208 Result(s)
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**guang Chen
Life Sciences
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Article
Molecular and physiological evidence of HvCaLB1 regulates calcium homeostasis and salt tolerance in Barley
The loss of crop productivity due to soil salinity is an increasing threat to agriculture worldwide. Calcium (Ca2+) plays vital roles in salt-responsive signaling through the perception of various calcium-binding...
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Open AccessNew progress in roles of TGF-β signaling crosstalks in cellular functions, immunity and diseases
The family of secreted dimeric proteins known as the Transforming Growth Factor-β (TGF-β) family plays a critical role in facilitating intercellular communication within multicellular animals. A recent symposi...
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Open AccessOverexpression of OsNAR2.1 by OsNAR2.1 promoter increases drought resistance by increasing the expression of OsPLDα1 in rice
pOsNAR2.1:OsNAR2.1 expression could significantly increase nitrogen uptake efficiency and grain yield of rice.
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Open AccessUnveiling new horizons in heart research: the promise of multi-chamber cardiac organoids
Human cardiac and other organoids have recently emerged as a groundbreaking tool for advancing our understanding the developmental biology of human organs. A recent paper from Sasha Mendjan’s laboratory publis...
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TMED10-mediated unconventional secretion of IL-33 regulates intestinal epithelium differentiation and homeostasis
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The PpMYB75-PpDFR module reveals the difference between ‘SR’ and its bud variant ‘RMHC’ in peach red flesh
‘Red Meat Honey Crisp (RMHC)’ has been widely cultivated by growers in recent years due to its early maturity, and red meat type characteristics. As a bud variant of ‘Super Red (SR)’ peach, red flesh is the mo...
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Re-expression of epigenetically silenced PTPRR by histone acetylation sensitizes RAS-mutant lung adenocarcinoma to SHP2 inhibition
Silenced protein tyrosine phosphatase receptor type R (PTPRR) participates in mitogen-activated protein kinase (MAPK) signaling cascades during the genesis and development of tumors. Rat sarcoma virus (Ras) genes...
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HPF1 regulates tendon stem/progenitor cell senescence and tendon repair via PARP1-mediated poly-ADP ribosylation of HuR
Tendon stem/progenitor cells (TSPCs) play a vital role in tendon repair, regeneration and homeostasis. However, the specific mechanism of TSPCs aging is still unclear.
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Evaluation of polyphenols content and antioxidant ability of commercial herbal beer
Herbs are rich in polyphenols compounds that are often added to beer to boost its antioxidant ability. To prove herbs can efficiently enhance the antioxidant ability of beer, the total polyphenols and flavonoi...
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Article
Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals
Liver fibrosis is an aberrant wound healing response to tissue injury characterized by excessive extracellular matrix deposition and loss of normal liver architecture. Hepatic stellate cells (HSCs) activation ...
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Open AccessAllene oxide synthase 1 contributes to limiting grain arsenic accumulation and seedling detoxification in rice
Arsenic (As) is a cancerogenic metalloid ubiquitously distributed in the environment, which can be easily accumulated in food crops like rice. Jasmonic acid (JA) and its derivatives play critical roles in plan...
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Open AccessHydrangea paniculata coumarins attenuate experimental membranous nephritis by bidirectional interactions with the gut microbiota
Coumarins isolated from Hydrangea paniculata (HP) had a renal protective effect in experimental membranous nephritis (MN), but the mechanisms are not clear. Currently, we investigate whether the modulation of gut...
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Classification models for predicting the bioactivity of pan-TRK inhibitors and SAR analysis
Tropomyosin receptor kinases (TRKs) are important broad-spectrum anticancer targets. The oncogenic rearrangement of the NTRK gene disrupts the extracellular structural domain and epitopes for therapeutic antib...
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Insecticidal effect of green walnut husks and its active basis digesting targeting to insect phenoloxidase using UPLC-Q-TOF-MS coupled with PLS analysis
The immature fruit exocarp of Juglans mandshurica Maxim., also called “green walnut husks” (GWH), are usually discarded as food waste. Although GWH has been used as folk insecticides for many years, its bioactive...
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Open AccessCorrection: The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling
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Open AccessThe dynamics of deltamethrin resistance evolution in Aedes albopictus has an impact on fitness and dengue virus type-2 vectorial capacity
Worldwide invasion and expansion of Aedes albopictus, an important vector of dengue, chikungunya, and Zika viruses, has become a serious concern in global public health. Chemical insecticides are the primary mean...
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Open AccessUSP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target
An essential protein regulatory system in cells is the ubiquitin-proteasome pathway. The substrate is modified by the ubiquitin ligase system (E1-E2-E3) in this pathway, which is a dynamic protein bidirectiona...
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Open AccessThe cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling
Paracrine signals play pivotal roles in organ homeostasis. Mesenchymal stromal cells (MSCs) play a key role in regulating epithelium homeostasis in the intestine while their paracrine effects are poorly charac...
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CircUSP48 promotes malignant behavior by regulating CYR61 via miR-365 in osteosarcoma
Even though circular RNAs (circRNAs), a class of non-coding endogenous RNA, play a crucial role in the progression of osteosarcoma (OS), the specific function of hsa_circ_0000028 (circUSP48) remains unclear. T...
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Open AccessA stromal lineage maintains crypt structure and villus homeostasis in the intestinal stem cell niche
The nutrient-absorbing villi of small intestines are renewed and repaired by intestinal stem cells (ISCs), which reside in a well-organized crypt structure. Genetic studies have shown that Wnt molecules secret...
