81 Result(s)

Article

New progress in roles of TGF-β signaling crosstalks in cellular functions, immunity and diseases

The family of secreted dimeric proteins known as the Transforming Growth Factor-β (TGF-β) family plays a critical role in facilitating intercellular communication within multicellular animals. A recent symposi...

Shuchen Gu, Rik Derynck, Ye-Guang Chen, **n-Hua Feng in Cell Regeneration (2024)

Article

Unveiling new horizons in heart research: the promise of multi-chamber cardiac organoids

Human cardiac and other organoids have recently emerged as a groundbreaking tool for advancing our understanding the developmental biology of human organs. A recent paper from Sasha Mendjan’s laboratory publis...

Junjie Hou, Ye-Guang Chen, **g-Wei **ong in Cell Regeneration (2024)

Article

Re-expression of epigenetically silenced PTPRR by histone acetylation sensitizes RAS-mutant lung adenocarcinoma to SHP2 inhibition

Silenced protein tyrosine phosphatase receptor type R (PTPRR) participates in mitogen-activated protein kinase (MAPK) signaling cascades during the genesis and development of tumors. Rat sarcoma virus (Ras) genes...

Tingting Du, **aowen Hu, Zhenyan Hou, Weida Wang… in Cellular and Molecular Life Sciences (2024)

Article

Correction: The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling

Siting Wei, Meng Li, Wanlu Song, Jiaye Liu, Shicheng Yu, Yalong Wang… in Cell Regeneration (2023)

Article

USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target

An essential protein regulatory system in cells is the ubiquitin-proteasome pathway. The substrate is modified by the ubiquitin ligase system (E1-E2-E3) in this pathway, which is a dynamic protein bidirectiona...

Shuang Li, Yang Song, Kexin Wang, Guoxiang Liu, **aolei Dong… in Cell Death Discovery (2023)

Article

The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling

Paracrine signals play pivotal roles in organ homeostasis. Mesenchymal stromal cells (MSCs) play a key role in regulating epithelium homeostasis in the intestine while their paracrine effects are poorly charac...

Siting Wei, Meng Li, Wanlu Song, Jiaye Liu, Shicheng Yu, Yalong Wang… in Cell Regeneration (2023)

Article

Cross-species single-cell transcriptomic analysis of animal gastric antrum reveals intense porcine mucosal immunity

As an important part of the stomach, gastric antrum secretes gastrin which can regulate acid secretion and gastric emptying. Although most cell types in the gastric antrum are identified, the comparison of cel...

**aodan Wang, Fan Hong, Haonan Li, Yalong Wang, Mengxian Zhang… in Cell Regeneration (2023)

Article

Standard: Human intestinal cancer organoids

Intestinal cancer is one of the most frequent and lethal types of cancer. Modeling intestinal cancer using organoids has emerged in the last decade. Human intestinal cancer organoids are physiologically releva...

Hanqing Lin, Yalong Wang, Chunyan Cheng, Yuxin Qian, Jie Hao… in Cell Regeneration (2023)

Article

RNF128 regulates neutrophil infiltration and myeloperoxidase functions to prevent acute lung injury

Acute lung injury (ALI) is characterised by severe pulmonary inflammation, alveolar-capillary barrier disruption, and pulmonary oedema. Therefore, establishing effective therapeutic targets for ALI prevention ...

Pei-Yao Liu, Chih-Yuan Chen, Yu-Lung Lin, Chien-Ming Lin… in Cell Death & Disease (2023)

Article

Standard: Human intestinal organoids

Organoids have attracted great interest for disease modelling, drug discovery and development, and tissue growth and homeostasis investigations. However, lack of standards for quality control has become a prom...

Yalong Wang, Hanqing Lin, Lianzheng Zhao, Fan Hong, Jie Hao… in Cell Regeneration (2023)

Article

Combination treatment with FAAH inhibitors/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K-AKT signaling pathway

Ferroptosis, a nonapoptotic form of programmed cell death characterized by significant iron-dependent peroxidation of phospholipids, is regulated by cellular metabolism, redox homeostasis, and various cancer-r...

Junfeng Hao, Qiguang Chen, Yongmin Feng, Qiyu Jiang, Huiwei Sun… in Cell Death & Disease (2023)

Article

PLK1 inhibition promotes apoptosis and DNA damage in glioma stem cells by regulating the nuclear translocation of YBX1

Glioma stem cells (GSCs) are the important cause of tumorigenesis, recurrence, and chemo(radio)resistance in glioma. Targeting GSCs helps improve the outcomes of glioma treatment. Polo-like kinase 1 (PLK1) is ...

Xuetao Li, Guangliang Chen, Bin Liu, Zhennan Tao, Yue Wu, Kai Zhang… in Cell Death Discovery (2023)

Article

Development of a 32-gene signature using machine learning for accurate prediction of inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by multiple genetic and environmental factors. Numerous genes are implicated in the etiology of IBD, but the diagnosis of IBD is chal...

Shicheng Yu, Mengxian Zhang, Zhaofeng Ye, Yalong Wang, Xu Wang… in Cell Regeneration (2023)

Article

Intestinal cellular heterogeneity and disease development revealed by single-cell technology

The intestinal epithelium is responsible for food digestion and nutrient absorption and plays a critical role in hormone secretion, microorganism defense, and immune response. These functions depend on the int...

Yalong Wang, Wanlu Song, Shicheng Yu, Yuan Liu, Ye-Guang Chen in Cell Regeneration (2022)

Article

Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop

Triple-negative breast cancer (TNBC), an aggressive histological subtype of breast cancer, exhibits a high risk of early recurrence rate and a poor prognosis, and it is primarily associated with the abundance ...

Yingying Shen, Qingyun Zhu, Maoyu **ao, Liyang Yin, Wenjie Feng… in Cell Death & Disease (2022)

Article

DDB1 maintains intestinal homeostasis by preventing cell cycle arrest

Lianzheng Zhao, Hongwei Liao, **aodan Wang, Ye-Guang Chen in Cell Regeneration (2022)