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Open AccessCognition and attitudes of hospice care among healthcare providers: a case study of Sichuan Province
Under the background of the increasing aging population and cancer burden in China, the role of hospice care has become increasingly prominent. The government has paid more attention to the development of hosp...
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Open AccessA new method for the detection of Mycobacterium tuberculosis based on the CRISPR/Cas system
Mycobacterium tuberculosis (MTB) is a bacterium that can cause zoonoses by aerosol transmission. Tuberculosis (TB) caused by MTB heavily burdens world public health security. Develo** efficient, specific, conve...
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Open AccessApplication of platelet-rich plasma (PRP) in lips rejuvenation
In recent years, minimally invasive and non-invasive rejuvenation methods have been welcomed. PRP has been used widely for skin rejuvenation, but there are few studies on PRP for lip rejuvenation.
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Open AccessDevelopment of a nutritional risk screening tool for preterm children in outpatient settings during a complementary feeding period: a pilot study
A complementary feeding (CF) period is necessary for nutritional and developmental reasons. Preterm children encounter more feeding problems than their term counterparts in the CF period. The goal of this stud...
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Open AccessTranscriptomic comparison sheds new light on regulatory networks for dimorphic flower development in response to photoperiod in Viola prionantha
Chasmogamous (CH)–cleistogamous (CL) dimorphic flowers are developed in Viola prionantha. However, the environmental and genetic factors necessary for the CH–CL transition are unknown.
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Open AccessAutophagy facilitates age-related cell apoptosis—a new insight from senile cataract
Age-related cell loss underpins many senescence-associated diseases. Apoptosis of lens epithelial cells (LECs) is the important cellular basis of senile cataract resulted from prolonged exposure to oxidative s...
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Open AccessAtlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling
To gain mechanistic insights into the functions and developmental dynamics of tumor-infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA-sequencing and antigen receptor lineage a...
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Open AccessSingle-course antenatal corticosteroids is related to faster growth in very-low-birth-weight infant
Antenatal corticosteroids (ACS) treatment is critical to support survival and lung maturation in preterm infants, however, its effect on feeding and growth is unclear. Prior preterm delivery, it remains uncert...
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Open AccessThe PHOSPHATE1 genes participate in salt and Pi signaling pathways and play adaptive roles during soybean evolution
The PHOSPHATE1 (PHO1) gene family plays diverse roles in inorganic phosphate (Pi) transfer and signal transduction, and plant development. However, the functions and diversification of soybean PHO1 family are poo...
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Open AccessChinese lantern in Physalis is an advantageous morphological novelty and improves plant fitness
The origin of morphological novelties is an important but neglected issue of evolutionary biology. The fruit of the genus Physalis, a berry, is encapsulated by a novel morphological feature of the post-floral, ac...
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Open AccessExon junction complex (EJC) core genes play multiple developmental roles in Physalis floridana
Molecular and functional characterization of four gene families of the Physalis exon junction complex (EJC) core improved our understanding of the evolution and function of EJC core genes in plants.
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Open AccessCITED1 promotes proliferation of papillary thyroid cancer cells via the regulation of p21 and p27
It has been reported that CBP/p300-Interacting Transactivator with glutamic acid [E]/aspartic acid [D]-rich C-terminal domain 1 (CITED1) is overexpressed in papillary thyroid cancer (PTC). However, the functio...
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Open AccessExpression of B-class MADS-box genes in response to variations in photoperiod is associated with chasmogamous and cleistogamous flower development in Viola philippica
Some plants develop a breeding system that produces both chasmogamous (CH) and cleistogamous (CL) flowers. However, the underlying molecular mechanism remains elusive.
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Open AccessMolecular and geographic evolutionary support for the essential role of GIGANTEAa in soybean domestication of flowering time
Flowering time is a domestication trait of Glycine max and varies in soybeans, yet, a gene for flowering time variation has not been associated with soybean domestication. GIGANTEA (GI) is a major gene involved i...
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Open AccessSOX17 increases the cisplatin sensitivity of an endometrial cancer cell line
Endometrial cancer (EC) is the most common form of malignant gynecological tumor. Treatment with cisplatin (CDDP) is the mainstay of EC chemotherapy. The apoptotic machinery is regarded as an important etiolog...
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Erratum to: Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancer
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Open AccessStem cell protein Piwil1 endowed endometrial cancer cells with stem-like properties via inducing epithelial-mesenchymal transition
Stem cell protein Piwil1 functions as an oncogene in various tumor types. However, the exact function and mechanism of Piwil1 in endometrial cancer remains unclear.
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Open AccessSequence and expression variations suggest an adaptive role for the DA1-like gene family in the evolution of soybeans
The DA1 gene family is plant-specific and Arabidopsis DA1 regulates seed and organ size, but the functions in soybeans are unknown. The cultivated soybean (Glycine max) is believed to be domesticated from the ann...
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Open AccessSuppression of the epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1 signaling pathway in metastasis of endometrial cancer
Mechanisms governing the metastasis of endometrial cancer (EC) are poorly defined. Recent data support a role for Enhancer-of-split and hairy-related protein 1 (SHARP1), a basic helix-loop-helix transcription ...
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Open AccessFOXA1 promotes tumor cell proliferation through AR involving the Notch pathway in endometrial cancer
Increasing evidence suggests that forkhead box A1 (FOXA1) is frequently dysregulated in many types of human cancers. However, the exact function and mechanism of FOXA1 in human endometrial cancer (EC) remains ...