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Article
Open AccessKAMPNet: multi-source medical knowledge augmented medication prediction network with multi-level graph contrastive learning
Predicting medications is a crucial task in intelligent healthcare systems, aiding doctors in making informed decisions based on electronic medical records (EMR). However, medication prediction faces challenge...
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Article
Open AccessReal-time detection of laryngopharyngeal cancer using an artificial intelligence-assisted system with multimodal data
Laryngopharyngeal cancer (LPC) includes laryngeal and hypopharyngeal cancer, whose early diagnosis can significantly improve the prognosis and quality of life of patients. Pathological biopsy of suspicious can...
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Article
Open AccessIntercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis
Gastric cancer (GC) is a fatal cancer with unclear pathogenesis. In this study, we explored the function and potential mechanisms of intercellular adhesion molecule 2 (ICAM2) in the development and advancement...
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Article
Open AccessLAD1 promotes malignant progression by diminishing ubiquitin-dependent degradation of vimentin in gastric cancer
Ladinin-1 (LAD1), an anchoring filament protein, has been associated with several cancer types, including cancers of the colon, lungs, and breast. However, it is still unclear how and why LAD1 causes gastric c...
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Article
New Fourier expansion for thermal buckling analysis of rectangular thin plates with various edge restraints
For the first time, a modified two-dimensional Fourier series approach is proposed for new thermal buckling analysis of rectangular thin plates under various edge conditions. The solution form of plate deflect...
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Article
Organotrifluoroborate enhances tumor targeting of fibroblast activation protein inhibitors for targeted radionuclide therapy
Fibroblast activation protein (FAP) is a pan-cancer target and now the state-of-the-art to develop radiopharmaceuticals. FAP inhibitors have been of great success in develo** imaging tracers. Yet, the overly...
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Article
Thermal buckling analysis of rotationally-restrained orthotropic thin plates utilizing a two-dimensional improved Fourier series approach
This study presents a first attempt in deriving new accurate analytical thermal buckling solutions of orthotropic thin plates through employing a modified two-dimensional Fourier series approach, with focus on...
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Chapter and Conference Paper
A Global View-Guided Autoregressive Residual Network for Irregular Time Series Classification
Irregularly sampled multivariate time series classification tasks become prevalent due to widespread application of sensors. However, different collection frequencies or sensor failures presents nontrivial cha...
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Article
ADAMTS10 inhibits aggressiveness via JAK/STAT/c-MYC pathway and reprograms macrophage to create an anti-malignant microenvironment in gastric cancer
A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10) plays a role in extracellular matrix and correlates with Weill–Marchesani syndrome. However, its role in gastric cancer remains unkn...
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Article
Open AccessSingle-shot compressed optical field topography
Femtosecond lasers are powerful in studying matter’s ultrafast dynamics within femtosecond to attosecond time scales. Drawing a three-dimensional (3D) topological map of the optical field of a femtosecond lase...
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Article
Integrative analysis of transcriptomic and proteomic changes related to male sterility in Tagetes erecta
Male sterile and male fertile two-type lines are important in heterosis utilization and breeding in Tagetes erecta, but the genes and pathways involved in male sterility are poorly understood. To explore these to...
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Article
Open AccessIdentification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer
Circular RNAs (circRNAs) are a novel class of noncoding RNAs. Increasing evidence indicates that circRNAs play an important role in the occurrence and development of tumors. However, the role of circRNA hsa_ci...
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Article
Open AccessThird or fourth branchial pouch sinus lesions: a case series and management algorithm
The purpose of this study was to develop an effective management algorithm for lesions of third or fourth branchial sinuses.
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Article
Effect of bottom slope on the nonlinear triad interactions in shallow water
This paper aims at investigating the effect of bottom slope to the nonlinear triad interactions for irregular waves propagating in shallow water. The physical experiments are conducted in a wave flume with res...
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Chapter and Conference Paper
Deep Sparse Informative Transfer SoftMax for Cross-Domain Image Classification
In many real applications, it is often encountered that the models trained on source domain cannot fit the related target images very well, due to the variants and changes of the imaging background, lighting o...
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Article
Practical inexact proximal quasi-Newton method with global complexity analysis
Recently several methods were proposed for sparse optimization which make careful use of second-order information (Hsieh et al. in Sparse inverse covariance matrix estimation using quadratic approximation. In:...
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Article
GJB2 and mitochondrial 12S rRNA susceptibility mutations in sudden deafness
Genetic susceptibility may play an important role in the pathogenesis of sudden deafness. However, the specific genes involved are largely unknown. We sought to explore the frequency of GJB2 and mitochondrial 12S...
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Article
Molecular cloning and expression analysis of mannose receptor in blunt snout bream (Megalobrama amblycephala)
Mannose receptor (MR) plays a significant role in innate immune responses to pathogens in vertebrates. Here we characterized the first teleost MR from Megalobrama amblycephala, named maMR and its expression patte...
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Article
Genetic diversity and structure of Lilium pumilum DC. in southeast of Qinghai–Tibet plateau
Lilium pumilum DC. is a valuable species not only for its showy flowers but also for its edible and medicinal values. As one of the distribution areas of L. pumilum, Qinghai–Tibet plateau has uni...
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Article
Open AccessDevelo** regional genetic counseling for southern Chinese with nonsyndromic hearing impairment: a unique mutational spectrum
Racial and regional factors are important for the clinical diagnosis of non-syndromic hearing impairment. Comprehensive genetic analysis of deaf patients in different regions of China must be performed to prov...
