43 Result(s)
within
**g-Liang Chung
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessEstablishment and risk factor assessment of the abnormal body temperature probability prediction model (ABTP) for dairy cattle
The study aims to develop an abnormal body temperature probability (ABTP) model for dairy cattle, utilizing environmental and physiological data. This model is designed to enhance the management of heat stress...
-
Article
Open AccessDCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently eme...
-
Article
Open AccessIntracellular RNA and DNA tracking by uridine-rich internal loop tagging with fluorogenic bPNA
The most widely used method for intracellular RNA fluorescence labeling is MS2 labeling, which generally relies on the use of multiple protein labels targeted to multiple RNA (MS2) hairpin structures installed...
-
Article
Open AccessSocial network analysis of nationwide interhospital emergency department transfers in Taiwan
Transferring patients between emergency departments (EDs) is a complex but important issue in emergency care regionalization. Social network analysis (SNA) is well-suited to characterize the ED transfer patter...
-
Article
Open AccessExploration of the relationship between gut microbiota and fecal microRNAs in patients with major depressive disorder
Microbiota-gut-brain axis signaling plays a pivotal role in mood disorders. The communication between the host and the gut microbiota may involve complex regulatory networks. Previous evidence showed that host...
-
Article
Open AccessAccelerated water activation and stabilized metal-organic framework via constructing triangular active-regions for ampere-level current density hydrogen production
Two-dimensional metal-organic frameworks (MOFs) have been explored as effective electrocatalysts for hydrogen evolution reaction (HER). However, the sluggish water activation kinetics and structural instabilit...
-
Article
Open AccessPatient-derived tumor organoids as a platform of precision treatment for malignant brain tumors
Malignant brain tumors consist of malignancies originated primarily within the brain and the metastatic lesions disseminated from other organs. In spite of intensive studies, malignant brain tumors remain to b...
-
Article
Open AccessAuthor Correction: A multicenter study to compare the effectiveness of the inpatient post acute care program versus traditional rehabilitation for stroke survivors
-
Article
Open AccessA multicenter study to compare the effectiveness of the inpatient post acute care program versus traditional rehabilitation for stroke survivors
There is insufficient evidence to prove the effect of the Post-acute Care (PAC) program on post-stroke recovery. This study aimed to determine the effectiveness of the PAC versus traditional inpatient rehabili...
-
Article
Open AccessDeep neural network trained on gigapixel images improves lymph node metastasis detection in clinical settings
The pathological identification of lymph node (LN) metastasis is demanding and tedious. Although convolutional neural networks (CNNs) possess considerable potential in improving the process, the ultrahigh-reso...
-
Article
Open AccessThe impact of driver mutation on the treatment outcome of early-stage lung cancer patients receiving neoadjuvant immunotherapy and chemotherapy
Neoadjuvant immunotherapy and chemotherapy have improved the major pathological response (MPR) in patients with early-stage operable non-small cell lung cancer (NSCLC). This study aimed to assess whether the p...
-
Article
Open AccessAssessment of total and regional bone mineral density using bioelectrical impedance vector analysis in elderly population
This study aimed to investigate the relationship between bone mineral density (BMD) and height-adjusted resistance (R/H), reactance (Xc/H) and phase angle (PhA). A total of 61 male and 64 female subjects aged ...
-
Article
Open AccessEradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic antibody libraries
Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and hence there are increasing needs to develop MSLN-targeting strategies for cancer therapeutics. Antibody–drug conjugates...
-
Article
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by a coronavirus, following the emergence of severe acute respiratory syndrome (SARS) in 20031 and Middle East respiratory syn...
-
Article
Open AccessUltra-strong polymeric hollow fiber membranes for saline dewatering and desalination
Osmotically assisted reverse osmosis (OARO) has become an emerging membrane technology to tackle the limitations of a reverse osmosis (RO) process for water desalination. A strong membrane that can withstand a...
-
Article
Open AccessChanging epidemiology and viral interplay of hepatitis B, C and D among injecting drug user-dominant prisoners in Taiwan
The spreading of viral hepatitis among injecting drug users (IDU) is an emerging public health concern. This study explored the prevalence and the risks of hepatitis B virus (HBV), hepatitis C virus (HCV) and ...
-
Article
Open AccessRole of hepatitis D virus infection in development of hepatocellular carcinoma among chronic hepatitis B patients treated with nucleotide/nucleoside analogues
Hepatitis D virus (HDV) infection increases the risk of hepatocellular carcinoma (HCC) in the natural course of chronic hepatitis B (CHB) patients. Its role in patients treated with nucleotide/nucleoside analo...
-
Article
Open AccessTreatment outcomes of pediatric acute myeloid leukemia: a retrospective analysis from 1996 to 2019 in Taiwan
Improvement in outcomes of children with acute myeloid leukemia (AML) is attributed to several refinements in clinical management. We evaluated treatment outcomes of Taiwanese pediatric AML patients in the pas...
-
Article
Open AccessConstruction of intracellular asymmetry and asymmetric division in Escherichia coli
The design principle of establishing an intracellular protein gradient for asymmetric cell division is a long-standing fundamental question. While the major molecular players and their interactions have been e...
-
Article
Open AccessFPGS relapse-specific mutations in relapsed childhood acute lymphoblastic leukemia
Although the cure rate for childhood acute lymphoblastic leukemia (ALL) has exceeded 80% with contemporary therapy, relapsed ALL remains a leading cause of cancer-related death in children. Relapse-specific mu...
