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  1. Article

    Open Access

    Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

    The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism...

    Mírian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca in Nature Communications (2022)

  2. No Access

    Protocol

    Generation of Functional Thyroid Tissue Using 3D-Based Culture of Embryonic Stem Cells

    During the last decade three-dimensional (3D) cultures of pluripotent stem cells have been intensively used to understand morphogenesis and molecular signaling important for the embryonic development of many t...

    Francesco Antonica, Dominika Figini Kasprzyk, Andrea Alex Schiavo in Organ Regeneration (2017)

  3. No Access

    Article

    Generation of functional thyroid from embryonic stem cells

    The primary function of the thyroid gland is to metabolize iodide by synthesizing thyroid hormones, which are critical regulators of growth, development and metabolism in almost all tissues. So far, research o...

    Francesco Antonica, Dominika Figini Kasprzyk, Robert Opitz, Michelina Iacovino in Nature (2012)