8 Result(s)

Article

Asparagus officinalis combined with paclitaxel exhibited synergistic anti-tumor activity in paclitaxel-sensitive and -resistant ovarian cancer cells

Although paclitaxel is a promising first-line chemotherapeutic drug for ovarian cancer, acquired resistance to paclitaxel is one of the leading causes of treatment failure, limiting its clinical application. Aspa...

**n Zhang, Jiandong Wang, Yali Fan… in Journal of Cancer Research and Clinical On… (2023)

Article

Correction to: BAHD1 serves as a critical regulator of breast cancer cell proliferation and invasion

Ze-yu Yang, Su-peng Yin, Qingnan Ren, Deng-wei Lu, Tao Tang, Yao Li… in Breast Cancer (2022)

Article

Camrelizumab combined with apatinib and S-1 as second-line treatment for patients with advanced gastric or gastroesophageal junction adenocarcinoma: a phase 2, single-arm, prospective study

The current second-line treatment of advanced gastric or gastroesophageal junction adenocarcinoma remains unsatisfactory. Anti-PD-1 monoclonal antibody combined with anti-angiogenic therapy shows anti-tumor ac...

Chao **g, Junyun Wang, Mingyue Zhu, Zhigang Bai… in Cancer Immunology, Immunotherapy (2022)

Article

Alternative approaches to target Myc for cancer treatment

The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc, respectively. Myc protein orchestrates diverse physi...

Chen Wang, Jiawei Zhang, Jie Yin, Yichao Gan… in Signal Transduction and Targeted Therapy (2021)

Article

Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways

The immune system initiates robust immune responses to defend against invading pathogens or tumor cells and protect the body from damage, thus acting as a fortress of the body. However, excessive responses cau...

Jiaxin Liu, Yicheng Cheng, Ming Zheng… in Signal Transduction and Targeted Therapy (2021)

Article

Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy

Insulin-like growth factors (IGFs) play important roles in mammalian growth, development, aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and tumor progression, thus providing...

Hui Hua, Qingbin Kong, Jie Yin, ** Zhang, Yangfu Jiang in Journal of Hematology & Oncology (2020)

Article

NT1014, a novel biguanide, inhibits ovarian cancer growth in vitro and in vivo

NT1014 is a novel biguanide and AMPK activator with a high affinity for the organic cation-specific transporters, OCT1 and OCT3. We sought to determine the anti-tumorigenic effects of NT1014 in human ovarian c...

Lu Zhang, Jianjun Han, Amanda L. Jackson… in Journal of Hematology & Oncology (2016)

Article

Mutations in the D1 domain of von Willebrand factor impair their propeptide-dependent multimerization, intracellular trafficking and secretion

We identified three novel mutations (p.Gly39Arg, p.Lys157Glu, p.Cys379Gly) and one previously known mutation (p.Asp141Asn) in the von Willebrand factor propeptide from three von Willebrand disease patients. Al...

Jie Yin, Zhenni Ma, Jian Su, Jiong-Wei Wang… in Journal of Hematology & Oncology (2015)