Abstract
It has been known that parasites developed sophisticated strategies to escape from the host immune assault. More recently, one strategy to induce immune evasion involved CD4+CD25+ regulatory T cells (Tregs). Mice were infected with Schistosoma japonicum cercariae and then injected intraperitoneally with anti-CD25 monoclonal antibody (anti-CD25 mAb). The results showed that the percentages of CD4+CD25+ Tregs in mice were expanded by S. japonicum infection, and it could be partially blocked by anti-CD25 mAb. Worm burden in anti-CD25 mAb group (23.17 ± 6.94) was significantly lower than that in infected group (30.17 ± 5.85). The level of interferon gamma was increased with anti-CD25 mAb administration; meanwhile, lower concentration of interleukin 10 was observed in the same group. These results suggest that CD4+CD25+ Tregs contribute to the escape of S. japonicum from the host immune responses, while anti-CD25 mAb can partially block CD4+CD25+ Tregs and enhance the protective immunity to the parasite by Th1-type immune response.
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References
Curotto de Lafaille MA, Lafaille JJ (2009) Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity 30:626–635
Hisaeda H, Maekawa Y, Iwakawa D, Okada H, Himeno K, Kishihara K, Tsukumo S, Yasutomo K (2004) Escape of malaria parasites from host immunity requires CD4+ CD25+ regulatory T cells. Nat Med 10:29–30
Hoffmann KF, James SL, Cheever AW, Wynn TA (1999) Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. J Immunol 163:927–938
Jonuleit H, Schmitt E (2003) The regulatory T cell family: distinct subsets and their interrelations. J Immunol 171:6323–6327
Kursar M, Bonhagen K, Fensterle J, Köhler A, Hurwitz R, Kamradt T, Kaufmann SH, Mittrücker HW (2002) Regulatory CD4 + CD25+ T cells restrict memory CD8+ T cell responses. J Exp Med 196:1585–1592
Liu F, Hu W, Cui SJ, Chi M, Fang CY, Wang ZQ, Yang PY, Han ZG (2007) Insight into the host–parasite interplay by proteomic study of host proteins copurified with the human parasite, Schistosoma japonicum. Proteomics 7:450–462
Mariano FS, Gutierrez FR, Pavanelli WR, Milanezi CM, Cavassani KA, Moreira AP, Ferreira BR, Cunha FQ, Cardoso CR, Silva JS (2008) The involvement of CD4+CD25+ T cells in the acute phase of Trypanosoma cruzi infection. Microbes Infect 10:825–833
Mills KH (2004) Regulatory T cells: friend or foe in immunity to infection? Nat Rev Immunol 4:841–855
Mo HM, Liu WQ, Lei JH, Cheng YL, Wang CZ, Li YL (2007) Schistosoma japonicum eggs modulate the activity of CD4+CD25+ Tregs and prevent development of colitis in mice. Exp Parasitol 116:385–389
Nakamura K, Kitani A, Strober W (2001) Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med 194:629–644
Ruppel A, Shi YE, Moloney NA (1990) Schistosoma mansoni and S. japonicum: comparison of levels of ultraviolet irradiation for vaccination of mice with cercariae. Parasitology 101:23–26
Sacks D, Sher A (2002) Evasion of innate immunity by parasitic protozoa. Nat Immunol 3:1041–1407
Suri-Payer E, Amar AZ, Thornton AM, Shevach EM (1998) CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. J Immunol 160:1212–1218
Wan YY, Flavell RA (2007) Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445:766–770
Wei G, Tabel H (2008) Regulatory T cells prevent control of experimental African trypanosomiasis. J Immunol 180:2514–2521
Yurchenko E, Tritt M, Hay V, Shevach EM, Belkaid Y, Piccirillo CA (2006) CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med 203:2451–2460
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This work was funded by the National Natural Foundation of China (project grant 30771884). This research was performed in compliance with the laws of China and the authors’ respective institutions.
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Tang, Cl., Lei, Jh., Wang, T. et al. Effect of CD4+CD25+ regulatory T cells on the immune evasion of Schistosoma japonicum . Parasitol Res 108, 477–480 (2011). https://doi.org/10.1007/s00436-010-2089-2
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DOI: https://doi.org/10.1007/s00436-010-2089-2