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Chapter and Conference Paper
Recommendation Algorithm Based on Product Category Path
In recent years, due to the rise of deep learning, most researchers are trying to combine the traditional recommendation system with deep learning, however the traditional recommendation model is still suitabl...
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Article
Automated assessment of BI-RADS categories for ultrasound images using multi-scale neural networks with an order-constrained loss function
Ultrasound imaging is one of the most frequently used diagnostic tools for detecting and analyzing abnormalities of the breast. Recently proposed methods for the automated analysis of breast ultrasound images ...
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Article
Open AccessRegulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain
3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is the rate-limiting enzyme in cholesterol synthesis and target of cholesterol-lowering statin drugs. Accumulation of sterols in endoplasmic reticulum (E...
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Article
Mechanisms and inhibition of Porcupine-mediated Wnt acylation
Wnt signalling is essential for regulation of embryonic development and adult tissue homeostasis1–3, and aberrant Wnt signalling is frequently associated with cancers4. Wnt signalling requires palmitoleoylation o...
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Protocol
Expression, Purification, and Structure Determination of Human PTCH1–HH-N Complexes
Patched-1 (PTCH1), a tumor suppressor, serves as the receptor of Hedgehog (HH) ligand and negatively regulates the HH signaling pathway. Mutations of PTCH1 are implicated in many human cancers. Structural inve...
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Article
Cancer‐associated fibroblasts secrete hypoxia‐induced serglycin to promote head and neck squamous cell carcinoma tumor cell growth in vitro and in vivo by activating the Wnt/β-catenin pathway
The tumor microenvironment (TME) is known to play a prominent role in the pathology of head and neck squamous cell carcinoma (HNSCC). Cancer-associated fibroblasts (CAFs) have been reported to regulate tumor p...
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Article
Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
Smoothened (SMO), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog signal across the cell membrane. Sterols can bind to its extracellular cysteine-rich domain (CRD) and to se...
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Article
Research on intelligent classification of multi-attribute safety information and determination of operating environment
To analyze the system safety through the field system operation data, especially the system operation information provided by the operators, and to obtain the environment scope of the safe operation of the sys...
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Article
Urban–Rural Differences in Bone Mineral Density and its Association with Reproductive and Menstrual Factors Among Older Women
This study aimed to compare the bone mineral density (BMD) of older women living in rural and urban areas, and evaluate the potential factors affecting the risk of osteoporosis.
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Article
Structure of nevanimibe-bound tetrameric human ACAT1
Cholesterol is an essential component of mammalian cell membranes, constituting up to 50% of plasma membrane lipids. By contrast, it accounts for only 5% of lipids in the endoplasmic reticulum (ER)1. The ER enzym...
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Article
Open AccessStructural basis for itraconazole-mediated NPC1 inhibition
Niemann-Pick C1 (NPC1), a lysosomal protein of 13 transmembrane helices (TMs) and three lumenal domains, exports low-density-lipoprotein (LDL)-derived cholesterol from lysosomes. TMs 3–7 of NPC1 comprise the S...
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Article
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi
The oncoprotein Smoothened (SMO), a G-protein-coupled receptor (GPCR) of the Frizzled-class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 (PTCH1) to the glioma-associated-oncog...
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Article
Structures of human Patched and its complex with native palmitoylated sonic hedgehog
Hedgehog (HH) signalling governs embryogenesis and adult tissue homeostasis in mammals and other multicellular organisms1–3. Whereas deficient HH signalling leads to birth defects, unrestrained HH signalling is i...
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Chapter
The Research on the Lung Tumor Imaging Based on the Electrical Impedance Tomography
Magnetic detection electrical impedance tomography (MD-EIT) can be used to reconstruct images of conductivity from magnetic field measurement taken around the body in vivo. To achieve the lung tumor imaging ba...
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Article
Structure and mechanism of a group-I cobalt energy coupling factor transporter
Energy-coupling factor (ECF) transporters are a large family of ATP-binding cassette transporters recently identified in microorganisms. Responsible for micronutrient uptake from the environment, ECF transport...
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Article
Open AccessPrognostic factors of palatal mucoepidermoid carcinoma: a retrospective analysis based on a double-center study
Mucoepidermoid carcinoma (MEC) of the palate is a common malignancy of minor salivary glands. This study was designed to identify the prognostic factors for MEC of the palate. The medical records of patients d...
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Article
Open AccessErratum: Metformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis
Scientific Reports 6: Article number: 35788; published online: 20 October 2016; updated: 24 February 2017 The original version of this Article contained a typographical error in the spelling of the author Weng...
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Article
Open AccessMetformin sensitizes the response of oral squamous cell carcinoma to cisplatin treatment through inhibition of NF-κB/HIF-1α signal axis
Resistance towards chemotherapy is a common complication in treatment of oral cancers, which leads to treatment failure and poor outcome. In recent years, a growing body of evidence has shown that tumour hypox...
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Chapter and Conference Paper
RLDRPSO: An Efficient Heuristic Algorithm for Task Partitioning
Task partitioning is the critical step in the co-design of reconfigurable embedded system. Particle Swarm Optimization (PSO) has been used for fast task partitioning. However, PSO has the problems of local ext...
