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    Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

    Smoothened (SMO), a class Frizzled G protein-coupled receptor (class F GPCR), transduces the Hedgehog signal across the cell membrane. Sterols can bind to its extracellular cysteine-rich domain (CRD) and to se...

    **aofeng Qi, Lucas Friedberg, Ryan De Bose-Boyd, Tao Long… in Nature Chemical Biology (2020)