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Article
Open AccessHistone serotonylation in dorsal raphe nucleus contributes to stress- and antidepressant-mediated gene expression and behavior
Mood disorders are an enigmatic class of debilitating illnesses that affect millions of individuals worldwide. While chronic stress clearly increases incidence levels of mood disorders, including major depress...
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Article
Open AccessCirculating neutrophils from patients with early breast cancer have distinct subtype-dependent phenotypes
An elevated number of circulating neutrophils is a poor prognostic factor for breast cancer, where evidence of bone marrow cancer-dependent priming is found. However, how early this priming is detectable remai...
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Article
Author Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia
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Article
Open AccessParticipatory evaluation of the process of co-producing resources for the public on data science and artificial intelligence
The growth of data science and artificial intelligence offers novel healthcare applications and research possibilities. Patients should be able to make informed choices about using healthcare. Therefore, they ...
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Article
Open AccessComparison of phenomics and cfDNA in a large breast screening population: the Breast Screening and Monitoring Study (BSMS)
To assess their roles in breast cancer diagnostics, we aimed to compare plasma cell-free DNA (cfDNA) levels with the circulating metabolome in a large breast screening cohort of women recalled for mammography,...
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Article
Open AccessShallow WGS of individual CTCs identifies actionable targets for informing treatment decisions in metastatic breast cancer
We report copy-number profiling by low-pass WGS (LP-WGS) in individual circulating tumour cells (CTCs) for guiding treatment in patients with metastatic breast cancer (MBC), comparing CTC results with mutation...
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Article
Open AccessChromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia
Schizophrenia (SZ) is a psychiatric disorder with complex genetic risk dictated by interactions between hundreds of risk variants. Epigenetic factors, such as histone posttranslational modifications (PTMs), ha...
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Article
Hippocampal subfield transcriptome analysis in schizophrenia psychosis
We have previously demonstrated functional and molecular changes in hippocampal subfields in individuals with schizophrenia (SZ) psychosis associated with hippocampal excitability. In this study, we use RNA-se...
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Article
Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia
Retrotransposons can cause somatic genome variation in the human nervous system, which is hypothesized to have relevance to brain development and neuropsychiatric disease. However, the detection of individual ...
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Article
Open AccessPlasma cell-free DNA (cfDNA) as a predictive and prognostic marker in patients with metastatic breast cancer
Breast cancer (BC) is the most common cancer in women, and despite the introduction of new screening programmes, therapies and monitoring technologies, there is still a need to develop more useful tests for mo...
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Article
ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior
Upregulation of the ATP-dependent ACF chromatin-remodeling complex in the NAc is a necessary and causal component for susceptibility to stress-induced depressive behaviors in mice, and this complex is also sho...
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A Monumental Distance: Education and Outreach from the Most Remote Archipelago on Earth
Beyond the main eight populated islands of Hawai’i lies Papahānaumokuākea Marine National Monument (PMNM). On 15 June 2006, President George W. Bush established PMNM, and on 30 July 2010, the World Heritage Co...
