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  1. Article

    Open Access

    Modulating DNA damage response in uveal melanoma through embryonic stem cell microenvironment

    Uveal melanoma (UVM) is the most common primary intraocular tumor in adults, with a median survival of 4–5 months following metastasis. DNA damage response (DDR) upregulation in UVM, which could be linked to i...

    Yingxu Zhang, **biao Zheng, Minyu Chen, Shulun Zhao, Ruiqian Ma, Wenwei Chen… in BMC Cancer (2024)

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  2. Article

    Open Access

    Long non-coding RNA OIP5-AS1 suppresses multiple myeloma progression by sponging miR-27a-3p to activate TSC1 expression

    Multiple myeloma (MM) is a prevalent hematological malignancy. Long noncoding RNAs are correlated with the development of MM. In this project, the function of lncRNA opa interacting protein 5-antisense 1 (OIP5...

    Yong Wang, Haibao Wang, Jianwei Ruan, Wenbiao Zheng, Zeyu Yang… in Cancer Cell International (2020)

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  3. Article

    Open Access

    Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasis

    Extracellular signal-regulated kinases (ERKs) have been related to multiple cancers, including breast cancer, hepatocellular cancer, lung cancer and colorectal cancer. ERK1/2 inhibitor can suppress growth of KRAS

    Zilong Yan, Kenoki Ohuchida, Shuang Fei… in Journal of Experimental & Clinical Cancer … (2019)

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  4. No Access

    Article

    CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis

    This study aimed at investigating the function and significance of CD110 expression in pancreatic cancer.

    Zilong Yan, Kenoki Ohuchida, Biao Zheng… in Journal of Cancer Research and Clinical On… (2019)

  5. No Access

    Article

    Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population

    Esophageal squamous cell carcinoma (ESCC) is the dominant type of esophageal cancer in the East Asian population. MicroRNAs (miRNAs) have been studied to play important roles in tumorigenesis. Single nucleotid...

    Fangyuan Shen, Jiejun Chen, Shicheng Guo, Yinghui Zhou, Yabiao Zheng… in Tumor Biology (2016)

  6. No Access

    Article

    miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population

    Esophageal cancer is one of the most aggressive cancers in the world, 70 % of which are from China and esophageal squamous cell carcinoma (ESCC) is the major histopathological form (>90 %). The single nucleoti...

    ** Zhang, Jianguo Wang, Ting Lu, **aofeng Wang, Yabiao Zheng… in Tumor Biology (2015)

  7. No Access

    Article

    Polymorphism in PHD1 gene and risk of non-small cell lung cancer in a Chinese population

    Hypoxia is a common phenomenon in the development of solid tumors, and hypoxia inducible factor 1 (HIF-1) plays a central role in coordinating the cellular response to hypoxia and in oxygen homeostasis. The pr...

    Jianhua Che, Dong Jiang, Yabiao Zheng, Bin Zhu, ** Zhang, Deyi Lu… in Tumor Biology (2014)

  8. No Access

    Article

    Potentiation of the Immune System by Schiff Base-Forming Drugs

    CD4+ T lymphocytes, which orchestrate immune responses, receive a cognitive signal when clonally distributed receptors are occupied by peptides bound to major histocompatibility complex (MHC) class II molecule...

    Huaqing Chen, Simon Hall, Biao Zheng, Dr John Rhodes in BioDrugs (1997)