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Open AccessEvaluation of a new high-throughput method for identifying quorum quenching bacteria
Quorum sensing (QS) is a population-dependent mechanism for bacteria to synchronize social behaviors such as secretion of virulence factors. The enzymatic interruption of QS, termed quorum quenching (QQ), has ...
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Article
Open AccessMaternal depressive symptoms related to Epstein-Barr virus reactivation in late pregnancy
We examined the relationship between maternal depressive symptoms in late pregnancy and Epstein-Barr virus reactivation before delivery. In this prospective observational study, prevalence of Epstein-Barr viru...
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Article
Open AccessLASSO NTCP predictors for the incidence of xerostomia in patients with head and neck squamous cell carcinoma and nasopharyngeal carcinoma
To predict the incidence of moderate-to-severe patient-reported xerostomia among head and neck squamous cell carcinoma (HNSCC) and nasopharyngeal carcinoma (NPC) patients treated with intensity-modulated radio...
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Article
Open AccessThe complex jujube genome provides insights into fruit tree biology
The jujube (Ziziphus jujuba Mill.), a member of family Rhamnaceae, is a major dry fruit and a traditional herbal medicine for more than one billion people. Here we present a high-quality sequence for the complex ...
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Open AccessChoice of Flap Affects Fistula Rate after Salvage Laryngopharyngectomy
Due to the significant morbidity and mortality associated with pharyngocutaneous fistula in pharyngoesophageal reconstruction following cancer resection, the purpose of this retrospective study is to examine t...
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Open AccessOocyte quality is decreased in women with minimal or mild endometriosis
Endometriosis, a pathological condition in which the endometrium grows outside the uterus, is one of the most common causes of female infertility; it is diagnosed in 25–40% of infertile women. The mechanism by...
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Article
Open AccessTandem C–H oxidation/cyclization/rearrangement and its application to asymmetric syntheses of (−)-brussonol and (−)-przewalskine E
Natural products are a vital source of lead compounds in drug discovery. Development of efficient tandem reactions to build useful compounds and apply them to the synthesis of natural products is not only a si...
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Open AccessGreater serum carotenoid levels associated with lower prevalence of nonalcoholic fatty liver disease in Chinese adults
Previous studies have suggested that serum carotenoids may be inversely associated with liver injury, but limited data are available from population-based studies. We examined the relationship between serum ca...
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Open AccessGossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites
Of the two cultivated species of allopolyploid cotton, Gossypium barbadense produces extra-long fibers for the production of superior textiles. We sequenced its genome (AD)2 and performed a comparative analysis. ...
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Article
Open AccessEstrogen ameliorates microglial activation by inhibiting the Kir2.1 inward-rectifier K+ channel
Microglial activation is implicated in the pathogenesis of Parkinson’s disease (PD). Although the etiology of PD remains unclear, age and male gender are known PD risk factors. By comparing microglia and dopam...
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Article
Open AccessSpatial organization of heterologous metabolic system in vivo based on TALE
For years, prokaryotic hosts have been widely applied in bio-engineering. However, the confined in vivo enzyme clustering of heterologous metabolic pathways in these organisms often results in low local concentra...
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Open AccessDifferential effects of conifer and broadleaf litter inputs on soil organic carbon chemical composition through altered soil microbial community composition
A strategic selection of tree species will shift the type and quality of litter input and subsequently magnitude and composition of the soil organic carbon (SOC) through soil microbial community. We conducted ...
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Article
Open AccessExogenous N addition enhances the responses of gross primary productivity to individual precipitation events in a temperate grassland
Predicted future shifts in the magnitude and frequency (larger but fewer) of precipitation events and enhanced nitrogen (N) deposition may interact to affect grassland productivity, but the effects of N enrich...
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Open AccessErratum: Spatial organization of heterologous metabolic system in vivo based on TALE
Scientific Reports 6: Article number: 26065; published online: 17 May 2016; updated: 10 June 2016. The original HTML version of this Article contained typographical errors in the spelling of the author Lv-yun ...
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Open AccessA newly discovered member of the Atlastin family, BmAtlastin-n, has an antiviral effect against BmNPV in Bombyx mori
Atlastin is a member of the dynamin protein superfamily and it can mediate homotypic fusion of endoplasmic reticulum (ER) membranes, which is required for many biological processes. In this study, a new Atlast...
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Open AccessSurface expression of hippocampal NMDA GluN2B receptors regulated by fear conditioning determines its contribution to memory consolidation in adult rats
The number and subtype composition of N-methyl-d-aspartate receptor (NMDAR) at synapses determines their functional properties and role in learning and memory. Genetically increased or decreased amount of GluN...
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Open AccessAssessing bleeding risk in 4824 Asian patients with atrial fibrillation: The Bei**g PLA Hospital Atrial Fibrillation Project
The risks of major bleeding and intracranial hemorrhage (ICH) are higher in Asian patients with atrial fibrillation (AF) compared to non-Asians. We aimed to investigate risk factors for bleeding and validate t...
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Open AccessKeratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination
Toll-like receptors (TLRs) have critical roles in innate immunity and inflammation and the detailed mechanisms by which TLR signaling is fine tuned remain unclear. Keratin 8 (CK8) belongs to the type II kerati...
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Open AccessPotentials of the elevated circulating miR-185 level as a biomarker for early diagnosis of HBV-related liver fibrosis
Early diagnosis of liver fibrosis is critical for early intervention and prognosis of various chronic liver diseases. Conventional repeated histological assessment is impractical due to the associated invasive...
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Open AccessLosartan reduces ensuing chronic kidney disease and mortality after acute kidney injury
Acute kidney injury (AKI) is an important risk factor for incident chronic kidney disease (CKD). Clinical studies disclose that ensuing CKD progresses after functional recovery from AKI, but the underlying mec...