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114 Result(s)
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Article
Open AccessEfficient electrochemical reduction of nitrate to ammonia over metal-organic framework single-atom catalysts
The design and preparation of efficient catalysts for ammonia production under mild conditions is a desirable but highly challenging target. Here, we report a series of single-atom catalysts [M-SACs, M = Mn(II...
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Article
Open AccessDCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance
Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently eme...
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Article
Open AccessWork Motivation Is Not Generational but Depends on Age and Period
Many argue that work motivation varies with year of birth, suggesting the utility of generational labels such as Z, Y, X, or Baby Boomer. This article tests this generational hypothesis by using multilevel reg...
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Article
Open AccessEfficient capture and storage of ammonia in robust aluminium-based metal-organic frameworks
The development of stable sorbent materials to deliver reversible adsorption of ammonia (NH3) is a challenging task. Here, we report the efficient capture and storage of NH3 in a series of robust microporous alum...
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Article
Author Correction: Direct photo-oxidation of methane to methanol over a mono-iron hydroxyl site
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Article
Direct photo-oxidation of methane to methanol over a mono-iron hydroxyl site
Natural gas, consisting mainly of methane (CH4), has a relatively low energy density at ambient conditions (~36 kJ l−1). Partial oxidation of CH4 to methanol (CH3OH) lifts the energy density to ~17 MJ l−1 and dri...
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Article
Open AccessHow human capital, universities of excellence, third party funding, mobility and gender explain productivity in German political science
Using a unique panel dataset of virtually all German academic political scientists, we show that researchers become much more productive due to the accumulation of human capital and third party funding. We als...
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Article
Open AccessConstruction of C-C bonds via photoreductive coupling of ketones and aldehydes in the metal-organic-framework MFM-300(Cr)
Construction of C-C bonds via reductive coupling of aldehydes and ketones is hindered by the highly negative reduction potential of these carbonyl substrates, particularly ketones, and this renders the formati...
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Chapter
Schlüsselwerke im Portrait
Niccolò Machiavelli wird am 3. Mai 1469 in Florenz geboren. Seine humanistische Ausbildung bereitet ihn auf Wunsch des Vaters auf eine politische Laufbahn vor. Am 19. Juni 1498 wird er vom Großen Rat, der Bürg...
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Article
Open AccessA triple farnesoid X receptor and peroxisome proliferator-activated receptor α/δ activator reverses hepatic fibrosis in diet-induced NASH in mice
Non-alcoholic steatohepatitis (NASH) - a hepatic manifestation of the metabolic syndrome - is a multifactorial disease with alarming global prevalence. It involves steatosis, inflammation and fibrosis in the l...
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Article
Open AccessMen Lose Life Satisfaction with Fewer Hours in Employment: Mothers Do Not Profit from Longer Employment—Evidence from Eight Panels
This article uses random and fixed effects regressions with 743,788 observations from panels of East and West Germany, the UK, Australia, South Korea, Russia, Switzerland and the United States. It shows how th...
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Article
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase
The mitotic kinase AURORA-A is essential for cell cycle progression and is considered a priority cancer target. Although the catalytic activity of AURORA-A is essential for its mitotic function, recent reports...
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Article
Open AccessElectro-reduction of carbon dioxide at low over-potential at a metal–organic framework decorated cathode
Electrochemical reduction of carbon dioxide is a clean and highly attractive strategy for the production of organic products. However, this is hindered severely by the high negative potential required to activ...
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Article
p63 uses a switch-like mechanism to set the threshold for induction of apoptosis
The p53 homolog TAp63α is the transcriptional key regulator of genome integrity in oocytes. After DNA damage, TAp63α is activated by multistep phosphorylation involving multiple phosphorylation events by the k...
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Article
Open AccessRefinement of pore size at sub-angstrom precision in robust metal–organic frameworks for separation of xylenes
The demand for xylenes is projected to increase over the coming decades. The separation of xylene isomers, particularly p- and m-xylenes, is vital for the production of numerous polymers and materials. However, c...
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Article
Open AccessHepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication
Hepatitis Delta virus (HDV) is a satellite of Hepatitis B virus with a single-stranded circular RNA genome. HDV RNA genome synthesis is carried out in infected cells by cellular RNA polymerases with the assist...
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Living Reference Work Entry At a glance
Garbe, Robert
1892–1898 Lehrerseminar, 1899–1927 Schuldienst in Hamburg; lebenslang kränkelnd; 1904 Gründer des ‚Saxnotbund‘, aus dem 1906 die ‚Nedderdüütsh Sellshopp‘ hervorging, die erfolglos eine einheitliche Schreibung ...
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Living Reference Work Entry At a glance
Boßdorf, Hermann
Erlernte während seiner Ausbildung zum Telegraphenassistenten skandinavische Sprachen; starkes Interesse für nordische Literatur; niederdeutsche Übersetzungsversuche an einem Drama August Strindbergs
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Living Reference Work Entry At a glance
Peters, Friedrich Ernst
1905–1911 Lehrerausbildung; 1911–1914 Dorflehrer in Schleswig-Holstein; 1914–1920 in französischer Kriegsgefangenschaft; 1920–1923 Ausbildung zum Taubstummenlehrer in Berlin; 1923–1945 Lehrer an der Landesgehö...
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Living Reference Work Entry At a glance
Stavenhagen, Fritz
Abgebrochene Lehre als Drogist in Finkenwerder; autodidaktische künstlerische Ausbildung; ärmliche Existenz als freier Autor und Zeichner in Hamburg, München und Berlin; kleine Jahresstipendien durch die Schil...