726 Result(s)
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Chapter
Almost Sure Convergence of Some Approximate Solutions for Random Parabolic Equations
The paper is concerned with some approximate solutions for random partial differential equations of parabolic type via discretization in time or by an eigenfunction expansion. In contrast with L ...
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Article
A huntingtin-associated protein enriched in brain with implications for pathology
HUNTINGTON's disease (HD) is an autosomal dominant neuro-degenerative disorder caused by an expanding polyglutamine repeat in the IT 15 or huntingtin gene1. Although this gene is widely expressed2–9 and is requir...
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Article
Large boron isotopic fractionation during magmatic-hydrothermal processes in the Lavicky leucocratic two-mica granite, Czech Republic
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Article
Controls on boron isotopic fractionation of tourmaline in magmatic and submarine hydrothermal ore-forming systems
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Article
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
Huntington's disease is an autosomal-dominant progressive neurodegenerative disorder resulting in specific neuronal loss and dysfunction in the striatum and cortex1. The disease is universally fatal, with a mean ...
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Article
Call in question and discussion: Are there sandwiched low-grade metamorphic slabs within UHP metamorphic rocks in the Dabieshan terrane?
Some geologists reported their discovery of sandwiched low-grade metamorphic slabs within UHP metamorphic Complexes in Changpu, Yuexi County, Anhui Province. They also suggested that some coesite-bearing eclog...
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Article
Identification of receptors for neuromedin U and its role in feeding
Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was isolated first from porcine spinal cord and later from other species1,2,3,4,5,6,7,8. It is widely distributed in the gut and ce...
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Article
Flexible style that encourages outcrossing
Despite the convenience of self-pollination (selfing) in flowering plants 1,2,3, the detrimental effects of inbreeding that follow repeated selfing3,4 have promoted strong natural selection for mating systems tha...
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Article
The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors
Migration is a basic feature of many cell types in a wide range of species1. Since the 1800s, cell migration has been proposed to occur in the nervous and immune systems2,3, and distinct molecular cues for mammal...
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Article
Study of a new ytterbium doped phosphate laser glass
Physical, and spectral properties of a new commercial ytterbium doped phosphate laser glass with big size, NEW/Yb, was researched. Assessing from thermal mechanical property, nonlinear property, crystalline ph...
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Article
Open AccessUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pul...
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Article
Role of ran GTPase in cell cycle regulation
Ran, a member of the Ras GTPase superfamily, is a multifunctional protein and abundant in the nucleus. Many evidences suggest that Ran and its interacting proteins are involved in multiple aspects of the cell ...
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Article
U-Pb dating of zircons from quartz diorite and its enclaves at Tongguanshan in Anhui and its petrogenetic implication
The genesis of intermediate-silicic intrusive rocks and their enclaves in Tongling are closely related to Fe, Cu mineralization, which may provide petrologic information on lithospheric dynamics in this region...
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Article
Effect of alkali metal oxides on upconversion fluorescence properties of germanate-tellurite glasses
Upconversion emissions of Yb3+/Er3+-codoped germanate-tellurite glasses have been investigated upon the excitation of 980 nm laser diode (LD). It is found that upconversion luminescence intensities significantly ...
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Article
SHRIMP U-Pb zircon dating for lamprophyre from Liaodong Peninsula: Constraints on the initial time of Mesozoic lithosphere thinning beneath eastern China
It is undebated fact that the lithospheric mantle beneath eastern China was considerably thinned during the Mesozoic time. However, it has no adequate evidence for the exact timing when the lithosphere thinnin...
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Article
In situ observation of C60(C(COOH)2)2 interacting with living cells using fluorescence microscopy
The interactions between nanoparticles and living cells were investigated by an imaging technique of fluorescence microscopy. For this purpose, the C60 derivative C60(C(COOH)2)2, a therapeutic agent for degenerat...
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Article
LOH on chromosome 11q, but not SDHD and men1 mutations was frequently detectable in chinese patients with pheochromocytoma and paraganglioma
Recently, the succinate dehydrogenase subunit D (SDHD) gene has been reported as one of the major susceptibility genes for pheochromocytoma (PCC) and paraganglioma (PGL). In addition, loss of heterozygosity (LOH)...
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Article
99mTc-HYNIC-TOC scintigraphy in evaluation of active Graves’ ophthalmopathy (GO)
A promising radiopharmaceutical 99mTc-HYNIC-TOC (99mTc-HYNIC-Octreotide) can be applied for somatostatin receptor scintigraphy with the potential to replace Indium-111 labeled somatostatin analogus. Here we evalu...
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Article
The A946T polymorphism in the interferon induced helicase gene does not confer susceptibility to Graves’ disease in Chinese population
Genetic susceptibility plays a major role in the etiology of Graves’ disease (GD). A recent study revealed that the A946T polymorphism (rs1990760) in interferon induced helicase (IFIH1) gene was a susceptible ...
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Article
Towards a transgenic model of Huntington’s disease in a non-human primate
Huntington's disease is a severely disabling and lethal neurodegenerative disorder. The development of a non-human primate model for the disease would be invaluable in understanding its pathology and in develo...