16 Result(s)
within
**ghai Li
Microbiology
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Article
Putative role of uncoupling proteins in mitochondria-nucleus communications and DNA damage response
Mitochondria-nucleus communications and DNA damage response (DDR) play roles in cellular stress and closely associate with a range of diseases. Mitochondrial uncoupling proteins (UCPs) are capable of uncouplin...
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Open AccessAllogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice
Mesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment of a range of diseases or medical conditions. Autologous or allogeneic MSCs obtained from self or donors have their own...
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Open AccessAnalysis of spleen histopathology, splenocyte composition and haematological parameters in four strains of mice infected with Plasmodium berghei K173
Malaria is a fatal disease that presents clinically as a continuum of symptoms and severity, which are determined by complex host-parasite interactions. Clearance of infection is believed to be accomplished by...
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Introduction of heterologous transcription factors and their target genes into Penicillium oxalicum leads to increased lignocellulolytic enzyme production
Genetic engineering of transcription factors is an efficient strategy to improve lignocellulolytic enzyme production in fungi. In this study, the xylanase transcriptional regulators of Trichoderma reesei (Xyr1) a...
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Article
Open AccessCow manure as a lignocellulosic substrate for fungal cellulase expression and bioethanol production
Conversion of various lignocellulosic materials into bioethanol is growing in demand but greatly depends on feedstock availability. Dairy cow manure is an agricultural waste widely distributed worldwide. This ...
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Large-scale cultivation of Spirulina in a floating horizontal photobioreactor without aeration or an agitation device
A low-cost floating photobioreactor (PBR) without the use of aeration and/or an agitation device, in which carbon was supplied in the form of bicarbonate and only wave energy was utilized for mixing, was devel...
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Development of Highly Efficient, Low-Cost Lignocellulolytic Enzyme Systems in a Penicillium: From Strain Screening to Systems Biology
Some Penicillium species have been reported to produce enzyme systems with good performances in lignocellulose degradation. Penicillium oxalicum (formerly classified as P. decumbens) strains, which produce more b...
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Open AccessCombining manipulation of transcription factors and overexpression of the target genes to enhance lignocellulolytic enzyme production in Penicillium oxalicum
Lignocellulolytic enzymes are the main enzymes to saccharify lignocellulose from renewable plant biomass in the bio-based economy. The production of these enzymes is transcriptionally regulated by multiple tra...
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Open AccessProduction of a high-efficiency cellulase complex via β-glucosidase engineering in Penicillium oxalicum
Trichoderma reesei is a widely used model cellulolytic fungus, supplying a highly effective cellulase production system. Recently, the biofuel industry discovered filamentous fungi fro...
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Open AccessRedesigning the regulatory pathway to enhance cellulase production in Penicillium oxalicum
In cellulolytic fungi, induction and repression mechanisms synchronously regulate the synthesis of cellulolytic enzymes for accurate responses to carbon sources in the environment. Many proteins, particularly ...
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Article
Cellodextrin transporters play important roles in cellulase induction in the cellulolytic fungus Penicillium oxalicum
Cellodextrin transporters (cellodextrin permeases) have been identified in fungi in recent years. However, the functions of these transporters in cellulose utilization and cellulase expression have not been we...
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Construction of engineered Arthrobacter simplex with improved performance for cortisone acetate biotransformation
Arthrobacter simplex 156 is a microorganism that is used for steroid drug biotransformation of cortisone acetate (CA) to prednisone acetate (PA). The enzyme 3-ketosteroid-△1-dehydrogenase encoded...
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Microbial diversity in the snow, a moraine lake and a stream in Himalayan glacier
The microbial diversity and abundance in surface snow at different altitudes (5300 and 5504 m above sea level), a moraine lake and a glacial stream in the Yala Glacier on the southern slope of the Himalayas we...
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Article
7-O-descarbamoyl-7-hydroxygeldanamycin, a minor component from the gdmN disruption mutant of Streptomyces hygroscopicus 17997
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Article
Identification and Characterization of a Novel Thymus Aging Related Protein Rwdd1
By using DDRT-PCR and EST segment ligation, a novel mouse thymus involution related gene Rwdd1 was identified. The reading frame encoded a protein of 243 amino acid residues which contained an RWD domain at the N...
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Article
A New Post-PKS Modification Process in the Carbamoyltransferase Gene Inactivation Strain of Streptomyces hygroscopicus 17997
Genetic manipulation of geldanamycin (GDM) producer Streptomyces species is a rational approach to understand biosynthesis processes and create new analogues. In this study, the carbamoyltransferase gene gdmN was...
