21 Result(s)
within
**ao-hui Liao
Science, Humanities and Social Sciences, multidisciplinary
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Article
Generation of functional thyroid from embryonic stem cells
The primary function of the thyroid gland is to metabolize iodide by synthesizing thyroid hormones, which are critical regulators of growth, development and metabolism in almost all tissues. So far, research o...
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Article
Open AccessLoss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy
To investigate whether altered energy metabolism induces the Warburg effect and results in tumor malignancy, the respiratory enzyme citrate synthase (CS) was examined, silenced and the effects analyzed. In hum...
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Open AccessRegulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection
T cell functional exhaustion during chronic hepatitis B virus (HBV) infection may contribute to the failed viral clearance; however, the underlying molecular mechanisms remain largely unknown. Here we demonstr...
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Open AccessIncreased RIPK4 expression is associated with progression and poor prognosis in cervical squamous cell carcinoma patients
Aberrant expression of receptor interacting protein kinase 4 (RIPK4), a crucial regulatory protein of Wnt/β-catenin signaling, has recently been reported to be involved in several cancers. Here, we report the ...
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Open AccessRisk Factors for Steatorrhea in Chronic Pancreatitis: A Cohort of 2,153 Patients
This study aimed to investigate the occurrence of and determine the risk factors for steatorrhea in chronic pancreatitis (CP). It was based on analysis of both retrospectively and prospectively acquired databa...
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Open AccessKIF2A regulates the spindle assembly and the metaphase I-anaphase I transition in mouse oocyte
KIF2A, a member of the kinesin-13 family, has been reported to play a role in spindle assembly in mitosis. However, its function in mammalian meiosis remains unknown. In this research, we examined the expressi...
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Open AccessSafety and Efficacy of a New Smartphone-controlled Vibrating Capsule on Defecation in Beagles
Constipation, mainly manifesting as abdominal discomfort and painful defecation, is considered as a chronic disorder. Due to a lack of effective therapy, it imposes a significant economic burden and greatly im...
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Open AccessConstruction of the REACHES climate database based on historical documents of China
This paper describes the methodology of an ongoing project of constructing an East Asian climate database REACHES based on Chinese historical documents. The record source is Compendium of Meteorological Records o...
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Open AccessA reporter mouse for non-invasive detection of toll-like receptor ligands induced acute phase responses
The acute phase response (APR) is a systemic first-line defense against challenges including infection, trauma, stress, and neoplasia. Alteration of acute phase protein (APP) levels in plasma is the most impor...
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Open AccessEnvironmental remodeling of human gut microbiota and antibiotic resistome in livestock farms
Anthropogenic environments have been implicated in enrichment and exchange of antibiotic resistance genes and bacteria. Here we study the impact of confined and controlled swine farm environments on temporal c...
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Open AccessImpact of cooking oil fume exposure and fume extractor use on lung cancer risk in non-smoking Han Chinese women
Smoking tobacco is the major risk factor for develo** lung cancer. However, most Han Chinese women with lung cancer are nonsmokers. Chinese cooking methods usually generate various carcinogens in fumes that ...
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Open AccessClassification of Early-Onset and Late-Onset Idiopathic Chronic Pancreatitis Needs Reconsideration
Bimodal classification of idiopathic chronic pancreatitis (ICP) into early-onset (<35 years) and late-onset (>35 years) ICP was proposed in 1994 based on a study of 66 patients. However, bimodal distribution w...
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Open AccessAn enzyme free fluorescence resonance transfer strategy based on hybrid chain reaction and triplex DNA for Vibrio parahaemolyticus
In this work, an enzyme-free fluorescence resonance energy transfer (FRET) strategy was established for rapid and specific detection of the DNA sequence from Vibrio parahaemolyticus (VP) using hybridization chain...
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Open AccessLarge-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting
Esophageal cancer (EC) is a type of aggressive cancer without clinically relevant molecular subtypes, hindering the development of effective strategies for treatment. To define molecular subtypes of EC, we per...
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Open AccessWAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour
The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake, also known as wake) modulates m...
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Open AccessClinical, laboratory characteristics and growth outcomes of children with growing pains
Growing pains (GP), a common and benign pain syndrome of unknown etiology, is characterized by bilateral recurrent leg pain in childhood. There are no standardized diagnostic criteria for GP, and the diagnosis...
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Article
Free-space dissemination of time and frequency with 10−19 instability over 113 km
Networks of optical clocks find applications in precise navigation1,2, in efforts to redefine the fundamental unit of the ‘second’3–6 and in gravitational tests7. As the frequency instability for state-of-the-art...
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Open AccessTransplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism
The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism...
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Open AccessThe mediating effects of personality traits on the relationship of youth conduct problems and mood disorders with adulthood suicidality
Identifying the relevant factors for suicidality in individuals with conduct problems is a public health concern, especially if they were under the influence of mood disorders later in life. This study investi...
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Open AccessMicrobes translocation from oral cavity to nasopharyngeal carcinoma in patients
The presence of oral microbes in extra-oral sites is linked to gastrointestinal cancers. However, their potential ectopically colonization in the nasopharynx and impact on local cancer development remains unce...
