65 Result(s)

Article

Selective deletion of E3 ubiquitin ligase FBW7 in VE-cadherin-positive cells instigates diffuse large B-cell lymphoma in mice in vivo

During the maturation of hematopoietic stem/progenitor cells (HSPCs) to fully differentiated mature B lymphocytes, develo** lymphocytes may undergo malignant transformation and produce B-cell lymphomas. Emer...

Zhaohua Cai, Shao** You, Zhixue Liu, ** Song, Fujie Zhao… in Cell Death & Disease (2024)

Article

HMGA1 drives chemoresistance in esophageal squamous cell carcinoma by suppressing ferroptosis

Chemotherapy is a primary treatment for esophageal squamous cell carcinoma (ESCC). Resistance to chemotherapeutic drugs is an important hurdle to effective treatment. Understanding the mechanisms underlying ch...

**g-Yu Yang, **n-Yuan Lei, Kai-Yue He, **-Rong Guo, Meng-Jie Liu… in Cell Death & Disease (2024)

Article

Retraction Note: Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway

**-Feng Zhu, Yi Liu, Wen-Ting Li, Ming-Hui Li, Chao-Hui Zhen… in Cell Death & Disease (2024)

Article

BRISC is required for optimal activation of NF-κB in Kupffer cells induced by LPS and contributes to acute liver injury

BRISC (BRCC3 isopeptidase complex) is a deubiquitinating enzyme that has been linked with inflammatory processes, but its role in liver diseases and the underlying mechanism are unknown. Here, we investigated ...

Wen Zhang, Kai Liu, Guang-Ming Ren, Yu Wang, Ting Wang, **an Liu… in Cell Death & Disease (2023)

Article

Neuron-secreted NLGN3 ameliorates ischemic brain injury via activating Gαi1/3-Akt signaling

We here tested the potential activity and the underlying mechanisms of neuroligin-3 (NLGN3) against ischemia-reperfusion-induced neuronal cell injury. In SH-SY5Y neuronal cells and primary murine cortical neur...

Zhi-guo Chen, **n Shi, **an-xian Zhang, Fang-Fang Yang, Ke-ran Li… in Cell Death & Disease (2023)

Article

IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m⁶A-dependent manner

Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the exact molecular mechanisms of IGF2BP3 in colorectal cancer ...

Li-Jie Chen, Hui-Ye Liu, Zhi-Yuan **ao, Ting Qiu, Dan Zhang… in Cell Death & Disease (2023)

Article

NPM promotes hepatotoxin-induced fibrosis by inhibiting ROS-induced apoptosis of hepatic stellate cells and upregulating lncMIAT-induced TGF-β2

Liver fibrosis is caused by a variety of chronic liver injuries and has caused significant morbidity and mortality in the world with increasing tendency. Elucidation of the molecular mechanism of liver fibrosi...

Xue Ding, **n-Le Zhu, Dong-Hui Xu, Shuang Li, Qiong Yang, **an Feng… in Cell Death & Disease (2023)

Article

RETRACTED ARTICLE: Ibrutinib facilitates the sensitivity of colorectal cancer cells to ferroptosis through BTK/NRF2 pathway

Ibrutinib is a drug that inhibits the protein Burton’s tyrosine kinase and thereby the nuclear translocation of Nrf2, which played a key role in mediating the activation of antioxidants during stress condition...

**-Feng Zhu, Yi Liu, Wen-Ting Li, Ming-Hui Li, Chao-Hui Zhen… in Cell Death & Disease (2023)

Article

m⁵C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating RABL6/TK1 mRNAs splicing and stabilization

The significance of 5-methylcytosine (m⁵C) methylation in human malignancies has become an increasing focus of investigation. Here, we show that m⁵C regulators including writers, readers and erasers, are predomin...

Ning Wang, Ri-xin Chen, Min-hua Deng, Wen-su Wei, Zhao-hui Zhou… in Cell Death & Disease (2023)

Article

HN1L/AP-2γ/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma

Hematological and neurological expressed 1 like (HN1L) is a newly identified oncogene in lung cancer and hepatocellular carcinoma recently identified by our team, but its roles in the development and treatment...

Ting-Ting Zeng, Tian-Hao Deng, Zhen Liu, Jia-Rong Zhan… in Cell Death & Disease (2022)

Article

Correction: Mutated lncRNA increase the risk of type 2 diabetes by promoting β cell dysfunction and insulin resistance

Wan-Hui Guo, Qi Guo, Ya-Lin Liu, Dan-Dan Yan, Li **, Rong Zhang… in Cell Death & Disease (2022)

Article

BNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia

Mitophagy is an important metabolic mechanism that modulates mitochondrial quality and quantity by selectively removing damaged or unwanted mitochondria. BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting p...

Yun-Ling He, Jian Li, Sheng-Hui Gong, **ang Cheng, Ming Zhao… in Cell Death & Disease (2022)

Article

PA-MSHA induces inflamed tumor microenvironment and sensitizes tumor to anti-PD-1 therapy

A low response rate to immune checkpoint inhibitor (ICI) therapy has impeded its clinical use. As reported previously, an inflamed tumor microenvironment (TME) was directly correlated with patients’ response t...

Min Huang, Fang He, Dan Li, Ya-Jia **e, Ze-Bo Jiang, Ju-Min Huang… in Cell Death & Disease (2022)

Article

Mutated lncRNA increase the risk of type 2 diabetes by promoting β cell dysfunction and insulin resistance

Islet β cell dysfunction and insulin resistance are the main pathogenesis of type 2 diabetes (T2D), but the mechanism remains unclear. Here we identify a rs3819316 C > T mutation in lncRNA Reg1cp mainly expressed...

Wan-Hui Guo, Qi Guo, Ya-Lin Liu, Dan-Dan Yan, Li **, Rong Zhang… in Cell Death & Disease (2022)

Article

HDAC6-dependent deacetylation of TAK1 enhances sIL-6R release to promote macrophage M2 polarization in colon cancer

Histone deacetylase 6 (HDAC6), a member of the HDAC family, has been identified as a potential therapeutic target for tumor therapy, but the function and underlying mechanisms of HDAC6 in colon cancer are inco...

Guangying Xu, Liling Niu, Youhui Wang, Guang Yang, **ngwu Zhu… in Cell Death & Disease (2022)

Article

The crosstalk between endothelial cells and vascular smooth muscle cells aggravates high phosphorus-induced arterial calcification

Arterial calcification is highly prevalent, particularly in patients with end-stage renal disease (ESRD). The osteogenic differentiation of vascular smooth muscle cells (VSMCs) is the critical process for the ...

**ao Lin, Su-Kang Shan, Feng Xu, Jia-Yu Zhong, Feng Wu… in Cell Death & Disease (2022)

Article

Correction to: NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease

**ao-fei He, **g-hui Xu, Ge Li, Ming-yue Li, Li-li Li, Zhong Pei… in Cell Death & Disease (2022)

Article

Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury

Ischemia-induced neuronal death leads to serious lifelong neurological deficits in ischemic stroke patients. Histone deacetylase 6 (HDAC6) is a promising target for neuroprotection in many neurological disorde...

**-**a Hu, Wei-**g Ma, Li-Ying He, Cong-Hui Zhang, Cheng Zhang… in Cell Death & Disease (2022)