124 Result(s)

Article

Estrogen-immuno-neuromodulation disorders in menopausal depression

A significant decrease in estrogen levels puts menopausal women at high risk for major depression, which remains difficult to cure despite its relatively clear etiology. With the discovery of abnormally elevat...

Yuling Zhang, **ying Tan, Chaozhi Tang in Journal of Neuroinflammation (2024)

Article

NR1 Splicing Variant NR1a in Cerebellar Granule Neurons Constitutes a Better Motor Learning in the Mouse

As an excitatory neuron in the cerebellum, the granule cells play a crucial role in motor learning. The assembly of NMDAR in these neurons varies in developmental stages, while the significance of this variety...

Ting Tan, Linyan Jiang, Zhengxiao He, Xuejiao Ding, … in The Cerebellum (2024)

Article

Therapeutic effects of orexin-A in sepsis-associated encephalopathy in mice

Sepsis-associated encephalopathy (SAE) causes acute and long-term cognitive deficits. However, information on the prevention and treatment of cognitive dysfunction after sepsis is limited. The neuropeptide ore...

**g Guo, Zhuo Kong, Sha Yang, **g**g Da, Liangzhao Chu… in Journal of Neuroinflammation (2024)

Article

[1-¹¹C]-Butanol Positron Emission Tomography reveals an impaired brain to nasal turbinates pathway in aging amyloid positive subjects

Reduced clearance of cerebrospinal fluid (CSF) has been suggested as a pathological feature of Alzheimer’s disease (AD). With extensive documentation in non-human mammals and contradictory human neuroimaging d...

Neel H. Mehta, **uyuan Wang, Samantha A. Keil, Ke **… in Fluids and Barriers of the CNS (2024)

Article

Inhibiting the NLRP3 Inflammasome with MCC950 Alleviates Neurological Impairment in the Brain of EAE Mice

Multiple sclerosis (MS) is a chronic disease that is characterized by demyelination and neuronal damage. Experimental autoimmune encephalomyelitis (EAE) mice are used to model the disease progression of MS and...

Baohua Hou, Jun Yin, Shuyan Liu, **cheng Guo, Baobao Zhang… in Molecular Neurobiology (2024)

Article

TGN-020 Alleviate Inflammation and Apoptosis After Cerebral Ischemia–Reperfusion Injury in Mice Through Glymphatic and ERK1/2 Signaling Pathway

Post-stroke acute inhibition of aquaporin 4 (AQP4) is known to exacerbate inflammation and apoptosis, yet the underlying mechanisms are not fully understood. The objective of this study was to investigate the ...

**aohong Li, Zhuoxi **e, Qian Zhou, **aoli Tan, Weiting Meng… in Molecular Neurobiology (2024)

Article

Chorioamnionitis accelerates granule cell and oligodendrocyte maturation in the cerebellum of preterm nonhuman primates

Preterm birth is often associated with chorioamnionitis and leads to increased risk of neurodevelopmental disorders, such as autism. Preterm birth can lead to cerebellar underdevelopment, but the mechanisms of...

Josef Newman, **aoying Tong, April Tan, Toni Yeasky… in Journal of Neuroinflammation (2024)

Article

The role of Nurr1-miR-30e-5p-NLRP3 axis in inflammation-mediated neurodegeneration: insights from mouse models and patients’ studies in Parkinson’s disease

Nuclear receptor related-1 (Nurr1), a ligand-activated transcription factor, is considered a potential susceptibility gene for Parkinson’s disease (PD), and has been demonstrated to possess protective effects ...

Tianbai Li, **ang Tan, Lulu Tian, Congcong Jia, Cheng Cheng… in Journal of Neuroinflammation (2023)

Article

Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology

Alzheimer’s disease (AD) pathology and amyloid-beta (Aβ) plaque deposition progress slowly in the cerebellum compared to other brain regions, while the entorhinal cortex (EC) is one of the most vulnerable regi...

Jessica R. Gaunt, Norliyana Zainolabidin, Alaric K. K. Yip… in Journal of Neuroinflammation (2023)

Article

CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery

Acute stroke leads to the activation of myeloid cells. These cells express adhesion molecules and transmigrate to the brain, thereby aggravating injury. Chronically after stroke, repair processes, including an...

Justin N. Nguyen, Eric C. Mohan, Gargee Pandya, Uzma Ali… in Journal of Neuroinflammation (2023)

Article

Stabilizing histamine release in gut mast cells mitigates peripheral and central inflammation after stroke

Stroke is the most common cause of long-term disability and places a high economic burden on the global healthcare system. Functional outcomes from stroke are largely determined by the extent of ischemic injur...

Maria P. Blasco Conesa, Frank W. Blixt, Pedram Peesh… in Journal of Neuroinflammation (2023)

Article

Author Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia

**aowei Zhu, Bo Zhou, Reenal Pattni, Kelly Gleason, Chunfeng Tan… in Nature Neuroscience (2023)

Article

Rat Hair Metabolomics Analysis Reveals Perturbations of Unsaturated Fatty Acid Biosynthesis, Phenylalanine, and Arachidonic Acid Metabolism Pathways Are Associated with Amyloid-β-Induced Cognitive Deficits

Hair is a noninvasive valuable biospecimen for the long-term assessment of endogenous metabolic disturbance. Whether the hair is suitable for identifying biomarkers of the Alzheimer’s disease (AD) process rema...

Tian-Hoe Tan, Shih-Wen Li, Chih-Wei Chang, Yuan-Chih Chen… in Molecular Neurobiology (2023)

Article

Emerging role of non-coding RNAs in neuroinflammation mediated by microglia and astrocytes

Neuroinflammation has been implicated in the initiation and progression of several central nervous system (CNS) disorders, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, mul...

Ruicheng Yang, Bo Yang, Wei Liu, Chen Tan, Huanchun Chen… in Journal of Neuroinflammation (2023)

Article

Ambient RNAs removal of cortex-specific snRNA-seq reveals Apoe⁺ microglia/macrophage after deeper cerebral hypoperfusion in mice

Ambient RNAs contamination in single-nuclei RNA sequencing (snRNA-seq) is a challenging problem, but the consequences of ambient RNAs contamination of damaged and/or diseased tissues are poorly understood. Cog...

Yuan Zhang, **yun Tan, Kai Yang, Weijian Fan, Bo Yu… in Journal of Neuroinflammation (2023)

Article

Lactobacillus paracasei L9 affects disease progression in experimental autoimmune neuritis by regulating intestinal flora structure and arginine metabolism

Autoimmune neuropathies are common peripheral nervous system (PNS) disorders. Environmental influences and dietary components are known to affect the course of autoimmune diseases. Intestinal microorganisms ca...

Yuting Meng, **angjie Qiu, Zhongxiang Tang, Yu Mao… in Journal of Neuroinflammation (2023)

Article

Prefrontal engrams of long-term fear memory perpetuate pain perception

A painful episode can lead to a life-long increase in an individual’s experience of pain. Fearful anticipation of imminent pain could play a role in this phenomenon, but the neurobiological underpinnings are u...

Alina Stegemann, Sheng Liu, Oscar Andrés Retana Romero… in Nature Neuroscience (2023)

Article

The Key Drivers of Brain Injury by Systemic Inflammatory Responses after Sepsis: Microglia and Neuroinflammation

Sepsis is a leading cause of intensive care unit admission and death worldwide. Most surviving patients show acute or chronic mental disorders, which are known as sepsis-associated encephalopathy (SAE). Althou...

Yuewen **n, Mi Tian, Shuixiang Deng, Jiaying Li, Miaoxian Yang… in Molecular Neurobiology (2023)

Article

Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-β and tau pathology in Alzheimer’s disease

Dysfunction of glial cell communication is involved in Alzheimer’s disease (AD) pathogenesis, and the recent study reported that astrocytic secreted interleukin-3 (IL-3) participated in astrocyte–microglia cro...

Zhi-Bo Wang, Ya-Hui Ma, Yan Sun, Lan Tan, Hui-Fu Wang… in Journal of Neuroinflammation (2022)

Article

Understanding protective and risk factors affecting adolescents’ well-being during the COVID-19 pandemic

This study investigated the factors affecting adolescents’ well-being during the COVID-19 pandemic from the perspectives of their participation in digital activities, emotional regulation, self-regulated learn...

Min Lan, Qianqian Pan, Cheng Yong Tan, Nancy Wai Ying Law in npj Science of Learning (2022)