91 Result(s)
within
**g Ying Cheng
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessHER2-targeting antibody drug conjugate FS-1502 in HER2-expressing metastatic breast cancer: a phase 1a/1b trial
Currently approved HER2-targeting antibody-drug conjugates (ADCs) for HER2-positive breast cancer (BC) are associated with safety concerns. In this multicenter, single-arm, dose-escalation (phase 1a) and dose-...
-
Article
Open AccessReservoir-computing based associative memory and itinerancy for complex dynamical attractors
Traditional neural network models of associative memories were used to store and retrieve static patterns. We develop reservoir-computing based memories for complex dynamical attractors, under two common recal...
-
Article
Open AccessCompact meta-differentiator for achieving isotropically high-contrast ultrasonic imaging
Ultrasonic imaging is crucial in the fields of biomedical engineering for its deep penetration capabilities and non-ionizing nature. However, traditional techniques heavily rely on impedance differences within...
-
Article
Open AccessA pivotal bridging study of lurbinectedin as second-line therapy in Chinese patients with small cell lung cancer
This single-arm, multi-center clinical trial aimed to evaluate the safety, tolerability, DLT, recommended dose (RD), preliminary efficacy, and pharmacokinetics (PK) characteristics of lurbinectedin, a selectiv...
-
Article
Open AccessDynamic phenotypic reprogramming and chemoresistance induced by lung fibroblasts in small cell lung cancer
Small cell lung cancer (SCLC) is heterogenous in phenotype and microenvironment. Dynamic phenotypic reprogramming, leading to heterogeneity, is prevalent in SCLC, while the mechanisms remain incompletely under...
-
Article
Open AccessThe status of binocular visual functions among Taiwan high-tech industry engineers and its correlation with computer vision symptom
To analyze the status of binocular visual functions, the relationship between binocular visual function and computer vision-related symptoms in the high-tech industry group. The study sample was comprised of 3...
-
Article
Open AccessUnlabeled data selection for active learning in image classification
Active Learning has emerged as a viable solution for addressing the challenge of labeling extensive amounts of data in data-intensive applications such as computer vision and neural machine translation. The ma...
-
Article
Open AccessNanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery
The oral delivery of nano-drug delivery systems (Nano-DDS) remains a challenge. Taking inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles (NPs, ~80 nm) with virus-like nano...
-
Article
Open AccessThe influence of large-diameter multifocal contact lens on ocular surface, visual quality, and visual function for presbyopic adults with dry eye syndromes
This study investigated the influence of large-diameter multifocal contact lenses on the ocular surface, visual quality, and visual function for presbyopic adults with dry eye syndromes. The study enrolled 40–...
-
Article
Open AccessModel-free tracking control of complex dynamical trajectories with machine learning
Nonlinear tracking control enabling a dynamical system to track a desired trajectory is fundamental to robotics, serving a wide range of civil and defense applications. In control engineering, designing tracki...
-
Article
Open AccessAuthor Correction: Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer
-
Article
Open AccessCandidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer
Osimertinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), potently and selectively inhibits EGFR-TKI-sensitizing and EGFR T790M resistance mutations. In the Phase III FLAURA study ...
-
Article
Open AccessAge-specific trend and birth cohort effect on different histologic types of uterine corpus cancers
To evaluate the uterine corpus cancer incidence rates, age-specific trends, and birth cohort patterns by different histologic types. We conducted a retrospective cohort study of uterine cancer patients (n = 28...
-
Article
Open AccessThe rocker-soled shoes change the kinematics and muscle contractions of the lower extremity during various functional movement
While rocker-shaped soles have become popular for running shoes, whether or not this type of shoe benefits other functional movements has rarely been discussed. The purpose of this study was to investigate the...
-
Article
Open AccessRelative tree cover does not indicate a lagged Holocene forest response to monsoon rainfall
-
Article
Open AccessAdipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2
Adipose tissue macrophage (ATM) inflammation is involved with meta-inflammation and pathology of metabolic complications. Here we report that in adipocytes, elevated lactate production, previously regarded as ...
-
Article
Open AccessStructured sonic tube with carbon nanotube-like topological edge states
A single-wall carbon nanotube can be viewed as a one-dimensional material created by rolling up a sheet of graphene. Its electronic band structure depends on the chirality, i.e., how the sheet has been rolled ...
-
Article
Open AccessAuthor Correction: Full reconstruction of simplicial complexes from binary contagion and Ising data
-
Article
Open AccessFull reconstruction of simplicial complexes from binary contagion and Ising data
Previous efforts on data-based reconstruction focused on complex networks with pairwise or two-body interactions. There is a growing interest in networks with higher-order or many-body interactions, raising th...
-
Article
Open AccessThe influence of contact lenses with different optical designs on the binocular vision and visual behavior of young adults
Theoretically, contact lenses change the accommodation and vergence demands of the eyes and directly or indirectly influence binocular vision. The purpose of this study was to investigate the influence of diff...
