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Article
Open AccessScreening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin
Lovastatin has widespread applications thanks to its multiple pharmacological effects. Fermentation by filamentous fungi represents the major way of lovastatin production. However, the current lovastatin produ...
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Article
Open AccessEnhanced production of terrein in marine-derived Aspergillus terreus by refactoring both global and pathway-specific transcription factors
Terrein, a major secondary metabolite from Aspergillus terreus, shows great potentials in biomedical and agricultural applications. However, the low fermentation yield of terrein in wild A. terreus strains limits...
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Article
Development of versatile and efficient genetic tools for the marine-derived fungus Aspergillus terreus RA2905
Marine-derived Aspergillus terreus produces a variety of structurally novel secondary metabolites, most of which show unique biological activities. However, the lack of efficient genetic tools limits the discover...
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Article
Contribution of peroxisomal protein importer AflPex5 to development and pathogenesis in the fungus Aspergillus flavus
Peroxisomes are important organelles that have diverse metabolic functions and participate in the pathogenicity of fungal pathogens. Previous studies indicate that most functions of peroxisomes are dependent o...
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Article
Open AccessProduction of a high-efficiency cellulase complex via β-glucosidase engineering in Penicillium oxalicum
Trichoderma reesei is a widely used model cellulolytic fungus, supplying a highly effective cellulase production system. Recently, the biofuel industry discovered filamentous fungi fro...
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Article
Open AccessProteomic analysis of the biomass hydrolytic potentials of Penicillium oxalicum lignocellulolytic enzyme system
The mining of high-performance enzyme systems is necessary to develop industrial lignocellulose bioconversion. Large amounts of cellulases and hemicellulases can be produced by Penicillium oxalicum. Hence, the en...
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Article
Open AccessRedesigning the regulatory pathway to enhance cellulase production in Penicillium oxalicum
In cellulolytic fungi, induction and repression mechanisms synchronously regulate the synthesis of cellulolytic enzymes for accurate responses to carbon sources in the environment. Many proteins, particularly ...
