproteomics
A plethora of software suites and multiple classes of spectral libraries have been developed to enhance the depth and robustness of data-independent acquisition (DIA) data processing. However, how the combinat...
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Open AccessGeneric amyloid fibrillation of TMEM106B in patient with Parkinson’s disease dementia and normal elders
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Open AccessThe hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type α-synuclein
α-Synuclein (α-Syn) can form different fibril strains with distinct polymorphs and neuropathologies, which is associated with the clinicopathological variability in synucleinopathies. How different α-syn fibri...
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Article
Open AccessQuantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production
Necroptosis is a form of regulated necrotic cell death that promotes inflammation. In cells undergoing necroptosis, activated RIPK1 kinase mediates the formation of RIPK1/RIPK3/MLKL complex to promote MLKL oli...
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Article
Open AccessLow level laser therapy promotes bone regeneration by coupling angiogenesis and osteogenesis
Bone tissue engineering is a new concept bringing hope for the repair of large bone defects, which remains a major clinical challenge. The formation of vascularized bone is key for bone tissue engineering. Gro...
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Open AccessA necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression
Mixed-lineage kinase domain-like protein (MLKL) is known as the terminal executor of necroptosis. However, its function outside of necroptosis is still not clear. Herein, we demonstrate that MLKL promotes vasc...
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Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation
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Open AccessUbiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
The long-lived proteome constitutes a pool of exceptionally stable proteins with limited turnover. Previous studies on ubiquitin-mediated protein degradation primarily focused on relatively short-lived protein...
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Article
PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins
Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegen...
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Erratum: A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1
Nat. Immunol.; doi:10.1038/ni.3463; corrected online 20 May 2016 In the version of this article initially published online, in the keys in Figure 3i–l, the Icos-specific shRNA was incorrectly designated 'sh/co...
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A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1
Signaling via the inducible costimulator ICOS drives the stepwise development of follicular helper T cells. Kong and colleagues describe an ICOS–kinase TBK1 signaling pathway that specifies the commitment of t...
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Protein kinase C-η controls CTLA-4–mediated regulatory T cell function
Signaling events at the Treg cell immune synapse remain unknown. Altman and colleagues show that a CTLA-4–PKC-η signaling axis is required for contact-dependent suppression by Treg cells.
