18 Result(s)
within
**-Sup Shin
Pharmacy
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Article
Cardioprotective effect of KR-33889, a novel PARP inhibitor, against oxidative stress-induced apoptosis in H9c2 cells and isolated rat hearts
Oxidative stress plays a critical role in cardiac injury during ischemia/reperfusion (I/R). Despite a potent cardioprotective activity of KR-33889, a novel poly (ADP-ribose) polymerase inhibitor, its underlyin...
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Article
Simultaneous Detection of Glabridin, (−)-α-Bisabolol, and Ascorbyl Tetraisopalmitate in Whitening Cosmetic Creams Using HPLC-PAD
A simultaneous analytical method was developed and validated to quantify three lipophilic compounds; namely glabridin (an isoflavonoid isolated from crude licorice), (−)-α-bisabolol (a sesquiterpene alcohol ob...
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Cardioprotective effects of the novel Na+/H+ exchanger-1 inhibitor KR-32560 in a perfused rat heart model of global ischemia and reperfusion: Involvement of the Akt-GSK-3β cell survival pathway and antioxidant enzyme
To investigate the cardioprotective effects and mechanism of action of KR-32560 {[5-(2-methoxy-5-fluorophenyl)furan-2-ylcarbonyl]guanidine}, a newly synthesized NHE-1 inhibitor, we evaluated the effects of KR-...
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Article
KR-31762, a novel KATP channel opener, exerts cardioprotective effects by opening SarcKATP channels in rat models of ischemia/reperfusion-induced heart injury
The cardioprotective effects of KR-31762, a newly synthesized K+ ATP opener, were evaluated in rat models of ischemia/reperfusion (I/R) heart injury. In isolated rat hearts subjected to 30...
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15,16-Dihydrotanshinone I, a major component from Salvia miltiorrhiza Bunge (Dansham), inhibits rabbit platelet aggregation by suppressing intracellular calcium mobilization
Radix Salviae miltiorrhiza (RSM, ‘Dansham’ in Korea, ‘Danshen’ in Chinese), the root of Salviae miltiorrhiza Bunge (Labiate) has been used as Chinese fork medicine for the treatment of cardiovascular diseases ...
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Article
Chromone and chromanone derivatives as strand transfer inhibitors of HIV-1 integrase
HIV-1 integrase catalyzes terminal cleavage at the 3′ end of the proviral DNA, removing a pair of bases and causing strand transfer by joining the 3′ end to 5′-phosphates in the target DNA. Several aryl 1,3-di...
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Article
Spleen tyrosine kinase participates in src-mediated migration and proliferation by PDGF-BB in rat aortic smooth muscle cells
Tyrosine kinases, Src and spleen tyrosine kinase (Syk), play crucial roles in cell responses to platelet-derived growth factor (PDGF) and may have their functional interactions. In this study, we focused on in...
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Article
Cardioprotective effects of bms-180448, a prototype mitokatp channel opener, and the role of salvage kinases, in the rat model of global ischemia and reperfusion heart injury
To investigate the involvement of reperfusion-induced salvage kinases (RISK) as possible signaling molecules for the cardioprotective effects of BMS-180448, a prototype mitochondrial ATP-sensitive K+ (mitoKATP) c...
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Article
Oleanolic acid, a pentacyclic triterpenoid, induces rabbit platelet aggregation through a phospholipase C-calcium dependent signaling pathway
Oleanolic acid (3β-hydroxy-olea-12-en-28-oic), a pentacyclic triterpenoid, exists widely in the plant kingdom and has a wide variety of pharmacological effects such as antitumor, antifungal, insecticidal, hepa...
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Article
Phorbol ester-induced contraction through p38 mitogen-activated protein kinase is diminished in aortas from DOCA-salt hypertensive rats
The role of mitogen-activated protein kinase (MAPK) in the decreased contractile response to phorbol ester in aortic smooth muscle strips from deoxycorticosterone acetate (DOCA)-salt hypertensive rats was exam...
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Article
Antiplatelet activity of [5-(2-methoxy-5-chlorophenyl)furan-2-ylcarbonyl]guanidine (KR-32570), a novel sodium/hydrogen exchanger-1 and its mechanism of action
The antiplatelet effects of a novel guanidine derivative, KR-32570 ([5-(2-methoxy-5-chlorophenyl) furan-2-ylcarbonyl]guanidine), were investigated with an emphasis on the mechanisms underlying its inhibition o...
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Article
BMS-191095, a cardioselective mitochondrial katp opener, inhibits human platelet aggregation by opening mitochondrial katp channels
We evaluated the antiplatelet effects of two classes of ATP-sensitive potassium channel openers (KATP openers) on washed human platelets, and the study’s emphasis was on the role of mitochondrial KATP in platelet...
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Article
Nelumbinis Semen reverses a decrease in 5-HT1A receptor binding induced by chronic mild stress, a depression-like symptom
Depression is associated with a dysfunctional serotonin (5-hydroxytryptamine; 5-HT) system. More recently, several lines of evidence suggest that an important factor in the development of depression may be a d...
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Article
Human, Rat, and Mouse Metabolism of Resveratrol
Purpose. Resveratrol, a phenolic phytoalexin occurring in grapes, wine, peanuts, and cranberries, has been reported to have anticarcinogenic, antioxidative, phytoestrogenic, and cardioprotective activities. Beca...
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Article
HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum
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Article
HIV-1 integrase inhibitory phenylpropanoid glycosides fromClerodendron trichotomum
Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside (6), and isomartynoside (7) were isolated fromClerodendron tric...
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Article
Effects of age on angiotensin II response and antagonistic activity of losartan in rat aorta and liver
The present study was undertaken to investigate the effects of age on angiotensin II (All) response and antagonistic activity of losartan using aortic rings and liver homogenates from rats ranging in age from ...
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In vivo pharmacological evaluation of newly synthesized nonpeptidic AT1 receptor antagonists in rats
This study was conducted to characterize thein vivo pharmacology of KR-30988, KR-30992 and losartan, new AT1 antagonists, given as i.v. cumulative doses, in two animal models of high renin, conscious renal artery...
