11 Result(s)

Article

Robust Sub-nanomolar Library Preparation for High Throughput Next Generation Sequencing

Current library preparation protocols for Illumina HiSeq and MiSeq DNA sequencers require ≥2 nM initial library for subsequent loading of denatured cDNA onto flow cells. Such amounts are not always attainable ...

Wells W. Wu, Je-Nie Phue, Chun-Ting Lee, Changyi Lin, Lai Xu, Rong Wang… in BMC Genomics (2018)

Article

A gastric cancer LncRNAs model for MSI and survival prediction based on support vector machine

Recent studies have shown that long non-coding RNAs (lncRNAs) play a crucial role in the induction of cancer through epigenetic regulation, transcriptional regulation, post-transcriptional regulation and other...

Tao Chen, Cangui Zhang, Yingqiao Liu, Yuyun Zhao, Dingyi Lin, Yanfeng Hu… in BMC Genomics (2019)

Article

PhySpeTree: an automated pipeline for reconstructing phylogenetic species trees

Phylogenetic species trees are widely used in inferring evolutionary relationships. Existing software and algorithms mainly focus on phylogenetic inference. However, less attention has been paid to intermediat...

Yang Fang, Chengcheng Liu, Jiangyi Lin, Xufeng Li… in BMC Evolutionary Biology (2019)

Article

Preclinical studies using cisplatin/carboplatin to restore the Enzalutamide sensitivity via degrading the androgen receptor splicing variant 7 (ARv7) to further suppress Enzalutamide resistant prostate cancer

The FDA-approved anti-androgen Enzalutamide (Enz) has been used successfully as the last line therapy to extend castration-resistant prostate cancer (CRPC) patients’ survival by an extra 4.8 months. However, C...

Fu-Ju Chou, ChangYi Lin, Hao Tian, WanYing Lin, Bosen You… in Cell Death & Disease (2020)

Article

Comparison of the effects of introducing the CRISPR/Cas9 system by microinjection and electroporation into porcine embryos at different stages

Cytoplasmic microinjection and electroporation of the CRISPR/Cas9 system into zygotes are used for generating genetically modified pigs. However, these methods create mosaic mutations in embryos. In this study...

Quynh Anh Le, Fuminori Tanihara, Manita Wittayarat, Zhao Namula… in BMC Research Notes (2021)

Article

Timing and duration of lipofection-mediated CRISPR/Cas9 delivery into porcine zygotes affect gene-editing events

Lipofection-mediated introduction of the CRISPR/Cas9 system in porcine zygotes provides a simple method for gene editing, without requiring micromanipulation. However, the gene editing efficiency is inadequate...

Qingyi Lin, Quynh Anh Le, Koki Takebayashi… in BMC Research Notes (2021)

Article

Circular RNA circPOSTN promotes neovascularization by regulating miR-219a-2-3p/STC1 axis and stimulating the secretion of VEGFA in glioblastoma

Glioblastoma (GBM), the most malignant type of astrocytic tumor, is one of the deadliest cancers prevalent in adults. Along with tumor growth, patients with GBM generally suffer from extensive cerebral edema a...

Niya Long, Xu Xu, Hongyi Lin, Ying Lv, Shenghui Zou, Han Cao… in Cell Death Discovery (2022)

Article

Genome-wide identification and immune response analysis of mitogen-activated protein kinase cascades in tea geometrid, Ectropis grisescens Warren (Geometridae, Lepidoptera)

Tea geometrid Ectropis grisescens (Geometridae: Lepidoptera), is one of the most destructive defoliators in tea plantations in China. The MAPK cascade is known to be an evolutionarily conserved signaling module, ...

**aozhu Wu, Chenghua Zhou, **aofang Li, **gyi Lin… in BMC Genomics (2023)

Article

Correction to: Genome-wide identifcation and immune response analysis of mitogen-activated protein kinase cascades in tea geometrid, Ectropis grisescens Warren (Geometridae, Lepidoptera)

**aozhu Wu, Chenghua Zhou, **aofang Li, **gyi Lin… in BMC Genomics (2023)

Article

The OGT–c-Myc–PDK2 axis rewires the TCA cycle and promotes colorectal tumor growth

Deregulated glucose metabolism termed the “Warburg effect” is a fundamental feature of cancers, including the colorectal cancer. This is typically characterized with an increased rate of glycolysis, and a conc...

Huijuan Wang, Jie Sun, Haofan Sun, Yifei Wang, Bingyi Lin… in Cell Death & Differentiation (2024)