61 Result(s)

Article

Genome analysis and signature discovery for diving and sensory properties of the endangered Chinese alligator

Crocodilians are diving reptiles that can hold their breath under water for long periods of time and are crepuscular animals with excellent sensory abilities. They comprise a sister lineage of birds and have n...

Qiu-Hong Wan, Sheng-Kai Pan, Li Hu, Ying Zhu, Peng-Wei Xu, **-Quan **a… in Cell Research (2013)

Article

Evaluation of islets derived from human fetal pancreatic progenitor cells in diabetes treatment

With the shortage of donor organs for islet transplantation, insulin-producing cells have been generated from different types of stem cell. Human fetal pancreatic stem cells have a better self-renewal capacity...

Wen-Jian Zhang, Shi-Qing Xu, Han-Qing Cai, **u-Li Men… in Stem Cell Research & Therapy (2013)

Article

Recurrent mutations at C-reactive protein gene promoter SNP position −286 in human cancers

Ming-Yu Wang, Hai-Hong Zhou, Shi-Chao Zhang, Feng Hui, Wei Zhu… in Cell Research (2014)

Article

Hydrogen peroxide primes heart regeneration with a derepression mechanism

While the adult human heart has very limited regenerative potential, the adult zebrafish heart can fully regenerate after 20% ventricular resection. Although previous reports suggest that developmental signali...

Peidong Han, **ao-Hai Zhou, Nannan Chang, Cheng-Lu **ao, Shouyu Yan… in Cell Research (2014)

Article

Acyclic retinoid induces differentiation and apoptosis of murine hepatic stem cells

The therapeutic potential of acyclic retinoid (ACR), a synthetic retinoid, has been confirmed in experimental and clinical studies. Therapeutic targets include precancerous and cancer stem cells. As ACR is als...

Hong-Bin Guan, Yun-Zhong Nie, Yun-Wen Zheng… in Stem Cell Research & Therapy (2015)

Article

G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition

In vertebrates, embryonic hematopoietic stem and progenitor cells (HSPCs) are derived from a subset of endothelial cells, the hemogenic endothelium (HE), through the endothelial-to-hematopoietic transition (EH...

Panpan Zhang, Qiu** He, Dongbo Chen, Weixiao Liu, Lu Wang, Chunxia Zhang… in Cell Research (2015)

Article

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

Anaphase-promoting complex/cyclosome/Cdh1 is a multi-subunit ubiquitin E3 ligase that drives M to G1 cell cycle progression through primarily earmarking various substrates for ubiquitination and subsequent deg...

Jia Liu, Lixin Wan, **g Liu, Zhu Yuan, **fang Zhang, Jianfeng Guo… in Cell Discovery (2016)

Article

Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication

As noted by Darwin, chickens have the greatest phenotypic diversity of all birds, but an interesting evolutionary difference between domestic chickens and their wild ancestor, the Red Junglefowl, is their comp...

Ming-Shan Wang, Rong-wei Zhang, Ling-Yan Su, Yan Li, Min-Sheng Peng… in Cell Research (2016)

Article

Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid

Craniofacial anomalies (CFAs) characterized by birth defects of skull and facial bones are the most frequent congenital disease. Genomic analysis has identified multiple genes responsible for CFAs; however, th...

Rui Shao, Jia Liu, Guang Yan, **fang Zhang, Yujiao Han, Jianfeng Guo… in Cell Research (2016)

Article

Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome

PRKAG2 cardiac syndrome is an autosomal dominant inherited disease resulted from mutations in the PRKAG2 gene that encodes γ2 regulatory subunit of AMP-activated protein kinase. Affected patients usually develop ...

Chang **e, Ya-** Zhang, Lu Song, Jie Luo, Wei Qi, Jialu Hu, Danbo Lu… in Cell Research (2016)

Article

Questions about NgAgo

Shawn Burgess, Linzhao Cheng, Feng Gu, Junjiu Huang, Zhiwei Huang… in Protein & Cell (2016)

Article

Erratum to: Questions about NgAgo

Shawn Burgess, Linzhao Cheng, Feng Gu, Junjiu Huang, Zhiwei Huang… in Protein & Cell (2017)

Article

Mass spectrometry based proteomics profiling of human monocytes

Human monocyte is an important cell type which is involved in various complex human diseases. To better understand the biology of human monocytes and facilitate further studies, we developed the first comprehe...

Yong Zeng, Fei-Yan Deng, Wei Zhu, Lan Zhang, Hao He, Chao Xu, Qing Tian… in Protein & Cell (2017)

Article

Cryo-EM structure of Nma111p, a unique HtrA protease composed of two protease domains and four PDZ domains

Li Zhang, **ao**g Wang, Fenghui Fan, Hong-Wei Wang, Jiawei Wang… in Cell Research (2017)

Article

Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity

Triple-negative breast cancer (TNBC) remains a clinical challenge because of the absence of effective therapeutic targets. In TNBC, overexpression of YAP and TAZ correlates with bioactivities of cancer stem ce...

Ying-Wei Li, Jian Xu, Guo-Yuan Zhu, Zhu-Juan Huang, Yan Lu… in Cell Death Discovery (2018)

Article

Selective cell death of latently HIV-infected CD4⁺ T cells mediated by autosis inducing nanopeptides

Despite significant advances in the treatment of human immunodeficiency virus type-1 (HIV) infection, antiretroviral therapy only suppresses viral replication but is unable to eliminate infection. Thus, discon...

Gang Zhang, Brian T. Luk, **aoli Wei, Grant R. Campbell… in Cell Death & Disease (2019)

Article

Author Correction: Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2

Since the publication of the article, the authors became aware that Figs. 1c, 5k and 6m contained errors in representative image and PAS score in control groups. The corrected Figs. 1c, 5k, and 6m are given be...

Li-xia **a, Wen Hua, Yan **, Bao-** Tian, Zhang-wei Qiu… in Cell Death & Differentiation (2019)

Article

Two functional variants at 6p21.1 were associated with lean mass

Low lean body mass is the most important predictor of sarcopenia with strong genetic background. The aim of this study was to uncover genetic factors underlying lean mass development.

Yu-Fang Pei, Wen-Zhu Hu, **ao-Lin Yang, **n-Tong Wei, Gui-Juan Feng… in Skeletal Muscle (2019)

Article

Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1

Multisystem manifestations in myotonic dystrophy type 1 (DM1) may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK, including DMPK, its neighboring genes (SIX5 or

Qi Yin, Hongye Wang, Na Li, Yifu Ding, Zhenfei **e, Lifang **, Yan Li… in Cell Research (2020)

Article

Simulated microgravity significantly altered metabolism in epidermal stem cells

Simulated microgravity can significantly affect various cell types and multiple systems of the human body, such as cardiovascular system, skeletal muscle system, and immune system, and is known to cause anemia...

Bin-Bin Li, Zheng-Yang Chen, Nan Jiang… in In Vitro Cellular & Developmental Biology … (2020)