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Article
Open AccessMitochondrial RNA modification-based signature to predict prognosis of lower grade glioma: a multi-omics exploration and verification study
Mitochondrial RNA modification (MRM) plays a crucial role in regulating the expression of key mitochondrial genes and promoting tumor metastasis. Despite its significance, comprehensive studies on MRM in lower...
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Article
Open AccessTherapeutic effects of orexin-A in sepsis-associated encephalopathy in mice
Sepsis-associated encephalopathy (SAE) causes acute and long-term cognitive deficits. However, information on the prevention and treatment of cognitive dysfunction after sepsis is limited. The neuropeptide ore...
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Article
Open AccessAdvances in the antitumor mechanisms of tripartite motif-containing protein 3
The tripartite motif-containing (TRIM) protein family has steadily become a hotspot in tumor-related research. As a member of the E3 ubiquitin ligase family, TRIM is working on many crucial biological processe...
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Article
Open AccessTPPP3 promote epithelial-mesenchymal transition via Snail1 in glioblastoma
Tubulin polymerization promoting protein 3 (TPPP3), a member of the tubulin polymerization family, participates in cell progressions in several human cancers, its biological function and the underlying mechani...
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Article
Open AccessUSP10 deubiquitinates RUNX1 and promotes proneural-to-mesenchymal transition in glioblastoma
The mesenchymal (MES) subtype of glioblastoma (GBM) is a highly aggressive, malignant and proliferative cancer that is resistant to chemotherapy. Runt-related transcription factor 1 (RUNX1) was shown to suppor...
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Article
Open AccessCircular RNA circPOSTN promotes neovascularization by regulating miR-219a-2-3p/STC1 axis and stimulating the secretion of VEGFA in glioblastoma
Glioblastoma (GBM), the most malignant type of astrocytic tumor, is one of the deadliest cancers prevalent in adults. Along with tumor growth, patients with GBM generally suffer from extensive cerebral edema a...
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Article
Open AccessCircPOSTN/miR-361-5p/TPX2 axis regulates cell growth, apoptosis and aerobic glycolysis in glioma cells
Glioma is the most primary central nervous system tumor in adults. The 5 year survival rate for glioma patients remains poor, although treatment strategies had improved in the past few decades. The cumulative ...
