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  1. No Access

    Article

    Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

    Genetic1,2,3,4,5,6,7,8 and pharmacological6,9,10,11,12 studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological function of Mc3r, a melanocorti...

    Airu S. Chen, Donald J. Marsh, Myrna E. Trumbauer, Easter G. Frazier… in Nature Genetics (2000)

  2. No Access

    Article

    Identification of receptors for neuromedin U and its role in feeding

    Neuromedin U (NMU) is a neuropeptide with potent activity on smooth muscle which was isolated first from porcine spinal cord and later from other species1,2,3,4,5,6,7,8. It is widely distributed in the gut and ce...

    Andrew D. Howard, Rui** Wang, Sheng-Shung Pong, Theodore N. Mellin… in Nature (2000)

  3. No Access

    Article

    Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

    We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cy...

    Airu S. Chen, Joseph M. Metzger, Myrna E. Trumbauer, **ao-ming Guan… in Transgenic Research (2000)