209 Result(s)
within
**ang-Long Wang
Biomedicine
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Article
Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating
By defining the functional defect in a congenital myasthenic syndrome (CMS), we show that the third transmembrane domain (M3) of the muscle acetylcholine receptor governs the speed and efficiency of gating of ...
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Article
Age-associated changes of superoxide dismutase and catalase activities in the rat brain
Oxygen free radicals have been proposed to be involved in the process of aging. Superoxide dismutase (SOD) and catalase are important for antioxidative defense. In this study, profiles of SOD, catalase, and th...
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Article
The Heterogeneity in Risk Factors of Lung Cancer and the Difference of Histologic Distribution between Genders in Taiwan
Objective: The difference in histologic patterns of lung cancer between men and women in Taiwan may be associated with the heterogeneity in causal factors of lung cancer between the sexes. Methods: Cases consist...
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Article
Effect of the neuroprotective agent riluzole on intracellular Ca2+ levels in IMR32 neuroblastoma cells
Riluzole is an effective neuroprotective drug. Its effect on intracellular free Ca2+ levels ([Ca2+]i) has not been explored. This study examined the effect of riluzole on [Ca2+]i in IMR32 neuroblastoma cells usi...
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Article
Combined IL-12 and GM-CSF gene therapy for murine hepatocellular carcinoma
Among various immunotherapeutic approaches, interleukin-12 (IL-12) is particularly appealing because of its superior antitumor effects, which have been demonstrated in preclinical as well as clinical studies. ...
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Article
Predicting hepatitis B virus–positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies. Its high mortality rate is mainly a result of intra-hepatic metastases. We analyzed the expression profiles of HCC sa...
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Article
Schistosoma japonicum migration through mouse skin compared histologically and immunologically with S. mansoni
The migration of Schistosoma japonicum and S. mansoni through mouse skin epidermis and dermis was compared by immunofluorescence techniques from 4 to 22 h after infection. At all times, the percentage of parasite...
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Article
Genetic Diversity and Population Differentiation of the Dominant Species Stipa krylovii in the Inner Mongolia Steppe
Random amplified polymorphic DNA was used to assess the level of genetic diversity and genetic structure of Stipa krylovii (Gramineae), an important dominant species in the northern grasslands of China. Genetic d...
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Article
The functional motif of SARS-CoV S protein involved in the interaction with ACE2
SARS-CoV is a newly discovery pathogen causing severe acute respiratory problems. It has been established that the S protein in this pathogen plays an important rule in the adsorption and penetration of SARS-C...
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Article
A primary study of the subgroups of T lymphocytes in MHV-3 induced chronic viral hepatitis
To study the contribution of T cell subsets in the pathogenesis of Murine hepatitis virus Type 3 (MHV-3) induced chronic viral hepatitis in C3H/Hej mice, ninety C3H/Hej mice were chosen to individually receive...
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Article
Open AccessIn silico analysis and verification of S100 gene expression in gastric cancer
The S100 protein family comprises 22 members whose protein sequences encompass at least one EF-hand Ca2+ binding motif. They were involved in the regulation of a number of cellular processes such as cell cycle pr...
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Article
Schistosoma japonicum infection modulates the development of allergen-induced airway inflammation in mice
Asthma, a chronic inflammatory disorder of the airways, is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. It has been shown that helminth infections including Schistosoma ...
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Article
Variation of 423G>T in the Agouti Gene Exon 4 in Indigenous Chinese Goat Breeds
The Agouti gene plays an important role in pigment synthesis in domestic animals. A transversion of 423G>T recognized by BanII was found after a fragment (178 bp) of the goat Agouti gene exon 4 was amplified and ...
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Article
Immunologic Analysis of HIV-Uninfected Taiwanese Children with BCG-Induced Disease
The aim of this study was to evaluate immunity in HIV-uninfected children with bacille Calmette–Guerin-induced disease (BCG-ID) over an 8-year period, with particular emphasis on underlying diseases.
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Article
Open AccessInhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin
Angiogenesis plays an important role in the development and progression of tumors. Kallistatin exerts anti-angiogenic and anti-inflammatory activities that may be effective in inhibiting tumor metastasis. We i...
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Article
Neuroprotective Effect of Lipoxin A4 Methyl Ester in a Rat Model of Permanent Focal Cerebral Ischemia
Neuroprotective effect of lipoxin A4 methyl ester (LXA4 ME) was tested in a rat model of permanent middle cerebral artery occlusion. LXA4 ME was administrated through intracerebroventricular injection immediately...
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Article
HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats
To improve and validate analytical methods based on HPLC and liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) for the quantitative measurement of sinomenine in r...
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Article
Open AccessEndotoxin and CD14 in the progression of biliary atresia
Biliary atresia (BA) is a typical cholestatic neonatal disease, characterized by obliteration of intra- and/or extra-hepatic bile ducts. However, the mechanisms contributing to the pathogenesis of BA remain un...
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Article
Effect of CD4+CD25+ regulatory T cells on the immune evasion of Schistosoma japonicum
It has been known that parasites developed sophisticated strategies to escape from the host immune assault. More recently, one strategy to induce immune evasion involved CD4+CD25+ regulatory T cells (Tregs). Mice...
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Article
Cerebellar Long-term Depression is Deficient in Niemann–Pick Type C Disease Mice
Niemann–Pick type C disease (NPC) is an autosomal recessive lipidosis characterized by progressive neurodegeneration. Although several studies have revealed unusual accumulation of unesterfied cholesterol in a...
