18 Result(s)
within
**awei Shi
Life Sciences
English
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Article
Tandem PDZ repeats in glutamate receptor–interacting proteins have a novel mode of PDZ domain–mediated target binding
The interaction of the glutamate receptor subunits 2 and 3 (GluR2/3) with multi-PDZ domain glutamate receptor–interacting protein (GRIP) is important for the synaptic trafficking and clustering of the receptor...
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Article
Subunit dissociation and stability alteration of d-hydantoinase deleted at the terminal amino acid residue
Two variants of d-hydantoinase (HYD), created by deletion of one amino acid residue of at either the N- or C-terminus, were expressed in Escherichia coli and purified by two-step chromatography. Compared with HYD...
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Article
A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo
Sorting nexins (SNXs) are phosphoinositide-binding proteins implicated in the sorting of various membrane proteins in vitro, but the in vivo functions of them remain largely unknown. We reported previously that S...
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Article
Gender-related differences in adaptability to drought stress in the dioecious tree Ginkgo biloba
Ginkgo (Ginkgo biloba) as a precious relict plant is cultivated around the world, and it is also a typical dioecious tree. Drought is a major environmental stress that limits the growth and development of ginkgo....
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Article
Effects of exogenous nitric oxide on the photosynthetic characteristics of bamboo (Indocalamus barbatus McClure) seedlings under acid rain stress
The effects of the exogenous application of nitric oxide (NO, in the form of sodium nitroprusside, SNP) on the diurnal variation in photosynthesis, chlorophyll content, chlorophyll fluorescence, light response...
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Article
Open AccessTitanium particle-induced osteogenic inhibition and bone destruction are mediated by the GSK-3β/β-catenin signal pathway
Wear debris-induced osteogenic inhibition and bone destruction are critical in the initiation of peri-prosthetic osteolysis. However, the molecular mechanism underlying this phenomenon is poorly understood. In...
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Article
Open AccessProlactin inhibits the progression of intervertebral disc degeneration through inactivation of the NF-κB pathway in rats
Intervertebral disc degeneration (IVDD) is one of the key predisposing factors for low back pain. Although the exact mechanism remains unclear, inflammatory response and nucleus pulposus (NP) apoptosis are kno...
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Article
cDNA cloning of gs, gogat, and gdh from Haematococcus pluvialis and transcription and enzyme level analysis in different nitrogen concentration
Haematococcus pluvialis has attracted attention due to its ability to produce astaxanthin, which has many functions such as antioxidation and anticancer. In order to further understand its nitrogen metabolism, th...
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Article
Gene Cloning, Expression, and Antifungal Activities of Permatin from Naked Oat (Avena nuda)
Thaumatin-like proteins (TLPs) are the products of a large, highly complex gene family involved in host defense. TLPs also belong to the pathogenesis-related family 5 (PR-5) of plant defense proteins. Most TLP...
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Article
Open AccessEffect of stem cell transplantation on patients with ischemic heart failure: a systematic review and meta-analysis of randomized controlled trials
Stem cell transplantation (SCT) has become a promising way to treat ischemic heart failure (IHF). We performed a large-scale meta-analysis of randomized clinical trials to investigate the efficacy and safety o...
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Article
Open AccessStructural basis for neutralization of an anicteric hepatitis associated echovirus by a potent neutralizing antibody
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Article
Open AccessFast anther dehiscence status recognition system established by deep learning to screen heat tolerant cotton
From an economic perspective, cotton is one of the most important crops in the world. The fertility of male reproductive organs is a key determinant of cotton yield. Anther dehiscence or indehiscence directly ...
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Article
DLGAP1-AS2 promotes estrogen receptor signalling and confers tamoxifen resistance in breast cancer
Tamoxifen is a first-line endocrine agent and is often used to treat estrogen receptor-positive (ER+) breast cancer. Unfortunately, approximately 30-40% of patients who received tamoxifen therapy experience re...
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Article
Open AccessDeep learning approach for cancer subtype classification using high-dimensional gene expression data
Studies have shown that classifying cancer subtypes can provide valuable information for a range of cancer research, from aetiology and tumour biology to prognosis and personalized treatment. Current methods u...
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Article
Genome-wide association study of agronomic traits related to nitrogen use efficiency in wheat
GWAS identified 347 QTLs associated with eight traits related to nitrogen use efficiency in a 389-count wheat panel. Four novel candidate transcription factor genes were verified using qRT-PCR.
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Article
Open AccessTUBB2B facilitates progression of hepatocellular carcinoma by regulating cholesterol metabolism through targeting HNF4A/CYP27A1
Cholesterol metabolism plays a critical role in the progression of hepatocellular carcinoma (HCC), but it is not clear how cholesterol metabolism is regulated. The tubulin beta class I genes (TUBBs) are associ...
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Article
Open AccessForestSubtype: a cancer subtype identifying approach based on high-dimensional genomic data and a parallel random forest
Cancer subtype classification is helpful for personalized cancer treatment. Although, some approaches have been developed to classifying caner subtype based on high dimensional gene expression data, it is diff...
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Article
Sam68 promotes osteogenic differentiation of aortic valvular interstitial cells by TNF-α/STAT3/autophagy axis
Calcified aortic valve disease (CAVD) is a major non-rheumatic heart valve disease in the world, with a high mortality rate and without suitable pharmaceutical therapy due to its complex mechanisms. Src-associ...
