15 Result(s)

Article

Establishment of disulfidptosis-related LncRNA signature as biomarkers in colon adenocarcinoma

Metabolic reprogramming is a hallmark of cancer and plays a key role in precision oncology treatment. Long non-coding RNAs (lncRNAs) regulate cancer cell behavior, including metabolism. Disulfidptosis, a newly...

Hongfei Yao, Peng Liu, Linli Yao, **ao Li in Cancer Cell International (2024)

Article

A new prognostic model based on gamma-delta T cells for predicting the risk and aiding in the treatment of clear cell renal cell carcinoma

ccRCC is the prevailing form of RCC, accounting for the majority of cases. The formation of cancer and the body's ability to fight against tumors are strongly connected to Gamma delta (γδ) T cells.

Yaqian Wu, Mengfei Yao, Zonglong Wu, Lulin Ma, Cheng Liu in Discover Oncology (2024)

Article

Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis

Sympathetic innervation is essential for the development of functional beige fat that maintains body temperature and metabolic homeostasis, yet the molecular mechanisms controlling this innervation remain larg...

Xun Huang, **nmeng Li, Hongyu Shen, Yiheng Zhao, Zhao Zhou… in Nature Communications (2023)

Article

Genome instability-related LINC02577, LINC01133 and AC107464.2 are lncRNA prognostic markers correlated with immune microenvironment in pancreatic adenocarcinoma

Pancreatic adenocarcinoma (PAAD) is a leading cause of malignancy-related deaths worldwide, and the efficacy of immunotherapy on PAAD is limited. Studies report that long non-coding RNAs (lncRNAs) play an impo...

Yinjiang Zhang, Yao Wang, Xu He, Rongfei Yao, Lu Fan, Linyi Zhao, Binan Lu… in BMC Cancer (2023)

Article

The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis

Fibrosis disrupts adipose tissue (AT) homeostasis and exacerbates metabolic dysfunction upon chronic caloric excess. The molecular mechanisms linking adipocyte plasticity to AT fibrosis are largely unknown. He...

Hongyu Shen, Xun Huang, Yiheng Zhao, Dongmei Wu, Kaili Xue… in Nature Communications (2022)

Article

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Prostate cancer (PCa) is a malignant tumor that seriously threatens men’s health worldwide. Recently, stromal cells in the tumor microenvironment (TME) have been reported to contribute to the progression of PC...

Tianqi Wu, Wenfeng Wang, Guohai Shi, Mingang Hao, Yingying Wang… in Cell Death & Disease (2022)

Article

LncRNA RP11-89 facilitates tumorigenesis and ferroptosis resistance through PROM2-activated iron export by sponging miR-129-5p in bladder cancer

Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and development in bladder cancer. However, the underlying molecular mechanisms remain elusive. We previously identified a novel lncR...

Wenjie Luo, Jun Wang, Wenhao Xu, Chunguang Ma, Fangning Wan… in Cell Death & Disease (2021)

Article

Improved functionality of Ligilactobacillus salivarius Li01 in alleviating colonic inflammation by layer-by-layer microencapsulation

The low viability during gastrointestinal transit and poor mucoadhesion considerably limits the effectiveness of Ligilactobacillus salivarius Li01 (Li01) in regulating gut microbiota and alleviating inflammatory ...

Mingfei Yao, Yanmeng Lu, Ting Zhang, Jiaojiao **e… in npj Biofilms and Microbiomes (2021)

Article

Diethyldithiocarbamate-copper complex (CuET) inhibits colorectal cancer progression via miR-16-5p and 15b-5p/ALDH1A3/PKM2 axis-mediated aerobic glycolysis pathway

Exploring novel anticancer drugs to optimize the efficacy may provide a benefit for the treatment of colorectal cancer (CRC). Disulfiram (DSF), as an antialcoholism drug, is metabolized into diethyldithiocarba...

**n Huang, Yichao Hou, **aoling Weng, Wen**g Pang, Lidan Hou, Yu Liang… in Oncogenesis (2021)

Article

Correction to: Remodelin, an inhibitor of NAT10, could suppress hypoxia-induced or constitutional expression of HIFs in cells

The article “Remodelin, an inhibitor of NAT10, could suppress hypoxia-induced or constitutional expression of HIFs in cells”, written by “Yaqian Wu, Yanan Cao, Hai**g Liu, Mengfei Yao, Ningning Ma and Bo Zhan...

Yaqian Wu, Yanan Cao, Hai**g Liu, Mengfei Yao… in Molecular and Cellular Biochemistry (2020)

Article

LINC00675 activates androgen receptor axis signaling pathway to promote castration-resistant prostate cancer progression

The development of prostate cancer (PCa) from androgen-deprivation therapy (ADT) sensitive to castration resistant (CRPC) seriously impacts life quality and survival of PCa patients. Emerging evidence shows th...

Mengfei Yao, **aolei Shi, Yue Li, Yutian **ao, William Butler… in Cell Death & Disease (2020)

Article

Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway

The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as a metabolic regulator in the treatment of metaboli...

Yu Liang, Lidan Hou, Lin**g Li, Lei Li, Liming Zhu, Yu Wang, **n Huang… in Oncogene (2020)

Article

Microvesicles and chemokines in tumor microenvironment: mediators of intercellular communications in tumor progression

Increasing evidence indicates that the ability of cancer cells to convey biological information to recipient cells within the tumor microenvironment (TME) is crucial for tumor progression. Microvesicles (MVs) ...

**aojie Bian, Yu-Tian **ao, Tianqi Wu, Mengfei Yao, Leilei Du… in Molecular Cancer (2019)

Article

Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis

Nosiheptide is a parent compound of thiopeptide family that exhibit potent activities against various bacterial pathogens. Its C-terminal amide formation is catalyzed by NosA, which is an unusual strategy for ...

Shanshan Liu, Heng Guo, Tianlong Zhang, Li Han, Pengfei Yao… in Scientific Reports (2015)

Article

Editorial

Goong Chen, Pengfei Yao, Jiongmin Yong… in Journal of Systems Science and Complexity (2010)