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Article
Filial Piety and the Development of Independence and Interdependence During Emerging Adulthood: A Longitudinal Study of Taiwanese Adolescents
While filial piety has been widely studied in Confucian-influenced societies, little is known about how it may influence the development of emerging adults’ independence and interdependence. Using a population...
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Article
ABCC4 suppresses glioblastoma progression and recurrence by restraining cGMP-PKG signalling
Cyclic nucleotides are critical mediators of cellular signalling in glioblastoma. However, the clinical relevance and mechanisms of regulating cyclic nucleotides in glioblastoma progression and recurrence have...
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Article
Open AccessHuman biodistribution and radiation dosimetry for the tau tracer [18F]Florzolotau in healthy subjects
Tau pathology plays a crucial role in neurodegeneration diseases including Alzheimer’s disease (AD) and non-AD diseases such as progressive supranuclear palsy. Tau positron emission tomography (PET) is an in-v...
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Article
Open AccessIncreased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters
DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are “non-atopic”, lacking a clear etiology.
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Article
Towards High-Performance Graph Processing: From a Hardware/Software Co-Design Perspective
Graph processing has been widely used in many scenarios, from scientific computing to artificial intelligence. Graph processing exhibits irregular computational parallelism and random memory accesses, unlike t...
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Article
Prevalent landscape of tumor genomic alterations of luminal B1 breast cancers using a comprehensive genomic profiling assay in Taiwan
The human epidermal growth factor receptor 2 (HER2) negative luminal B1 subtype of breast cancer has been reported with a poorer outcome than luminal A in recent studies. This study aimed to investigate the mo...
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Article
Open AccessNovel lissencephaly-associated NDEL1 variant reveals distinct roles of NDE1 and NDEL1 in nucleokinesis and human cortical malformations
The development of the cerebral cortex involves a series of dynamic events, including cell proliferation and migration, which rely on the motor protein dynein and its regulators NDE1 and NDEL1. While the loss ...
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Article
Synthesis and Characterization of Two Functional Complexes Based on 2-Methyldipyrido[3,2-f:2′,3′-h]quinoxaline as Co-catalysts and Their Enhancement on Photocatalytic H2 Production Activity of g-C3N4
Hydrogen as a new energy source, it can be made by photocatalytic technology. However, the photocatalyst is the key to the efficient decomposition of water to produce hydrogen. Functional complexes are porous ...
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Article
Open AccessNav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis
Osteoarthritis (OA) is the most common joint disease. Currently there are no effective methods that simultaneously prevent joint degeneration and reduce pain1. Although limited evidence suggests the existence of ...
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Article
Comparison of 16S rRNA gene sequencing microbiota among children with serological IgE-mediated food hypersensitivity
We hypothesized that specific food hypersensitivity (FH) in children is linked to specific gut microbiota. The aim of our study was to quantify and evaluate differences in gut microbial composition among child...
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Article
Open AccessPrevalence of BRCA1, BRCA2, and PALB2 genomic alterations among 924 Taiwanese breast cancer assays with tumor-only targeted sequencing: extended data analysis from the VGH-TAYLOR study
The homologous recombination (HR) repair pathway for DNA damage, particularly the BRCA1 and BRCA2 genes, has become a target for cancer therapy, with poly ADP-ribose polymerase (PARP) inhibitors showing significa...
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Article
Advances in Studies of Chiglitazar Sodium, a Novel PPAR Pan-Agonist, for the Treatment of Type 2 Diabetes Mellitus
Chiglitazar sodium is a new peroxisome proliferator-activated receptor (PPAR) pan-agonist with independent intellectual property rights in China. It can treat type 2 diabetes mellitus and regulate metabolism b...
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Article
Clinical characteristics and treatment outcomes of invasive ductal and lobular carcinoma: analyses of 54,832 taiwan cancer registry index cases
Invasive lobular cancer (ILC) is the second most common histology type of breast cancer followed by invasive ductal carcinoma (IDC). This study aimed to investigate the characteristic, treatment strategies, an...
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Article
Open AccessKnockdown of Porf-2 restores visual function after optic nerve crush injury
Retinal ganglion cells (RGCs), the sole output neurons in the eyes, are vulnerable to diverse insults in many pathological conditions, which can lead to permanent vision dysfunction. However, the molecular and...
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Article
Open AccessElevated glutamate impedes anti-HIV-1 CD8 + T cell responses in HIV-1-infected individuals on antiretroviral therapy
CD8 + T cells are essential for long-lasting HIV-1 control and have been harnessed to develop therapeutic and preventive approaches for people living with HIV-1 (PLWH). HIV-1 infection induces marked metabolic...
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Article
Open AccessSpatiotemporal control of genome engineering in cone photoreceptors
Cones are essential for color recognition, high resolution, and central vision; therefore cone death causes blindness. Understanding the pathophysiology of each cell type in the retina is key to develo** the...
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Article
Open AccessApplication of platelet-rich plasma (PRP) in lips rejuvenation
In recent years, minimally invasive and non-invasive rejuvenation methods have been welcomed. PRP has been used widely for skin rejuvenation, but there are few studies on PRP for lip rejuvenation.
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Article
Open AccessCharacteristics of breast cancers detected by screening mammography in Taiwan: a single institute’s experience
Breast cancer is the most common female malignancy in the world. Nearly ninety percent of screening-detected breast cancers were diagnosed with earlier stages of 0 to II in Taiwan. It’s widely acknowledged tha...
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Article
Open AccessComparison of outcomes of proximal versus distal and combined splenic artery embolization in the management of blunt splenic injury: a report of 202 cases from a single trauma center
To compare the outcomes of blunt splenic injuries (BSI) managed with proximal (P) versus distal (D) versus combined (C) splenic artery embolization (SAE).
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Article
Open AccessComparison of the effect of 360° versus two-dimensional virtual reality video on history taking and physical examination skills learning among undergraduate medical students: a randomized controlled trial
Before caring for patients, video instruction is commonly used for undergraduate medical students, and 360° virtual reality (VR) videos have gained increasing interest in clinical medical education. Therefore,...
