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  1. Article

    Open Access

    Transcriptional repression of beige fat innervation via a YAP/TAZ-S100B axis

    Sympathetic innervation is essential for the development of functional beige fat that maintains body temperature and metabolic homeostasis, yet the molecular mechanisms controlling this innervation remain larg...

    Xun Huang, **nmeng Li, Hongyu Shen, Yiheng Zhao, Zhao Zhou… in Nature Communications (2023)

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  2. Article

    Open Access

    The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis

    Fibrosis disrupts adipose tissue (AT) homeostasis and exacerbates metabolic dysfunction upon chronic caloric excess. The molecular mechanisms linking adipocyte plasticity to AT fibrosis are largely unknown. He...

    Hongyu Shen, Xun Huang, Yiheng Zhao, Dongmei Wu, Kaili Xue… in Nature Communications (2022)

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  3. No Access

    Article

    Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation

    Metabolic inflammation is closely linked to obesity, and is implicated in the pathogenesis of metabolic diseases. FTO harbors the strongest genetic association with polygenic obesity, and IRX3 mediates the effect...

    **gfei Yao, Dongmei Wu, Chunyan Zhang, Ting Yan, Yiheng Zhao… in Nature Immunology (2021)